Search Results - "Chadwick, Alexandra C."

In Vivo Base Editing of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) as a Therapeutic Alternative to Genome Editing by Chadwick, Alexandra C, Wang, Xiao, Musunuru, Kiran

“…OBJECTIVE—High-efficiency genome editing to disrupt therapeutic target genes, such as PCSK9 (proprotein convertase subtilisin/kexin type 9), has been…”
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In utero CRISPR-mediated therapeutic editing of metabolic genes by Rossidis, Avery C., Stratigis, John D., Chadwick, Alexandra C., Hartman, Heather A., Ahn, Nicholas J., Li, Haiying, Singh, Kshitiz, Coons, Barbara E., Li, Li, Lv, Wenjian, Zoltick, Philip W., Alapati, Deepthi, Zacharias, William, Jain, Rajan, Morrisey, Edward E., Musunuru, Kiran, Peranteau, William H.

“…In utero gene editing has the potential to prenatally treat genetic diseases that result in significant morbidity and mortality before or shortly after birth…”
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Functional characterization of newly-discovered mutations in human SR-BI by Chadwick, Alexandra C, Sahoo, Daisy

“…In rodents, SR-BI has been firmly established as a physiologically relevant HDL receptor that mediates removal of HDL-cholesteryl esters (CE). However, its…”
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Acrolein impairs the cholesterol transport functions of high density lipoproteins by Chadwick, Alexandra C, Holme, Rebecca L, Chen, Yiliang, Thomas, Michael J, Sorci-Thomas, Mary G, Silverstein, Roy L, Pritchard, Jr, Kirkwood A, Sahoo, Daisy

“…High density lipoproteins (HDL) are considered athero-protective, primarily due to their role in reverse cholesterol transport, where they transport…”
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Reduced Blood Lipid Levels With In Vivo CRISPR-Cas9 Base Editing of ANGPTL3 by Chadwick, Alexandra C, Evitt, Niklaus H, Lv, Wenjian, Musunuru, Kiran

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CRISPR-Cas9 Genome Editing for Treatment of Atherogenic Dyslipidemia by Chadwick, Alexandra C, Musunuru, Kiran

“…Although human genetics has resulted in the identification of novel lipid-related genes that can be targeted for the prevention of atherosclerotic vascular…”
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In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates by Musunuru, Kiran, Chadwick, Alexandra C., Mizoguchi, Taiji, Garcia, Sara P., DeNizio, Jamie E., Reiss, Caroline W., Wang, Kui, Iyer, Sowmya, Dutta, Chaitali, Clendaniel, Victoria, Amaonye, Michael, Beach, Aaron, Berth, Kathleen, Biswas, Souvik, Braun, Maurine C., Chen, Huei-Mei, Colace, Thomas V., Ganey, John D., Gangopadhyay, Soumyashree A., Garrity, Ryan, Kasiewicz, Lisa N., Lavoie, Jennifer, Madsen, James A., Matsumoto, Yuri, Mazzola, Anne Marie, Nasrullah, Yusuf S., Nneji, Joseph, Ren, Huilan, Sanjeev, Athul, Shay, Madeleine, Stahley, Mary R., Fan, Steven H. Y., Tam, Ying K., Gaudelli, Nicole M., Ciaramella, Giuseppe, Stolz, Leslie E., Malyala, Padma, Cheng, Christopher J., Rajeev, Kallanthottathil G., Rohde, Ellen, Bellinger, Andrew M., Kathiresan, Sekar

“…Gene-editing technologies, which include the CRISPR–Cas nucleases 1 – 3 and CRISPR base editors 4 , 5 , have the potential to permanently modify…”
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Inhibition of an NAD+ Salvage Pathway Provides Efficient and Selective Toxicity to Human Pluripotent Stem Cells by Kropp, Erin M., Oleson, Bryndon J., Broniowska, Katarzyna A., Bhattacharya, Subarna, Chadwick, Alexandra C., Diers, Anne R., Hu, Qinghui, Sahoo, Daisy, Hogg, Neil, Boheler, Kenneth R., Corbett, John A., Gundry, Rebekah L.

