Search Results - "Chaganty, Bharat"

Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab by Luo, Jingtao, Hong, Yun, Lu, Yang, Qiu, Songbo, Chaganty, Bharat K.R, Zhang, Lun, Wang, Xudong, Li, Qiang, Fan, Zhen

“…Abstract Cetuximab inhibits HIF-1-regulated glycolysis in cancer cells, thereby reversing the Warburg effect and leading to inhibition of cancer cell…”
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Trastuzumab upregulates PD-L1 as a potential mechanism of trastuzumab resistance through engagement of immune effector cells and stimulation of IFNγ secretion by Chaganty, Bharat K.R., Qiu, Songbo, Gest, Anneliese, Lu, Yang, Ivan, Cristina, Calin, George A., Weiner, Louis M., Fan, Zhen

“…Here, we report that treatment of syngeneic mouse tumors transduced to overexpress human epidermal growth factor receptor-2 (HER2) with the anti-human HER2…”
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Tumor Necrosis Factor Alpha Production from CD8⁺ T Cells Mediates Oviduct Pathological Sequelae following Primary Genital Chlamydia muridarum Infection by Murthy, Ashlesh K, Li, Weidang, Chaganty, Bharat K.R, Kamalakaran, Sangamithra, Guentzel, M. Neal, Seshu, J, Forsthuber, Thomas G, Zhong, Guangming, Arulanandam, Bernard P

“…The immunopathogenesis of Chlamydia trachomatis-induced oviduct pathological sequelae is not well understood. Mice genetically deficient in perforin…”
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Redirecting host preexisting influenza A virus immunity for cancer immunotherapy by Chaganty, Bharat K. R., Qiu, Songbo, Lu, Yang, Lopez-Berestein, Gabriel, Ozpolat, Bulent, Fan, Zhen

“…We tested the concept that host preexisting influenza A virus immunity can be redirected to inhibit tumor growth and metastasis through systemic administration…”
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Mannose-containing oligosaccharides of non-specific human secretory immunoglobulin A mediate inhibition of Vibrio cholerae biofilm formation by Murthy, Ashlesh K, Chaganty, Bharat K R, Troutman, Ty, Guentzel, M Neal, Yu, Jieh-Juen, Ali, Syed Khalid, Lauriano, Crystal M, Chambers, James P, Klose, Karl E, Arulanandam, Bernard P

“…The role of antigen-specific secretory IgA (SIgA) has been studied extensively, whereas there is a limited body of evidence regarding the contribution of…”
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Trastuzumab upregulates expression of HLA-ABC and T cell costimulatory molecules through engagement of natural killer cells and stimulation of IFNγ secretion by Chaganty, Bharat K. R., Lu, Yang, Qiu, Songbo, Somanchi, Srinivas S., Lee, Dean A., Fan, Zhen

“…It is increasingly recognized that trastuzumab, an antibody approved for treating human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer,…”
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Heat denatured enzymatically inactive recombinant chlamydial protease-like activity factor induces robust protective immunity against genital chlamydial challenge by Chaganty, Bharat K.R, Murthy, Ashlesh K, Evani, Shankar J, Li, Weidang, Guentzel, M. Neal, Chambers, James P, Zhong, Guangming, Arulanandam, Bernard P

“…Abstract We have shown previously that vaccination with recombinant chlamydial protease-like activity factor (rCPAF) plus interleukin-12 as an adjuvant induces…”
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Intranasal vaccination with Chlamydia pneumoniae induces cross-species immunity against genital Chlamydia muridarum challenge in mice by Manam, Srikanth, Chaganty, Bharat K R, Evani, Shankar Jaikishan, Zafiratos, Mark T, Ramasubramanian, Anand K, Arulanandam, Bernard P, Murthy, Ashlesh K

“…Chlamydia trachomatis is the most common bacterial sexually transmitted disease in the world and specifically in the United States, with the highest incidence…”
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VIS832, a novel CD138-targeting monoclonal antibody, potently induces killing of human multiple myeloma and further synergizes with IMiDs or bortezomib in vitro and in vivo by Yu, Tengteng, Chaganty, Bharat, Lin, Liang, Xing, Lijie, Ramakrishnan, Boopathy, Wen, Kenneth, Hsieh, Phillip A., Wollacott, Andrew, Viswanathan, Karthik, Adari, Hedy, Cho, Shih-Feng, Li, Yuyin, Chen, Hailin, Yang, Wenjuan, Xu, Yan, An, Gang, Qiu, Lugui, Munshi, Nikhil, Babcock, Gregory, Shriver, Zachary, Myette, James R., Anderson, Kenneth C., Tai, Yu-Tzu

