Search Results - "Chaffin, Mark D"

A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases by Zhu, Zhaozhong, Lee, Phil H., Chaffin, Mark D., Chung, Wonil, Loh, Po-Ru, Lu, Quan, Christiani, David C., Liang, Liming

“…Clinical and epidemiological data suggest that asthma and allergic diseases are associated and may share a common genetic etiology. We analyzed genome-wide SNP…”
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Genomic and metabolic diversity of Marine Group I Thaumarchaeota in the mesopelagic of two subtropical gyres by Swan, Brandon K, Chaffin, Mark D, Martinez-Garcia, Manuel, Morrison, Hilary G, Field, Erin K, Poulton, Nicole J, Masland, E Dashiell P, Harris, Christopher C, Sczyrba, Alexander, Chain, Patrick S G, Koren, Sergey, Woyke, Tanja, Stepanauskas, Ramunas

“…Marine Group I (MGI) Thaumarchaeota are one of the most abundant and cosmopolitan chemoautotrophs within the global dark ocean. To date, no representatives of…”
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Transfer learning enables predictions in network biology by Theodoris, Christina V., Xiao, Ling, Chopra, Anant, Chaffin, Mark D., Al Sayed, Zeina R., Hill, Matthew C., Mantineo, Helene, Brydon, Elizabeth M., Zeng, Zexian, Liu, X. Shirley, Ellinor, Patrick T.

“…Mapping gene networks requires large amounts of transcriptomic data to learn the connections between genes, which impedes discoveries in settings with limited…”
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Unsupervised removal of systematic background noise from droplet-based single-cell experiments using CellBender by Fleming, Stephen J., Chaffin, Mark D., Arduini, Alessandro, Akkad, Amer-Denis, Banks, Eric, Marioni, John C., Philippakis, Anthony A., Ellinor, Patrick T., Babadi, Mehrtash

“…Droplet-based single-cell assays, including single-cell RNA sequencing (scRNA-seq), single-nucleus RNA sequencing (snRNA-seq) and cellular indexing of…”
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Deep learning enables genetic analysis of the human thoracic aorta by Pirruccello, James P., Chaffin, Mark D., Chou, Elizabeth L., Fleming, Stephen J., Lin, Honghuang, Nekoui, Mahan, Khurshid, Shaan, Friedman, Samuel F., Bick, Alexander G., Arduini, Alessandro, Weng, Lu-Chen, Choi, Seung Hoan, Akkad, Amer-Denis, Batra, Puneet, Tucker, Nathan R., Hall, Amelia W., Roselli, Carolina, Benjamin, Emelia J., Vellarikkal, Shamsudheen K., Gupta, Rajat M., Stegmann, Christian M., Juric, Dejan, Stone, James R., Vasan, Ramachandran S., Ho, Jennifer E., Hoffmann, Udo, Lubitz, Steven A., Philippakis, Anthony A., Lindsay, Mark E., Ellinor, Patrick T.

“…Enlargement or aneurysm of the aorta predisposes to dissection, an important cause of sudden death. We trained a deep learning model to evaluate the dimensions…”
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The Genetic Determinants of Aortic Distention by Pirruccello, James P., Rämö, Joel T., Choi, Seung Hoan, Chaffin, Mark D., Kany, Shinwan, Nekoui, Mahan, Chou, Elizabeth L., Jurgens, Sean J., Friedman, Samuel F., Juric, Dejan, Stone, James R., Batra, Puneet, Ng, Kenney, Philippakis, Anthony A., Lindsay, Mark E., Ellinor, Patrick T.

“…As the largest conduit vessel, the aorta is responsible for the conversion of phasic systolic inflow from ventricular ejection into more continuous peripheral…”
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Author Correction: A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases by Zhu, Zhaozhong, Lee, Phil H., Chaffin, Mark D., Chung, Wonil, Loh, Po-Ru, Lu, Quan, Christiani, David C., Liang, Liming

“…In the version of this article originally published, there were two errors in the text of the second paragraph of the Methods section. In the sentence “To…”
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MetProc: Separating Measurement Artifacts from True Metabolites in an Untargeted Metabolomics Experiment by Chaffin, Mark D, Cao, Liu, Deik, Amy A, Clish, Clary B, Hu, Frank B, Martínez-González, Miguel A, Razquin, Cristina, Bullo, Monica, Corella, Dolores, Gómez-Gracia, Enrique, Fiol, Miquel, Estruch, Ramon, Lapetra, José, Fitó, Montserrat, Arós, Fernando, Serra-Majem, Lluís, Ros, Emilio, Liang, Liming

“…High-throughput metabolomics using liquid chromatography and mass spectrometry (LC/MS) provides a useful method to identify biomarkers of disease and explore…”
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SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart by Valkov, Nedyalka, Das, Avash, Tucker, Nathan R, Li, Guoping, Salvador, Ane M, Chaffin, Mark D, Pereira De Oliveira Junior, Getulio, Kur, Ivan, Gokulnath, Priyanka, Ziegler, Olivia, Yeri, Ashish, Lu, Shulin, Khamesra, Aushee, Xiao, Chunyang, Rodosthenous, Rodosthenis, Srinivasan, Srimeenakshi, Toxavidis, Vasilis, Tigges, John, Laurent, Louise C, Momma, Stefan, Kitchen, Robert, Ellinor, Patrick, Ghiran, Ionita, Das, Saumya

