Search Results - "Chagnon, Frederic"

Apelin-13 administration allows for norepinephrine sparing in a rat model of cecal ligation and puncture-induced septic shock by Salvail, William, Salvail, Dany, Chagnon, Frédéric, Lesur, Olivier

“…Background Infusion of exogenous catecholamines (i.e., norepinephrine [NE] and dobutamine) is a recommended treatment for septic shock with myocardial…”
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ELABELA Improves Cardio-Renal Outcome in Fatal Experimental Septic Shock by Coquerel, David, Chagnon, Frédéric, Sainsily, Xavier, Dumont, Lauralyne, Murza, Alexandre, Côté, Jérôme, Dumaine, Robert, Sarret, Philippe, Marsault, Éric, Salvail, Dany, Auger-Messier, Mannix, Lesur, Olivier

“…OBJECTIVES:Apelin-13 was recently proposed as an alternative to the recommended β-adrenergic drugs for supporting endotoxin-induced myocardial dysfunction…”
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Gαi-biased apelin analog protects against isoproterenol-induced myocardial dysfunction in rats by Coquerel, David, Delile, Eugénie, Dumont, Lauralyne, Chagnon, Frédéric, Murza, Alexandre, Sainsily, Xavier, Salvail, Dany, Sarret, Philippe, Marsault, Eric, Auger-Messier, Mannix, Lesur, Olivier

“…Apelin receptor (APJ) activation by apelin-13 (APLN-13) engages both Gαi proteins and β-arrestins, stimulating distinct intracellular pathways and triggering…”
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Process-Specific Blood Biomarkers and Outcomes in COVID-19 Versus Non-COVID-19 ARDS (APEL-COVID Study): A Prospective, Observational Cohort Study by Lesur, Olivier, Segal, Eric David, Rego, Kevin, Mercat, Alain, Asfar, Pierre, Chagnon, Frédéric

“…Severe acute respiratory syndrome (SARS) and acute respiratory distress syndrome (ARDS) are often considered separate clinico-radiological entities. Whether…”
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Hemodynamic impacts of apelin-13 in a neonatal lamb model of septic peritonitis by Simard, Émile, Morin, Christophe, Coquerel, David, Chagnon, Frédéric, Nadeau, Charlène, Samson, Nathalie, Praud, Jean-Paul, Lesur, Olivier, Fortin-Pellerin, Étienne

“…Background Apelins are potential candidate therapeutic molecules for hemodynamic support. The objective of this study was to assess the hemodynamic impacts of…”
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D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF) by Merk, Melanie, Zierow, Swen, Leng, Lin, Das, Rituparna, Du, Xin, Schulte, Wibke, Fan, Juan, Lue, Hongqi, Chen, Yibang, Xiong, Huabao, Chagnon, Frederic, Bernhagen, Jürgen, Lolis, Elias, Mor, Gil, Lesur, Olivier, Bucala, Richard

“…Macrophage migration inhibitory factor (MIF) is a pivotal regulator of the immune response. Neutralization or genetic deletion of MIF does not completely…”
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In Vivo Endomicroscopy of Lung Injury and Repair in ARDS: Potential Added Value to Current Imaging by Lesur, Olivier, Chagnon, Frédéric, Lebel, Réjean, Lepage, Martin

“…Standard clinical imaging of the acute respiratory distress syndrome (ARDS) lung lacks resolution and offers limited possibilities in the exploration of the…”
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Music and biological stress dampening in mechanically-ventilated patients at the intensive care unit ward—a prospective interventional randomized crossover trial by Beaulieu-Boire, Genevieve, MD, Bourque, Solange, MD, Chagnon, Frederic, MSc, Chouinard, Lucie, BsC, Gallo-Payet, Nicole, PhD, Lesur, Olivier, MD PhD

“…Abstract Purpose To evaluate the impact of slow-tempo music listening periods in mechanically ventilated intensive care unit patients. Methods A randomized…”
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Smart imaging of acute lung injury: exploration of myeloperoxidase activity using in vivo endoscopic confocal fluorescence microscopy by Chagnon, Frédéric, Bourgouin, Alexandra, Lebel, Réjean, Bonin, Marc-André, Marsault, Eric, Lepage, Martin, Lesur, Olivier

“…The pathophysiology of acute lung injury (ALI) is well characterized, but its real-time assessment at bedside remains a challenge. When patients do not improve…”
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Impact of deforestation in the Amazon basin on cloud climatology by Wang, Jingfeng, Chagnon, Frédéric J.F, Williams, Earle R, Betts, Alan K, Renno, Nilton O, Machado, Luiz A.T, Bisht, Gautam, Knox, Ryan, Bras, Rafael L

