Abnormal vascular and neural retinal morphology in congenital lifetime isolated growth hormone deficiency

Abstract Objective Experimental models demonstrate an important role of GH in retinal development. However, the interactions between GH and the neuro-vascularization of the human retina are still not clear. A model of untreated congenital isolated GH deficiency (IGHD) may clarify the action of GH on...

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Published in:	Growth hormone & IGF research Vol. 30-31; pp. 11 - 15
Main Authors:	Pereira-Gurgel, Virginia M, Faro, Augusto C.N, Salvatori, Roberto, Chagas, Thiago A, Carvalho-Junior, José F, Oliveira, Carla R.P, Costa, Ursula M.M, Melo, Gustavo B, Hellström, Ann, Aguiar-Oliveira, Manuel H
Format:	Journal Article
Language:	English
Published:	Scotland Elsevier Ltd 01-10-2016
Subjects:	Adult Advanced Basic Science Aged Case-Control Studies Cross-Sectional Studies Dwarfism, Pituitary - congenital Dwarfism, Pituitary - genetics Dwarfism, Pituitary - pathology Endocrinology & Metabolism Female Humans IGF-I Intraocular Pressure Isolated GH deficiency Macula Lutea - pathology Male Middle Aged Oftalmologi Ophthalmology Receptors, Neuropeptide - genetics Receptors, Pituitary Hormone-Regulating Hormone - genetics Retina Retinal Neurons - pathology Retinal Vessels - pathology Tomography, Optical Coherence Isolated GH deficiency GH Retina IGF-I
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Summary:	Abstract Objective Experimental models demonstrate an important role of GH in retinal development. However, the interactions between GH and the neuro-vascularization of the human retina are still not clear. A model of untreated congenital isolated GH deficiency (IGHD) may clarify the action of GH on the retina. The purpose of this work was to assess the retinal neuro-vascularization in untreated congenital IGHD (cIGHD). Design In a cross sectional study, we performed an endocrine and ophthalmological assessment of 25 adult cIGHD subjects, homozygous for a null mutation (c.57 + 1G > A) in the GHRH receptor gene and 28 matched controls. Intraocular pressure measurement, retinography (to assess the number of retinal vascular branching points and the optic disc and cup size), and optical coherence tomography (to assess the thickness of macula) were performed. Results cIGHD subjects presented a more significant reduction of vascular branching points in comparison to controls (91% vs. 53% [ p = 0.049]). The percentage of moderate reduction was higher in cIGHD than in controls ( p = 0.01). The percentage of individuals with increased optic disc was higher in cIGHD subjects in comparison to controls (92.9% vs. 57.1%). The same occurred for cup size (92.9% vs. 66.7%), p < 0.0001 in both cases. There was no difference in macula thickness. Conclusions Most cIGHD individuals present moderate reduction of vascular branching points, increase of optic disc and cup size, but have similar thickness of the macula.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1096-6374 1532-2238 1532-2238
DOI:	10.1016/j.ghir.2016.07.001