“…The tumorigenic potential of human pluripotent stem cells (hPSCs) is a major limitation to the widespread use of hPSC derivatives in the clinic. Here, we…”
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In utero gene editing for monogenic lung disease by Alapati, Deepthi, Zacharias, William J, Hartman, Heather A, Rossidis, Avery C, Stratigis, John D, Ahn, Nicholas J, Coons, Barbara, Zhou, Su, Li, Hiaying, Singh, Kshitiz, Katzen, Jeremy, Tomer, Yaniv, Chadwick, Alexandra C, Musunuru, Kiran, Beers, Michael F, Morrisey, Edward E, Peranteau, William H

“…Monogenic lung diseases that are caused by mutations in surfactant genes of the pulmonary epithelium are marked by perinatal lethal respiratory failure or…”
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Treatment of Dyslipidemia Using CRISPR/Cas9 Genome Editing by Chadwick, Alexandra C., Musunuru, Kiran

“…Purpose of Review Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated 9 (Cas9) has recently emerged as a top genome editing…”
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Genome Editing for the Study of Cardiovascular Diseases by Chadwick, Alexandra C., Musunuru, Kiran

“…Purpose of Review The opportunities afforded through the recent advent of genome-editing technologies have allowed investigators to more easily study a number…”
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Oxidized LDL-bound CD36 recruits an Na⁺/K⁺-ATPase-Lyn complex in macrophages that promotes atherosclerosis by Chen, Yiliang, Kennedy, David J, Ramakrishnan, Devi Prasadh, Yang, Moua, Huang, Wenxin, Li, Zhichuan, Xie, Zijian, Chadwick, Alexandra C, Sahoo, Daisy, Silverstein, Roy L

“…One characteristic of atherosclerosis is the accumulation of lipid-laden macrophage foam cells in the arterial wall. We have previously shown that the binding…”
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Impairment of Macrophage Cholesterol Efflux by Cholesterol Hydroperoxide Trafficking: Implications for Atherogenesis Under Oxidative Stress by Korytowski, Witold, Wawak, Katarzyna, Pabisz, Pawel, Schmitt, Jared C, Chadwick, Alexandra C, Sahoo, Daisy, Girotti, Albert W

“…Oxidative stress associated with cardiovascular disease can produce various oxidized lipids, including cholesterol oxides, such as 7-hydroperoxide (7-OOH),…”
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CD8+ Foxp3+ regulatory T cells are induced during graft-versus-host disease and mitigate disease severity by Beres, Amy J, Haribhai, Dipica, Chadwick, Alexandra C, Gonyo, Patrick J, Williams, Calvin B, Drobyski, William R

“…Regulatory T cells (Tregs), in particular CD4(+) Foxp3(+) T cells, have been shown to play an important role in the maintenance of tolerance after allogeneic…”
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NMR Structure of the C-Terminal Transmembrane Domain of the HDL Receptor, SR-BI, and a Functionally Relevant Leucine Zipper Motif by Chadwick, Alexandra C., Jensen, Davin R., Hanson, Paul J., Lange, Philip T., Proudfoot, Sarah C., Peterson, Francis C., Volkman, Brian F., Sahoo, Daisy

“…The interaction of high-density lipoprotein (HDL) with its receptor, scavenger receptor BI (SR-BI), is critical for lowering plasma cholesterol levels and…”
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Functional genomics of the human high-density lipoprotein receptor scavenger receptor BI: an old dog with new tricks by Chadwick, Alexandra C., Sahoo, Daisy

“…The athero-protective role of scavenger receptor BI (SR-BI) is primarily attributed to its ability to selectively transfer cholesteryl esters from high-density…”
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Expression, purification and reconstitution of the C-terminal transmembrane domain of scavenger receptor BI into detergent micelles for NMR analysis by Chadwick, Alexandra C., Jensen, Davin R., Peterson, Francis C., Volkman, Brian F., Sahoo, Daisy

“…•SR-BI is an HDL receptor that regulates whole body cholesterol removal.•SR-BI’s C-terminal transmembrane domain was recombinantly expressed and…”
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Abstract 55: Disruption of PCSK9 Using a Targeted Base Editing Strategy by Chadwick, Alexandra C, Musunuru, Kiran

“…Abstract only Proprotein convertase subtilisin/kexin type 9 (PCSK9) increases blood low-density lipoprotein (LDL) cholesterol by acting as an LDL receptor…”
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Abstract 214: Functional Analysis of the Low Density Lipoprotein Receptor Using Saturation Mutagenesis Strategies by Chadwick, Alexandra C, Evitt, Niklaus H, Musunuru, Kiran

“…Abstract only Low density lipoprotein receptor (LDLR) genetic mutations are well-documented to cause familial hypercholesterolemia (FH) in patients. These…”
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Abstract 563: Working Out the Kinks of SR-BI-mediated Cholesterol Transport by Proudfoot, Sarah C, Chadwick, Alexandra C, Sahoo, Daisy

“…Abstract only High density lipoproteins (HDL) facilitate reverse cholesterol transport (RCT), the process by which cholesterol effluxed from peripheral tissues…”
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