Search Results - "Chaguza, Chrispin"
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Metagenomics for surveillance of respiratory pathogens
Published in Nature reviews. Microbiology (01-05-2021)“…This month’s Genome Watch highlights how metagenomics can be used for surveillance and studying infections with respiratory pathogens…”
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Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation
Published in Nature communications (10-07-2020)“…Genomic evolution, transmission and pathogenesis of Streptococcus pneumoniae , an opportunistic human-adapted pathogen, is driven principally by nasopharyngeal…”
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Assessing the global risk of typhoid outbreaks caused by extensively drug resistant Salmonella Typhi
Published in Nature communications (16-10-2023)“…Since its emergence in 2016, extensively drug resistant (XDR) Salmonella enterica serovar Typhi ( S . Typhi) has become the dominant cause of typhoid fever in…”
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Population genomics of Streptococcus mitis in UK and Ireland bloodstream infection and infective endocarditis cases
Published in Nature communications (06-09-2024)“…Streptococcus mitis is a leading cause of infective endocarditis (IE). However, our understanding of the genomic epidemiology and pathogenicity of…”
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Emergence of Double- and Triple-Gene Reassortant G1P[8] Rotaviruses Possessing a DS-1-Like Backbone after Rotavirus Vaccine Introduction in Malawi
Published in Journal of virology (01-02-2018)“…To combat the high burden of rotavirus gastroenteritis, multiple African countries have introduced rotavirus vaccines into their childhood immunization…”
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Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion
Published in Nature communications (21-07-2022)“…Group B Streptococcus (GBS), or Streptococcus agalactiae , is a pathogen that causes preterm births, stillbirths, and acute invasive neonatal disease burden…”
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Author Correction: Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity
Published in Scientific reports (24-03-2022)Get full text
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Estimating pneumococcal carriage dynamics in adults living with HIV in a mature infant pneumococcal conjugate vaccine programme in Malawi, a modelling study
Published in BMC medicine (27-09-2024)“…Adults living with human immunodeficiency virus (ALWHIV) receiving antiretroviral therapy (ART) exhibit higher pneumococcal carriage prevalence than adults…”
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Author Correction: Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity
Published in Scientific reports (17-03-2021)“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Travel surveillance uncovers dengue virus dynamics and introductions in the Caribbean
Published in Nature communications (25-04-2024)“…Dengue is the most prevalent mosquito-borne viral disease in humans, and cases are continuing to rise globally. In particular, islands in the Caribbean have…”
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Genetic markers associated with host status and clonal expansion of Group B Streptococcus in the Netherlands
Published in Frontiers in microbiology (10-07-2024)“…Certain Group B Streptococcus (GBS) genotypes are associated with invasive disease in neonates. We conducted a comparative genomic analysis of GBS isolates…”
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Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity
Published in Scientific reports (14-10-2020)“…Streptococcus pneumoniae is a devastating global pathogen. Prevalent in sub-Saharan Africa, pneumococcal serotype 1 is atypical in that it is rarely found as a…”
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Daily Rapid Antigen Exit Testing to Tailor University COVID-19 Isolation Policy
Published in Emerging infectious diseases (01-12-2022)“…We evaluated daily rapid antigen test (RAT) data from 323 COVID-19-positive university students in Connecticut, USA, during an Omicron-dominant period. Day 5…”
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Evaluation of Dried Blood and Cerebrospinal Fluid Filter Paper Spots for Storing and Transporting Clinical Material for the Molecular Diagnosis of Invasive Meningococcal Disease
Published in International journal of molecular sciences (06-10-2022)“…To improve the storage and transport of clinical specimens for the diagnosis of Neisseria meningitidis (Nm) infections in resource-limited settings, we have…”
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DengueSeq: a pan-serotype whole genome amplicon sequencing protocol for dengue virus
Published in BMC genomics (01-05-2024)“…The increasing burden of dengue virus on public health due to more explosive and frequent outbreaks highlights the need for improved surveillance and control…”
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Whole genomic comparative analysis of Streptococcus pneumoniae serotype 1 isolates causing invasive and non-invasive infections among children under 5 years in Casablanca, Morocco
Published in BMC genomics (07-01-2021)“…Streptococcus pneumoniae serotype 1 remains a leading cause of invasive pneumococcal diseases, even in countries with PCV-10/PCV-13 vaccine implementation. The…”
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Recombination in Streptococcus pneumoniae Lineages Increase with Carriage Duration and Size of the Polysaccharide Capsule
Published in mBio (27-09-2016)“…Streptococcus pneumoniae causes a high burden of invasive pneumococcal disease (IPD) globally, especially in children from resource-poor settings. Like many…”
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Mechanisms and impact of genetic recombination in the evolution of Streptococcus pneumoniae
Published in Computational and structural biotechnology journal (01-01-2015)“…Streptococcus pneumoniae (the pneumococcus) is a highly recombinogenic bacterium responsible for a high burden of human disease globally. Genetic…”
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Lower Density and Shorter Duration of Nasopharyngeal Carriage by Pneumococcal Serotype 1 (ST217) May Explain Its Increased Invasiveness over Other Serotypes
Published in mBio (08-12-2020)“…is a frequent colonizer of the human nasopharynx and a major cause of life-threating invasive infections such as pneumonia, meningitis and sepsis. Over 1…”
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The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1
Published in Vaccine (07-02-2017)“…Abstract Serotype 1 is one of the most common causes of pneumococcal disease worldwide. Pneumococcal protein vaccines are currently being developed as an…”
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