“…Shallow clouds are prone to appear over deforested surfaces whereas deep clouds, much less frequent than shallow clouds, favor forested surfaces. Simultaneous…”
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Improving the evaluation of cardiac function in rats at 7T with denoising filters: a comparison study by Tricot, Benoit, Descoteaux, Maxime, Dumont, Matthieu, Chagnon, Frederic, Tremblay, Luc, Carpentier, André, Lesur, Olivier, Lepage, Martin, Lalande, Alain

“…We investigate the use of different denoising filters on low signal-to-noise ratio cardiac images of the rat heart acquired with a birdcage volume coil at 7T…”
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Endotoxin-induced heart dysfunction in rats: Assessment of myocardial perfusion and permeability and the role of fluid resuscitation by Chagnon, Frederic, Bentourkia, M’hamed, Lecomte, Roger, Lessard, Michel, Lesur, Olivier

“…OBJECTIVE:The pathophysiology of sepsis-induced myocardial dysfunction is still controversial. Whether microcirculatory hypoperfusion together with capillary…”
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Apelin-13 in septic shock: effective in supporting hemodynamics in sheep but compromised by enzymatic breakdown in patients by Coquerel, David, Lamoureux, Julie, Chagnon, Frédéric, Trân, Kien, Sage, Michael, Fortin-Pellerin, Etienne, Delile, Eugénie, Sainsily, Xavier, Fournier, Justin, Dumont, Audrey-Ann, Auger-Messier, Mannix, Sarret, Philippe, Marsault, Eric, Praud, Jean-Paul, Fülöp, Tamàs, Lesur, Olivier

“…Sepsis is a prevalent life-threatening condition related to a systemic infection, and with unresolved issues including refractory septic shock and organ…”
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Modulation of aquaporin-2/vasopressin2 receptor kidney expression and tubular injury after endotoxin (lipopolysaccharide) challenge by Chagnon, Frederic, Vaidya, Vishal S, Plante, Gerard E, Bonventre, Joseph V, Bernard, Alfred, Guindi, Chantal, Lesur, Olivier

“…OBJECTIVE:Sepsis-induced organ dysfunctions remain prevalent and account for >50% of intensive care unit admissions for acute renal failure with a mortality…”
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Donald R. F. Harleman: A Life of Excellence and an Excellent Life by Bras, Rafael L, Chagnon, Frédéric, Adams, Eric E, Atkinson, Joseph, Madsen, Ole, Murcott, Susan, Shamir, Uri, Shanahan, Peter, Thatcher, Lew

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Apelin Compared With Dobutamine Exerts Cardioprotection and Extends Survival in a Rat Model of Endotoxin-Induced Myocardial Dysfunction by Chagnon, Frederic, Coquerel, David, Salvail, Dany, Marsault, Eric, Dumaine, Robert, Auger-Messier, Mannix, Sarret, Philippe, Lesur, Olivier

“…OBJECTIVE:Dobutamine is the currently recommended β-adrenergic inotropic drug for supporting sepsis-induced myocardial dysfunction when cardiac output index…”
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Resuscitation fluids and endotoxin-induced myocardial dysfunction: is selection a load-independent differential issue? by Hogue, Bruno, Chagnon, Frederic, Lesur, Olivier

“…Along with redistributive shock, myocardial dysfunction is now recognized as highly prevalent in early severe sepsis. Indeed, aside from their distinct loading…”
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Tracking of Mesenchymal Stem Cells with Fluorescence Endomicroscopy Imaging in Radiotherapy-Induced Lung Injury by Perez, Jessica R., Ybarra, Norma, Chagnon, Frederic, Serban, Monica, Lee, Sangkyu, Seuntjens, Jan, Lesur, Olivier, El Naqa, Issam

“…Mesenchymal stem cells (MSCs) have potential for reducing inflammation and promoting organ repair. However, limitations in available techniques to track them…”
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Image-Guided Fluorescence Endomicroscopy: From Macro- to Micro-Imaging of Radiation-Induced Pulmonary Fibrosis by Perez, Jessica R., Ybarra, Norma, Chagnon, Frederic, Serban, Monica, Pare, Gabriel, Lesur, Olivier, Seuntjens, Jan, Naqa, Issam El

“…Radiation-induced pulmonary fibrosis (RIPF) is a debilitating side effect of radiation therapy (RT) of several cancers including lung and breast cancers…”
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Proven infection-related sepsis induces a differential stress response early after ICU admission by Lesur, Olivier, Roussy, Jean-Francois, Chagnon, Frederic, Gallo-Payet, Nicole, Dumaine, Robert, Sarret, Philippe, Chraibi, Ahmed, Chouinard, Lucie, Hogue, Bruno

“…Neuropeptides arginine-vasopressin (AVP), apelin (APL), and stromal-derived factor-1α (SDF-1α) are involved in the dysfunction of the corticotropic axis…”
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