Search Results - "Chafiq, Omar Moukha"

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    Discovery of Novel Delta Opioid Receptor (DOR) Inverse Agonist and Irreversible (Non-Competitive) Antagonists by Tanguturi, Parthasaradhireddy, Pathak, Vibha, Zhang, Sixue, Moukha-Chafiq, Omar, Augelli-Szafran, Corinne E, Streicher, John M

    Published in Molecules (Basel, Switzerland) (05-11-2021)
    “…The delta opioid receptor (DOR) is a crucial receptor system that regulates pain, mood, anxiety, and similar mental states. DOR agonists, such as SNC80, and…”
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    Journal Article
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    Structure–activity relationship for adenosine kinase from Mycobacterium tuberculosis by Long, Mary C., Shaddix, Sue C., Moukha-Chafiq, Omar, Maddry, Joseph A., Nagy, Lisa, Parker, William B.

    Published in Biochemical pharmacology (01-04-2008)
    “…Adenosine kinase (Ado kinase) from Mycobacterium tuberculosis is structurally and biochemically unique from other known Ado kinases. This purine salvage enzyme…”
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    The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition by Kelly, Kaela, Wang, Shijie, Boddu, Ravindra, Liu, Zhiyong, Moukha-Chafiq, Omar, Augelli-Szafran, Corinne, West, Andrew B.

    Published in Experimental neurology (01-11-2018)
    “…The G2019S mutation in LRRK2 is one of the most common known genetic causes of neurodegeneration and Parkinson disease (PD). LRRK2 mutations are thought to…”
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    Discovery of Novel Delta Opioid Receptor Antagonists by Tanguturi, Parthasaradhireddy, Pathak, Vibha, Zhang, Sixue, Moukha-Chafiq, Omar, Augelli-Szafran, Corinne E, Streicher, John M

    Published in Molecules (Basel, Switzerland) (01-11-2021)
    “…The delta opioid receptor (DOR) is a crucial receptor system that regulates pain, mood, anxiety, and similar mental states. DOR agonists, such as SNC80, and…”
    Get full text
    Journal Article
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    The D3 receptor antagonist SR 21502 reduces cue-induced reinstatement of methamphetamine-seeking in rats by Ranaldi, Robert, Timken, Patrick, Parasram, Daleya, Ali, Tasmia, Zhang, Sixue, Moukha-Chafiq, Omar, Augelli-Szafran, Corinne, Streicher, John M.

    Published in Neuroscience letters (29-05-2023)
    “…•Dopamine D3 receptors play an important role in methamphetamine seeking.•SR 21502 blocks cue-induced reinstatement of methamphetamine seeking in rats.•SR…”
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    Journal Article
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    Inhibition of the SET/MLL Histone Methyltransferase Complex as a Novel Epigenetic Targeted Therapy in Mixed Lineage Leukemia by Widden, Hayley, MoukhaChafiq, Omar, Whitaker, Robert, Vadukoot, Anish, Augello‐Szafran, Corinne, Boohaker, Rebecca, Bostwick, Robert, Suto, Mark, Placzek, William

    Published in The FASEB journal (01-05-2021)
    “…Aggressive acute leukemias in children, adolescents, and adults arise due to a chromosomal translocation and subsequent fusion that occurs at chromosome 11q23…”
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    SRI 22136, A Novel Delta Opioid Receptor (DOR) Antagonist for the Treatment of Alzheimer’s Disease by Tanguturi, Parthasaradhi R., Ananthan, Subramaniam A., Pathak, Vibha, Venukadasula, Phanindra K., Zhang, Sixue, Chafiq, Omar Moukha, Szafran, Corinne E. A., Streicher, John M.

    Published in The FASEB journal (01-05-2022)
    “…Alzheimer’s disease (AD) is the most common form of dementia, which affects 47 million people worldwide. There are over five million AD patients over the age…”
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    Parallel Solution-Phase Synthesis and General Biological Activity of a Uridine Antibiotic Analog Library by Moukha-chafiq, Omar, Reynolds, Robert C

    Published in ACS combinatorial science (12-05-2014)
    “…A small library of ninety four uridine antibiotic analogs was synthesized, under the Pilot Scale Library (PSL) Program of the NIH Roadmap initiative, from…”
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    Parallel Solution Phase Synthesis and Preliminary Biological Activity of a 5′-Substituted Cytidine Analog Library by Moukha-Chafiq, Omar, Reynolds, Robert C, Wilson, Jacob C, Snowden, Timothy S

    Published in ACS combinatorial science (09-09-2019)
    “…A 109-membered library of 5′-substituted cytidine analogs was synthesized, via funding through the NIH Roadmap Initiative and the Pilot Scale Library (PSL)…”
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    Identification of quinazoline compounds as novel potent inhibitors of Wnt/β-catenin signaling in colorectal cancer cells by Li, Yonghe, Lu, Wenyan, Saini, Surendra K, Moukha-Chafiq, Omar, Pathak, Vibha, Ananthan, Subramaniam

    Published in Oncotarget (08-03-2016)
    “…The Wnt/β-catenin signaling pathway is critical for the initiation and progression of most colon cancers, and has emerged as one of the most promising targets…”
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    Journal Article