Search Results - "Chafin, Cristen B"

MicroRNAs Implicated in the Immunopathogenesis of Lupus Nephritis by Chafin, Cristen B., Reilly, Christopher M.

“…Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the deposition of immune complexes due to widespread loss of immune tolerance to…”
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Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosus by Shimp, Samuel K, Chafin, Cristen B, Regna, Nicole L, Hammond, Sarah E, Read, Molly A, Caudell, David L, Rylander, MarissaNichole, Reilly, Christopher M

“…Elevated expression of heat shock protein 90 (HSP90) has been found in kidneys and serum of systemic lupus erythematosus (SLE) patients and MRL/Mp- Fas lpr /…”
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Class I and II histone deacetylase inhibition by ITF2357 reduces SLE pathogenesis in vivo by Regna, Nicole L, Chafin, Cristen B, Hammond, Sarah E, Puthiyaveetil, Abdul G, Caudell, David L, Reilly, Christopher M

“…Abstract We sought to determine if a specific class I and II HDAC inhibitor (ITF2357) was able to decrease disease in lupus-prone NZB/W mice through regulation…”
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Specific HDAC6 inhibition by ACY-738 reduces SLE pathogenesis in NZB/W mice by Regna, Nicole L, Vieson, Miranda D, Luo, Xin M, Chafin, Cristen B, Puthiyaveetil, Abdul Gafoor, Hammond, Sarah E, Caudell, David L, Jarpe, Matthew B, Reilly, Christopher M

“…Abstract We sought to determine if a selective HDAC6 inhibitor (ACY-738) decreases disease in NZB/W mice. From 22 to 38 weeks-of-age, mice were injected…”
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Cellular and urinary microRNA alterations in NZB/W mice with hydroxychloroquine or prednisone treatment by Chafin, Cristen B., Regna, Nicole L., Hammond, Sarah E., Reilly, Christopher M.

“…Determining alterations to disease-associated miRNAs induced by specific therapeutics may allow the use of tailored therapy in lupus. We determined miRNA…”
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MicroRNA-let-7a expression is increased in the mesangial cells of NZB/W mice and increases IL-6 production in vitro by Chafin, Cristen B., Regna, Nicole L., Dai, Rujuan, Caudell, David L., Reilly, Christopher M.

“…Abstract Recent evidence supports a role for epigenetic alterations in the pathogenesis of systemic lupus erythematosus (SLE). MicroRNAs (miRNAs or miRs) are…”
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MicroRNA-let-7a promotes E2F-mediated cell proliferation and NFκB activation in vitro by Chafin, Cristen B, Regna, Nicole L, Caudell, David L, Reilly, Christopher M

“…Epigenetic factors, including altered microRNA (miRNA) expression, may contribute to aberrant immune cell function in systemic lupus erythematosus (SLE)…”
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HSP90 inhibition by 17-DMAG reduces inflammation in J774 macrophages through suppression of Akt and nuclear factor-κB pathways by Shimp, Samuel K., Parson, Carl D., Regna, Nicole L., Thomas, Alicia N., Chafin, Cristen B., Reilly, Christopher M., Nichole Rylander, M.

“…Objective This study was designed to determine whether inhibition of heat shock protein 90 (HSP90) reduces pro-inflammatory mediator production by decreasing…”
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MicroRNA-let-7a promotes E2F-mediated cell proliferation and NF[kappa]B activation in vitro by Chafin, Cristen B, Regna, Nicole L, Caudell, David L, Reilly, Christopher M

“…Epigenetic factors, including altered microRNA (miRNA) expression, may contribute to aberrant immune cell function in systemic lupus erythematosus (SLE)…”
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MicroRNA-let-7a promotes E2F-mediated cell proliferation and NFKB activation in vitro by Cristen B Chafin Nicole L Regna David L Caudell Christopher M Reilly

“…Epigenetic factors, including altered microRNA （miRNA） expression, may contribute to aberrant immune cell function in systemic lupus erythematosus （SLE）…”
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HSP90 inhibition by 17-DMAG reduces inflammation in J774 macrophages through suppression of Akt and nuclear factor-[kappa]B pathways by Shimp, Samuel K, Parson, Carl D, Regna, Nicole L, Thomas, Alicia N, Chafin, Cristen B, Reilly, Christopher M, Nichole Rylander, M

“…This study was designed to determine whether inhibition of heat shock protein 90 (HSP90) reduces pro-inflammatory mediator production by decreasing the nuclear…”
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MicroRNA-mediated Attenuation of Inflammation in NZB/W Lupus Mice by Chafin, Cristen B

“…Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production and deposition of nuclear self-antigen-containing immune complexes…”
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Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus by Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly

“…Elevated expression of heat shock protein 90 （HSP90） has been found in kidneys and serum of systemic lupus erythematosus （SLE） patients and…”
Get full text

MicroRNAs Implicated in the Immunopathogenesis of Lupus Nephritis by Chafin, Cristen B., Reilly, Christopher M.

“…Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the deposition of immune complexes due to widespread loss of immune tolerance to…”
Get full text