Search Results - "Chagaleti, Bharath Kumar"

Imidazooxazine moiety as polyketide synthase 13 inhibitors targeting tuberculosis by Shanthakumar, B., Gopinath, P., Chagaleti, Bharath Kumar, Saravanan, Venkatesan, Palaniappan, Senthil Kumar, Musaed Almutairi, Saeedah, Hussein, Dina S., Eisa, Yasmine Hamdy, Kathiravan, M.K., Arockiaraj, Jesu

“…Recently, imidazooxazineshave attracted more attention due to their therapeutic potential against tuberculosis (TB). The present study aimed to identify and…”
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Exploring cyclin-dependent kinase inhibitors: a comprehensive study in search of CDK-6 inhibitors using a pharmacophore modelling and dynamics approach by Chagaleti, Bharath Kumar, Saravanan, Venkatesan, Vellapandian, Chitra, Kathiravan, Muthu K

“…Cancer prevalence and resistance issues in cancer treatment are a significant public health concern globally. Among the existing strategies in cancer therapy,…”
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Ligand based pharmacophore modelling and integrated computational approaches in the quest for small molecule inhibitors against hCA IX by Saravanan, Venkatesan, Chagaleti, Bharath Kumar, Packiapalavesam, Shakthi Devi, Kathiravan, Muthukumaradoss

“…Carbonic anhydrase IX is an important biomarker to fight hypoxic tumours in both initial and metastatic stages of many forms of cancer. Overexpression of hCA…”
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Exploring the cyclization of thiosemicarbazone to 1,3,4-thiadiazole: Synthesis, characterization and in-silico study by Mukhrish, Yousef E., Al-Humaidi, Jehan Y., Chagaleti, Bharath Kumar, Albedair, Lamia A., Gomha, Sobhi M., Saravanan, Venkatesan, Kathiravan, MK, Oubella, Ali

“…•A series of isophorone-1,3,4-thiadiazoles 8a-c were synthesized.•Synthetic products are characterized by NMR and HRMS.•Molecular docking and dynamic…”
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1,5- diaryl pyrazole-loaded chitosan nanoparticles as COX-2 inhibitors, mitigate neoplastic growth by regulating NF-κB pathway in-vivo zebrafish model by Murugan, Raghul, Selvam, Madesh, Haridevamuthu, B., Ashok, Kumar, Chagaleti, Bharath Kumar, Priya, D., Rajagopal, Rajakrishnan, Alfarhan, Ahmed, Kumaradoss, Kathiravan Muthu, Arockiaraj, Jesu

“…Non-steroidal anti-inflammatory drugs (NSAIDs) have been researched for their capacity to reduce cancer incidence, primarily due to their COX-2 inhibition…”
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Thymol-1,2,3-triazole derivatives: Network pharmacology, molecular simulations and synthesis targeting breast cancer by Laamari, Yassine, Bimoussa, Abdoullah, Chagaleti, Bharath Kumar, Saravanan, Venkatesan, Alotaibi, Saad H., Alotaibi, Fawziah M., MK, Kathiravan, Oubella, Ali, Itto, Moulay Youssef Ait, Auhmani, Aziz

“…•A series of 1,2,3-triazole derivatives tethered to p-methoxythymol, a natural product was synthesized and further elucidated by detailed analysis of their…”
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Multitargeted molecular docking and dynamics simulation of thymol-based chalcones against cancer protein markers: Synthesis, characterization, and computational study by Laamari, Yassine, Bimoussa, Abdoullah, Mourad, Fawzi, Chagaleti, Bharath Kumar, Saravanan, Venkatesan, Alossaimi, Manal A., Riadi, Yassine, MK, Kathiravan, Oubella, Ali, Itto, Moulay Youssef Ait, Auhmani, Aziz

“…•Novel thymol-chalcone–(4a-f) was synthesized.•The synthesized compounds were further characterized by HRMS, 1H and 13C NMR spectral data.•Molecular docking…”
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A novel brominated chalcone derivative as a promising multi-target inhibitor against multidrug-resistant Listeria monocytogenes by Haridevamuthu, B., Nayak, S.P. Ramya Ranjan, Madesh, S., Dhivya, L.S., Chagaleti, Bharath Kumar, Pasupuleti, Mukesh, Rajakrishnan, R., Alfarhan, Ahmed, Muthu Kumaradoss, Kathiravan, Arockiaraj, Jesu

“…Foodborne pathogens continue to challenge public health due to their ability to cause severe illness and their increasing resistance to current antimicrobial…”
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Discovery and development of COVID‐19 vaccine from laboratory to clinic by Saravanan, Venkatesan, Chagaleti, Bharath Kumar, Narayanan, Pavithra Lakshmi, Anandan, Vijay Babu, Manoharan, Haritha, Anjana, G.V., Peraman, Ramalingam, Namasivayam, S. Karthik Raja, Kavisri, M., Arockiaraj, Jesu, Muthu Kumaradoss, Kathiravan, Moovendhan, Meivelu

“…The world has recently experienced one of the biggest and most severe public health disasters with severe acute respiratory syndrome coronavirus (SARS‐CoV‐2)…”
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Targeting cyclin-dependent kinase 2 CDK2: Insights from molecular docking and dynamics simulation – A systematic computational approach to discover novel cancer therapeutics by Chagaleti, Bharath Kumar, B., Shantha Kumar, G.V., Anjana, Rajagopal, Rajakrishnan, Alfarhan, Ahmed, Arockiaraj, Jesu, Muthu Kumaradoss, Kathiravan, Karthick Raja Namasivayam, S.

“…Global public health is confronted with significant challenges due to the prevalence of cancer and the emergence of treatment resistance. This work focuses on…”
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An overview of mechanism and chemical inhibitors of shikimate kinase by Chagaleti, Bharath Kumar, Reddy, M B Rahul, Saravanan, Venkatesan, B, Shanthakumar, D, Priya, Senthil Kumar, P, Kathiravan, M K

“…Tuberculosis is a highly infectious disease other than HIV/AIDS and it is one of the top ten causes of death worldwide. Resistance development in the bacteria…”
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