Search Results - "Chaganty, Bharat K.R."

Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab by Luo, Jingtao, Hong, Yun, Lu, Yang, Qiu, Songbo, Chaganty, Bharat K.R, Zhang, Lun, Wang, Xudong, Li, Qiang, Fan, Zhen

“…Abstract Cetuximab inhibits HIF-1-regulated glycolysis in cancer cells, thereby reversing the Warburg effect and leading to inhibition of cancer cell…”
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Tumor Necrosis Factor Alpha Production from CD8⁺ T Cells Mediates Oviduct Pathological Sequelae following Primary Genital Chlamydia muridarum Infection by Murthy, Ashlesh K, Li, Weidang, Chaganty, Bharat K.R, Kamalakaran, Sangamithra, Guentzel, M. Neal, Seshu, J, Forsthuber, Thomas G, Zhong, Guangming, Arulanandam, Bernard P

“…The immunopathogenesis of Chlamydia trachomatis-induced oviduct pathological sequelae is not well understood. Mice genetically deficient in perforin…”
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Heat denatured enzymatically inactive recombinant chlamydial protease-like activity factor induces robust protective immunity against genital chlamydial challenge by Chaganty, Bharat K.R, Murthy, Ashlesh K, Evani, Shankar J, Li, Weidang, Guentzel, M. Neal, Chambers, James P, Zhong, Guangming, Arulanandam, Bernard P

“…Abstract We have shown previously that vaccination with recombinant chlamydial protease-like activity factor (rCPAF) plus interleukin-12 as an adjuvant induces…”
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Trastuzumab upregulates PD-L1 as a potential mechanism of trastuzumab resistance through engagement of immune effector cells and stimulation of IFNγ secretion by Chaganty, Bharat K.R., Qiu, Songbo, Gest, Anneliese, Lu, Yang, Ivan, Cristina, Calin, George A., Weiner, Louis M., Fan, Zhen

“…Here, we report that treatment of syngeneic mouse tumors transduced to overexpress human epidermal growth factor receptor-2 (HER2) with the anti-human HER2…”
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limited role for antibody in protective immunity induced by rCPAF and CpG vaccination against primary genital Chlamydia muridarum challenge by Murthy, Ashlesh K, Chaganty, Bharat K.R, Li, Weidang, Guentzel, M. Neal, Chambers, James P, Seshu, J, Zhong, Guangming, Arulanandam, Bernard P

“…Mice deficient in B cells (μmT mice) were used to evaluate the role of antibody in enhanced chlamydial clearance and reduction of pathology afforded by…”
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Redirecting host preexisting influenza A virus immunity for cancer immunotherapy by Chaganty, Bharat K. R., Qiu, Songbo, Lu, Yang, Lopez-Berestein, Gabriel, Ozpolat, Bulent, Fan, Zhen

“…We tested the concept that host preexisting influenza A virus immunity can be redirected to inhibit tumor growth and metastasis through systemic administration…”
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Trastuzumab upregulates expression of HLA-ABC and T cell costimulatory molecules through engagement of natural killer cells and stimulation of IFNγ secretion by Chaganty, Bharat K. R., Lu, Yang, Qiu, Songbo, Somanchi, Srinivas S., Lee, Dean A., Fan, Zhen

“…It is increasingly recognized that trastuzumab, an antibody approved for treating human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer,…”
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Intranasal vaccination with Chlamydia pneumoniae induces cross-species immunity against genital Chlamydia muridarum challenge in mice by Manam, Srikanth, Chaganty, Bharat K R, Evani, Shankar Jaikishan, Zafiratos, Mark T, Ramasubramanian, Anand K, Arulanandam, Bernard P, Murthy, Ashlesh K

“…Chlamydia trachomatis is the most common bacterial sexually transmitted disease in the world and specifically in the United States, with the highest incidence…”
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Neonatal chlamydial pneumonia induces altered respiratory structure and function lasting into adult life by Jupelli, Madhulika, Murthy, Ashlesh K, Chaganty, Bharat KR, Guentzel, M Neal, Selby, Dale M, Vasquez, Margarita M, Mustafa, Shamimunisa B, Henson, Barbara M, Seidner, Steven R, Zhong, Guangming, Arulanandam, Bernard P

“…Respiratory dysfunction in adults has been correlated with neonatal Chlamydia trachomatis pneumonia in several studies, but a causal association has not been…”
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Mannose-containing oligosaccharides of non-specific human secretory immunoglobulin A mediate inhibition of Vibrio cholerae biofilm formation by Murthy, Ashlesh K, Chaganty, Bharat K R, Troutman, Ty, Guentzel, M Neal, Yu, Jieh-Juen, Ali, Syed Khalid, Lauriano, Crystal M, Chambers, James P, Klose, Karl E, Arulanandam, Bernard P

“…The role of antigen-specific secretory IgA (SIgA) has been studied extensively, whereas there is a limited body of evidence regarding the contribution of…”
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Vaginal chlamydial clearance following primary or secondary infection in mice occurs independently of TNF-α by Kamalakaran, Sangamithra, Chaganty, Bharat K R, Gupta, Rishein, Guentzel, M Neal, Chambers, James P, Murthy, Ashlesh K, Arulanandam, Bernard P

“…The role of TNF-α in chlamydial clearance is uncertain. Antibody-mediated depletion of TNF-α in mice and guinea pigs has been shown not to significantly affect…”
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