“…Therapeutically targeting CD138, a define multiple myeloma (MM) antigen, is not yet approved for patients. We here developed and determined the preclinical…”
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Neonatal chlamydial pneumonia induces altered respiratory structure and function lasting into adult life by Jupelli, Madhulika, Murthy, Ashlesh K, Chaganty, Bharat KR, Guentzel, M Neal, Selby, Dale M, Vasquez, Margarita M, Mustafa, Shamimunisa B, Henson, Barbara M, Seidner, Steven R, Zhong, Guangming, Arulanandam, Bernard P

“…Respiratory dysfunction in adults has been correlated with neonatal Chlamydia trachomatis pneumonia in several studies, but a causal association has not been…”
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Vaginal chlamydial clearance following primary or secondary infection in mice occurs independently of TNF-α by Kamalakaran, Sangamithra, Chaganty, Bharat K R, Gupta, Rishein, Guentzel, M Neal, Chambers, James P, Murthy, Ashlesh K, Arulanandam, Bernard P

“…The role of TNF-α in chlamydial clearance is uncertain. Antibody-mediated depletion of TNF-α in mice and guinea pigs has been shown not to significantly affect…”
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limited role for antibody in protective immunity induced by rCPAF and CpG vaccination against primary genital Chlamydia muridarum challenge by Murthy, Ashlesh K, Chaganty, Bharat K.R, Li, Weidang, Guentzel, M. Neal, Chambers, James P, Seshu, J, Zhong, Guangming, Arulanandam, Bernard P

“…Mice deficient in B cells (μmT mice) were used to evaluate the role of antibody in enhanced chlamydial clearance and reduction of pathology afforded by…”
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A Novel CD138-Targeting Monoclonal Antibody Induces Potent Myeloma Killing and Further Synergizes with IMiDs or Bortezomib in in Vitro and In Vivo Preclinical Models of Human Multiple Myeloma by Yu, Tengteng, Chaganty, Bharat, Lin, Liang, Xing, Lijie, Ramakrishnan, Boopathy, Wen, Kenneth, Hsieh, Phillip A, Wollacott, Andrew, Viswanathan, Karthik, Adari, Hedy, Cho, Shih-Feng, Li, Yuyin, Yang, Wenjuan, Chen, Hailin, Xu, Yan, An, Gang, Qiu, Lugui, Munshi, Nikhil C., Babcock, Gregory, Shriver, Zach, Myette, James, Anderson, Kenneth, Tai, Yu-Tzu

“…Immunotherapeutically targeting CD138 has not been successfully translated into substantial clinical benefit in multiple myeloma (MM) patients. We here…”
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An Immune Based, Anti-CD138 Targeting Antibody for the Treatment of Multiple Myeloma by Yu, Tengteng, Xing, Lijie, Lin, Liang, Liu, Jiye, Wen, Kenneth, Cho, Shih-Feng, Hsieh, Phillip, Myette, James, Chaganty, Bharat, Adari, Hedy, Tissire, Hamid, Deotale, Ketan, Shriver, Zach, Munshi, Nikhil, Tai, Yu-Tzu, Anderson, Kenneth

“…CD138 (Syndecan-1), a member of integral membrane family of heparan sulfate proteoglycans (HSPGS), is highly expressed on differentiated plasma cells (PC) and…”
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Intranasal Vaccination with Chlamydia pneumoniae Induces Cross-Species Immunity against Genital Chlamydia muridarum Challenge in Mice. e64917 by Manam, Srikanth, Chaganty, Bharat KR, Evani, Shankar Jaikishan, Zafiratos, Mark T, Ramasubramanian, Anand K, Arulanandam, Bernard P, Murthy, Ashlesh K

“…Chlamydia trachomatis is the most common bacterial sexually transmitted disease in the world and specifically in the United States, with the highest incidence…”
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Comparison of enzymatically active and denatured recombinant chlamydial protease like activity factor as protective immunogens against genital chlamydial challenge by Chaganty, Bharat Kumar Reddy

“…We have shown previously the efficacy of intranasal vaccination with recombinant chlamydial protease-like activity factor (rCPAF) plus interleukin-12 in the…”
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A limited role for antibody in protective immunity induced by rCPAF and CpG vaccination against primary genital Chlamydia muridarum challenge: Chlamydia by MURTHY, Ashlesh K, CHAGANTY, Bharat K. R, WEIDANG LI, GUENTZEL, M. Neal, CHAMBERS, James P, SESHU, J, GUANGMING ZHONG, ARULANANDAM, Bernard P

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