Search Results - "Chadwick, Alexandra"

In Vivo Base Editing of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) as a Therapeutic Alternative to Genome Editing by Chadwick, Alexandra C, Wang, Xiao, Musunuru, Kiran

“…OBJECTIVE—High-efficiency genome editing to disrupt therapeutic target genes, such as PCSK9 (proprotein convertase subtilisin/kexin type 9), has been…”
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Reduced Blood Lipid Levels With In Vivo CRISPR-Cas9 Base Editing of ANGPTL3 by Chadwick, Alexandra C, Evitt, Niklaus H, Lv, Wenjian, Musunuru, Kiran

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Functional characterization of newly-discovered mutations in human SR-BI by Chadwick, Alexandra C, Sahoo, Daisy

“…In rodents, SR-BI has been firmly established as a physiologically relevant HDL receptor that mediates removal of HDL-cholesteryl esters (CE). However, its…”
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CRISPR-Cas9 Genome Editing for Treatment of Atherogenic Dyslipidemia by Chadwick, Alexandra C, Musunuru, Kiran

“…Although human genetics has resulted in the identification of novel lipid-related genes that can be targeted for the prevention of atherosclerotic vascular…”
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In utero CRISPR-mediated therapeutic editing of metabolic genes by Rossidis, Avery C., Stratigis, John D., Chadwick, Alexandra C., Hartman, Heather A., Ahn, Nicholas J., Li, Haiying, Singh, Kshitiz, Coons, Barbara E., Li, Li, Lv, Wenjian, Zoltick, Philip W., Alapati, Deepthi, Zacharias, William, Jain, Rajan, Morrisey, Edward E., Musunuru, Kiran, Peranteau, William H.

“…In utero gene editing has the potential to prenatally treat genetic diseases that result in significant morbidity and mortality before or shortly after birth…”
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In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates by Musunuru, Kiran, Chadwick, Alexandra C., Mizoguchi, Taiji, Garcia, Sara P., DeNizio, Jamie E., Reiss, Caroline W., Wang, Kui, Iyer, Sowmya, Dutta, Chaitali, Clendaniel, Victoria, Amaonye, Michael, Beach, Aaron, Berth, Kathleen, Biswas, Souvik, Braun, Maurine C., Chen, Huei-Mei, Colace, Thomas V., Ganey, John D., Gangopadhyay, Soumyashree A., Garrity, Ryan, Kasiewicz, Lisa N., Lavoie, Jennifer, Madsen, James A., Matsumoto, Yuri, Mazzola, Anne Marie, Nasrullah, Yusuf S., Nneji, Joseph, Ren, Huilan, Sanjeev, Athul, Shay, Madeleine, Stahley, Mary R., Fan, Steven H. Y., Tam, Ying K., Gaudelli, Nicole M., Ciaramella, Giuseppe, Stolz, Leslie E., Malyala, Padma, Cheng, Christopher J., Rajeev, Kallanthottathil G., Rohde, Ellen, Bellinger, Andrew M., Kathiresan, Sekar

“…Gene-editing technologies, which include the CRISPR–Cas nucleases 1 – 3 and CRISPR base editors 4 , 5 , have the potential to permanently modify…”
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In utero gene editing for monogenic lung disease by Alapati, Deepthi, Zacharias, William J, Hartman, Heather A, Rossidis, Avery C, Stratigis, John D, Ahn, Nicholas J, Coons, Barbara, Zhou, Su, Li, Hiaying, Singh, Kshitiz, Katzen, Jeremy, Tomer, Yaniv, Chadwick, Alexandra C, Musunuru, Kiran, Beers, Michael F, Morrisey, Edward E, Peranteau, William H

“…Monogenic lung diseases that are caused by mutations in surfactant genes of the pulmonary epithelium are marked by perinatal lethal respiratory failure or…”
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GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy by Kasiewicz, Lisa N., Biswas, Souvik, Beach, Aaron, Ren, Huilan, Dutta, Chaitali, Mazzola, Anne Marie, Rohde, Ellen, Chadwick, Alexandra, Cheng, Christopher, Garcia, Sara P., Iyer, Sowmya, Matsumoto, Yuri, Khera, Amit V., Musunuru, Kiran, Kathiresan, Sekar, Malyala, Padma, Rajeev, Kallanthottathil G., Bellinger, Andrew M.

