Search Results - "Chaffee, Stuart C."

Evolution of a Highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor by Hodous, Brian L, Geuns-Meyer, Stephanie D, Hughes, Paul E, Albrecht, Brian K, Bellon, Steve, Bready, James, Caenepeel, Sean, Cee, Victor J, Chaffee, Stuart C, Coxon, Angela, Emery, Maurice, Fretland, Jenne, Gallant, Paul, Gu, Yan, Hoffman, Doug, Johnson, Rebecca E, Kendall, Richard, Kim, Joseph L, Long, Alexander M, Morrison, Michael, Olivieri, Philip R, Patel, Vinod F, Polverino, Anthony, Rose, Paul, Tempest, Paul, Wang, Ling, Whittington, Douglas A, Zhao, Huilin

“…Inhibition of angiogenesis is a promising and clinically validated approach for limiting tumor growth and survival. The receptor tyrosine kinase Tie-2 is…”
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Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors by Hodous, Brian L., Geuns-Meyer, Stephanie D., Hughes, Paul E., Albrecht, Brian K., Bellon, Steve, Caenepeel, Sean, Cee, Victor J., Chaffee, Stuart C., Emery, Maurice, Fretland, Jenne, Gallant, Paul, Gu, Yan, Johnson, Rebecca E., Kim, Joseph L., Long, Alexander M., Morrison, Michael, Olivieri, Philip R., Patel, Vinod F., Polverino, Anthony, Rose, Paul, Wang, Ling, Zhao, Huilin

“…A novel class of selective Tie-2 inhibitors was derived from a multi-kinase inhibitor 1. By reversing the amide connectivity and incorporating aminotriazine or…”
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Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors by Buchanan, John L., Newcomb, John R., Carney, David P., Chaffee, Stuart C., Chai, Lilly, Cupples, Rod, Epstein, Linda F., Gallant, Paul, Gu, Yan, Harmange, Jean-Christophe, Hodge, Kathy, Houk, Brett E., Huang, Xin, Jona, Janan, Joseph, Smriti, Jun, H. Toni, Kumar, Rakesh, Li, Chun, Lu, John, Menges, Tom, Morrison, Michael J., Novak, Perry M., van der Plas, Simon, Radinsky, Robert, Rose, Paul E., Sawant, Satin, Sun, Ji-Rong, Surapaneni, Sekhar, Turci, Susan M., Xu, Keyang, Yanez, Evelyn, Zhao, Huilin, Zhu, Xiaotian

“…The discovery of 2,4-bis-arylamino-1,3-pyrimidines as IGF-1R inhibitors is described. Optimization studies led to the identification of 26, which displayed…”
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Structure-Guided Design of Aminopyrimidine Amides as Potent, Selective Inhibitors of Lymphocyte Specific Kinase: Synthesis, Structure–Activity Relationships, and Inhibition of in Vivo T Cell Activation by DiMauro, Erin F, Newcomb, John, Nunes, Joseph J, Bemis, Jean E, Boucher, Christina, Chai, Lilly, Chaffee, Stuart C, Deak, Holly L, Epstein, Linda F, Faust, Ted, Gallant, Paul, Gore, Anu, Gu, Yan, Henkle, Brad, Hsieh, Faye, Huang, Xin, Kim, Joseph L, Lee, Josie H, Martin, Matthew W, McGowan, David C, Metz, Daniela, Mohn, Deanna, Morgenstern, Kurt A, Oliveira-dos-Santos, Antonio, Patel, Vinod F, Powers, David, Rose, Paul E, Schneider, Stephen, Tomlinson, Susan A, Tudor, Yan-Yan, Turci, Susan M, Welcher, Andrew A, Zhao, Huilin, Zhu, Li, Zhu, Xiaotian

“…The lymphocyte-specific kinase (Lck), a member of the Src family of cytoplasmic tyrosine kinases, is expressed in T cells and natural killer (NK) cells…”
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Alkynylpyrimidine Amide Derivatives as Potent, Selective, and Orally Active Inhibitors of Tie-2 Kinase by Cee, Victor J, Albrecht, Brian K, Geuns-Meyer, Stephanie, Hughes, Paul, Bellon, Steve, Bready, James, Caenepeel, Sean, Chaffee, Stuart C, Coxon, Angela, Emery, Maurice, Fretland, Jenne, Gallant, Paul, Gu, Yan, Hodous, Brian L, Hoffman, Doug, Johnson, Rebecca E, Kendall, Richard, Kim, Joseph L, Long, Alexander M, McGowan, David, Morrison, Michael, Olivieri, Philip R, Patel, Vinod F, Polverino, Anthony, Powers, David, Rose, Paul, Wang, Ling, Zhao, Huilin

“…The recognition that aberrant angiogenesis contributes to the pathology of inflammatory diseases, cancer, and myocardial ischemia has generated considerable…”
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Improved Synthesis of [Mn(CO)5OClO3], a Versatile Reagent for the Preparation of Cationic (Polyene)manganese(I) Complexes. Crystal Structure of [(η4-1,5-Cyclooctadiene)Mn(CO)4]ClO4 by Chaffee, Stuart C, Sutton, Joshua C, Babbitt, Clifford S, Maeyer, Jonathan T, Guy, Kathryn A, Pike, Robert D, Carpenter, Gene B

“…The title complex is synthesized in one step from [Mn2(CO)10] and is used to prepare cationic [(η4-diene)Mn(CO)4]+ and [(η6-triene)Mn(CO)3]+ complexes,…”
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Improved Synthesis of [Mn(CO) 5 OClO 3 ], a Versatile Reagent for the Preparation of Cationic (Polyene)manganese(I) Complexes. Crystal Structure of [(η 4 -1,5-Cyclooctadiene)Mn(CO) 4 ]ClO 4 by Chaffee, Stuart C., Sutton, Joshua C., Babbitt, Clifford S., Maeyer, Jonathan T., Guy, Kathryn A., Pike, Robert D., Carpenter, Gene B.

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