“…Extracellular vesicles (EVs) mediate intercellular signaling by transferring their cargo to recipient cells, but the functional consequences of signaling are…”
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Rare Coding Variants Associated With Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-Ancestry Analysis by Choi, Seung Hoan, Jurgens, Sean J., Haggerty, Christopher M., Hall, Amelia W., Halford, Jennifer L., Morrill, Valerie N., Weng, Lu-Chen, Lagerman, Braxton, Mirshahi, Tooraj, Pettinger, Mary, Guo, Xiuqing, Lin, Henry J., Alonso, Alvaro, Soliman, Elsayed Z., Kornej, Jelena, Lin, Honghuang, Moscati, Arden, Nadkarni, Girish N., Brody, Jennifer A., Wiggins, Kerri L., Cade, Brian E., Lee, Jiwon, Austin-Tse, Christina, Blackwell, Tom, Chaffin, Mark D., Lee, Christina J.-Y., Rehm, Heidi L., Roselli, Carolina, Redline, Susan, Mitchell, Braxton D., Sotoodehnia, Nona, Psaty, Bruce M., Heckbert, Susan R., Loos, Ruth J.F., Vasan, Ramachandran S., Benjamin, Emelia J., Correa, Adolfo, Boerwinkle, Eric, Arking, Dan E., Rotter, Jerome I., Rich, Stephen S., Whitsel, Eric A., Perez, Marco, Kooperberg, Charles, Fornwalt, Brandon K., Lunetta, Kathryn L., Ellinor, Patrick T., Lubitz, Steven A.

“…Alterations in electrocardiographic (ECG) intervals are well-known markers for arrhythmia and sudden cardiac death (SCD) risk. While the genetics of arrhythmia…”
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The Genetic Determinants of Aortic Distension by Pirruccello, James P., Rämö, Joel T., Hoan Choi, Seung, Chaffin, Mark D., Kany, Shinwan, Nekoui, Mahan, Chou, Elizabeth L., Jurgens, Sean J., Friedman, Samuel F., Juric, Dejan, Stone, James R., Batra, Puneet, Ng, Kenney, Philippakis, Anthony A., Lindsay, Mark E., Ellinor, Patrick T.

“…We trained a deep learning model to quantify aortic distensibility and strain from cardiac magnetic resonance imaging in 42,342 UK Biobank participants…”
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Deep learning enables genetic analysis of the human thoracic aorta by Pirruccello, James P, Chaffin, Mark D, Chou, Elizabeth L, Fleming, Stephen J, Lin, Honghuang, Nekoui, Mahan, Khurshid, Shaan, Friedman, Samuel F, Bick, Alexander G, Arduini, Alessandro, Weng, Lu-Chen, Choi, Seung Hoan, Akkad, Amer-Denis, Batra, Puneet, Tucker, Nathan R, Hall, Amelia W, Roselli, Carolina, Benjamin, Emelia J, Vellarikkal, Shamsudheen K, Gupta, Rajat M, Stegmann, Christian M, Juric, Dejan, Stone, James R, Vasan, Ramachandran S, Ho, Jennifer E, Hoffmann, Udo, Lubitz, Steven A, Philippakis, Anthony A, Lindsay, Mark E, Ellinor, Patrick T

“…Enlargement or aneurysm of the aorta predisposes to dissection, an important cause of sudden death. We trained a deep learning model to evaluate the dimensions…”
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Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience by Jurgens, Sean J, Rämö, Joel T, Kramarenko, Daria R, Wijdeveld, Leonoor F J M, Haas, Jan, Chaffin, Mark D, Garnier, Sophie, Gaziano, Liam, Weng, Lu-Chen, Lipov, Alex, Zheng, Sean L, Henry, Albert, Huffman, Jennifer E, Challa, Saketh, Rühle, Frank, Verdugo, Carmen Diaz, Krijger Juárez, Christian, Kany, Shinwan, van Orsouw, Constance A, Biddinger, Kiran, Poel, Edwin, Elliott, Amanda L, Wang, Xin, Francis, Catherine, Ruan, Richard, Koyama, Satoshi, Beekman, Leander, Zimmerman, Dominic S, Deleuze, Jean-François, Villard, Eric, Trégouët, David-Alexandre, Isnard, Richard, Boomsma, Dorret I, de Geus, Eco J C, Tadros, Rafik, Pinto, Yigal M, Wilde, Arthur A M, Hottenga, Jouke-Jan, Sinisalo, Juha, Niiranen, Teemu, Walsh, Roddy, Schmidt, Amand F, Choi, Seung Hoan, Chang, Kyong-Mi, Tsao, Philip S, Matthews, Paul M, Ware, James S, Lumbers, R Thomas, van der Crabben, Saskia, Laukkanen, Jari, Palotie, Aarno, Amin, Ahmad S, Charron, Philippe, Meder, Benjamin, Ellinor, Patrick T, Daly, Mark, Aragam, Krishna G, Bezzina, Connie R

“…Dilated cardiomyopathy (DCM) is a heart muscle disease that represents an important cause of morbidity and mortality, yet causal mechanisms remain largely…”
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Genomic and Metabolic Diversity of Marine Group I Thaumarchaeota in the Mesopelagic of Two Subtropical Gyres: e95380 by Swan, Brandon K, Chaffin, Mark D, Martinez-Garcia, Manuel, Morrison, Hilary G, Field, Erin K, Poulton, Nicole J, Masland, E DashiellP, Harris, Christopher C, Sczyrba, Alexander, Chain, Patrick SG

“…Marine Group I (MGI) Thaumarchaeota are one of the most abundant and cosmopolitan chemoautotrophs within the global dark ocean. To date, no representatives of…”
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