“…Lipid nanoparticles have demonstrated utility in hepatic delivery of a range of therapeutic modalities and typically deliver their cargo via low-density…”
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Acrolein impairs the cholesterol transport functions of high density lipoproteins by Chadwick, Alexandra C, Holme, Rebecca L, Chen, Yiliang, Thomas, Michael J, Sorci-Thomas, Mary G, Silverstein, Roy L, Pritchard, Jr, Kirkwood A, Sahoo, Daisy

“…High density lipoproteins (HDL) are considered athero-protective, primarily due to their role in reverse cholesterol transport, where they transport…”
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Treatment of Dyslipidemia Using CRISPR/Cas9 Genome Editing by Chadwick, Alexandra C., Musunuru, Kiran

“…Purpose of Review Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated 9 (Cas9) has recently emerged as a top genome editing…”
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Genome Editing for the Study of Cardiovascular Diseases by Chadwick, Alexandra C., Musunuru, Kiran

“…Purpose of Review The opportunities afforded through the recent advent of genome-editing technologies have allowed investigators to more easily study a number…”
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Oxidized LDL-bound CD36 recruits an Na⁺/K⁺-ATPase-Lyn complex in macrophages that promotes atherosclerosis by Chen, Yiliang, Kennedy, David J, Ramakrishnan, Devi Prasadh, Yang, Moua, Huang, Wenxin, Li, Zhichuan, Xie, Zijian, Chadwick, Alexandra C, Sahoo, Daisy, Silverstein, Roy L

“…One characteristic of atherosclerosis is the accumulation of lipid-laden macrophage foam cells in the arterial wall. We have previously shown that the binding…”
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Impairment of Macrophage Cholesterol Efflux by Cholesterol Hydroperoxide Trafficking: Implications for Atherogenesis Under Oxidative Stress by Korytowski, Witold, Wawak, Katarzyna, Pabisz, Pawel, Schmitt, Jared C, Chadwick, Alexandra C, Sahoo, Daisy, Girotti, Albert W

“…Oxidative stress associated with cardiovascular disease can produce various oxidized lipids, including cholesterol oxides, such as 7-hydroperoxide (7-OOH),…”
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CD8+ Foxp3+ regulatory T cells are induced during graft-versus-host disease and mitigate disease severity by Beres, Amy J, Haribhai, Dipica, Chadwick, Alexandra C, Gonyo, Patrick J, Williams, Calvin B, Drobyski, William R

“…Regulatory T cells (Tregs), in particular CD4(+) Foxp3(+) T cells, have been shown to play an important role in the maintenance of tolerance after allogeneic…”
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NMR Structure of the C-Terminal Transmembrane Domain of the HDL Receptor, SR-BI, and a Functionally Relevant Leucine Zipper Motif by Chadwick, Alexandra C., Jensen, Davin R., Hanson, Paul J., Lange, Philip T., Proudfoot, Sarah C., Peterson, Francis C., Volkman, Brian F., Sahoo, Daisy

“…The interaction of high-density lipoprotein (HDL) with its receptor, scavenger receptor BI (SR-BI), is critical for lowering plasma cholesterol levels and…”
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Functional genomics of the human high-density lipoprotein receptor scavenger receptor BI: an old dog with new tricks by Chadwick, Alexandra C., Sahoo, Daisy

“…The athero-protective role of scavenger receptor BI (SR-BI) is primarily attributed to its ability to selectively transfer cholesteryl esters from high-density…”
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Where is the History of Political Thought Going? by John Dunn, Humeira Iqtidar, Iain Hampsher-Monk, Richard Bourke, Adrian Blau, Alexandra Chadwick, Duncan Kelly, David Leopold, Peter Burke, Richard Whatmore

“…After the recent publication of a couple of succinct and overarching essays covering the state of the field in the history of political thought (in the English…”
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Expression, purification and reconstitution of the C-terminal transmembrane domain of scavenger receptor BI into detergent micelles for NMR analysis by Chadwick, Alexandra C., Jensen, Davin R., Peterson, Francis C., Volkman, Brian F., Sahoo, Daisy

“…•SR-BI is an HDL receptor that regulates whole body cholesterol removal.•SR-BI’s C-terminal transmembrane domain was recombinantly expressed and…”
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Inhibition of an NAD+ Salvage Pathway Provides Efficient and Selective Toxicity to Human Pluripotent Stem Cells by Kropp, Erin M., Oleson, Bryndon J., Broniowska, Katarzyna A., Bhattacharya, Subarna, Chadwick, Alexandra C., Diers, Anne R., Hu, Qinghui, Sahoo, Daisy, Hogg, Neil, Boheler, Kenneth R., Corbett, John A., Gundry, Rebekah L.

“…The tumorigenic potential of human pluripotent stem cells (hPSCs) is a major limitation to the widespread use of hPSC derivatives in the clinic. Here, we…”
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Excessive self-esteem, and the social consequences of Mandeville’s analysis: a comment on Robin Douglass’s Mandeville’s Fable by Chadwick, Alexandra

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