Search Results - "Chaddock, Christopher A."

Neural and Behavioral Correlates of Aberrant Salience in Individuals at Risk for Psychosis by ROISER, Jonathan P, HOWES, Oliver D, CHADDOCK, Christopher A, JOYCE, Eileen M, MCGUIRE, Philip

“…The "aberrant salience" model proposes that psychotic symptoms first emerge when chaotic brain dopamine transmission leads to the attribution of significance…”
Get full text

Presynaptic Striatal Dopamine Dysfunction in People at Ultra-high Risk for Psychosis: Findings in a Second Cohort by Egerton, Alice, Chaddock, Christopher A, Winton-Brown, Toby T, Bloomfield, Michael A.P, Bhattacharyya, Sagnik, Allen, Paul, McGuire, Philip K, Howes, Oliver D

“…Background Using positron emission tomography (PET), we previously observed increases in 3,4-dihydroxy-6-[18 F]fluoro-L-phenylalanine (18 F-DOPA) uptake in the…”
Get full text

White matter abnormalities and illness severity in major depressive disorder by Cole, James, Chaddock, Christopher A., Farmer, Anne E., Aitchison, Katherine J., Simmons, Andrew, McGuffin, Peter, Fu, Cynthia H. Y.

“…White matter abnormalities have been implicated in the aetiology of major depressive disorder; however, the relationship between the severity of symptoms and…”
Get full text

Relationship between brain glutamate levels and clinical outcome in individuals at ultra high risk of psychosis by Egerton, Alice, Stone, James M, Chaddock, Christopher A, Barker, Gareth J, Bonoldi, Ilaria, Howard, Rachel M, Merritt, Kate, Allen, Paul, Howes, Oliver D, Murray, Robin M, McLean, Mary A, Lythgoe, David J, O'Gorman, Ruth L, McGuire, Philip K

“…Alterations in brain glutamate levels may be associated with psychosis risk, but the relationship to clinical outcome in at-risk individuals is unknown…”
Get full text

Modulation of motivational salience processing during the early stages of psychosis by Smieskova, Renata, Roiser, Jonathan P, Chaddock, Christopher A, Schmidt, André, Harrisberger, Fabienne, Bendfeldt, Kerstin, Simon, Andor, Walter, Anna, Fusar-Poli, Paolo, McGuire, Philip K, Lang, Undine E, Riecher-Rössler, Anita, Borgwardt, Stefan

“…Abstract Background Deficits in motivational salience processing have been related to psychotic symptoms and disturbances in dopaminergic neurotransmission. We…”
Get full text

Genome-wide discovered psychosis-risk gene ZNF804A impacts on white matter microstructure in health, schizophrenia and bipolar disorder by Mallas, Emma-Jane, Carletti, Francesco, Chaddock, Christopher A, Woolley, James, Picchioni, Marco M, Shergill, Sukhwinder S, Kane, Fergus, Allin, Matthew P G, Barker, Gareth J, Prata, Diana P

“…Background. Schizophrenia (SZ) and bipolar disorder (BD) have both been associated with reduced microstructural white matter integrity using, as a proxy,…”
Get full text

Resting Hyperperfusion of the Hippocampus, Midbrain, and Basal Ganglia in People at High Risk for Psychosis by Allen, Paul, Chaddock, Christopher A., Egerton, Alice, Howes, Oliver D., Bonoldi, Ilaria, Zelaya, Fernando, Bhattacharyya, Sagnik, Murray, Robin, McGuire, Philip

“…Objective:Animal models suggest that the development of psychosis involves hyperactivity in the hippocampus that drives increased activity in the midbrain and…”
Get full text

Adversity in childhood linked to elevated striatal dopamine function in adulthood by Egerton, Alice, Valmaggia, Lucia R, Howes, Oliver D, Day, Fern, Chaddock, Christopher A, Allen, Paul, Winton-Brown, Toby T, Bloomfield, Michael A.P, Bhattacharyya, Sagnik, Chilcott, Jack, Lappin, Julia M, Murray, Robin M, McGuire, Philip

“…Abstract Childhood adversity increases the risk of psychosis in adulthood. Theoretical and animal models suggest that this effect may be mediated by increased…”
Get full text

White matter microstructural impairments and genetic liability to familial bipolar I disorder by Chaddock, Christopher A., Barker, Gareth J., Marshall, Nicolette, Schulze, Katja, Hall, Mei Hua, Fern, Adele, Walshe, Muriel, Bramon, Elvira, Chitnis, Xavier A., Murray, Robin, McDonald, Colm

“…Subtle abnormalities in frontal white matter have been reported in bipolar disorder. To assess whether impaired integrity of white matter tracts is associated…”
Get full text

The effect of psychosis associated CACNA1C, and its epistasis with ZNF804A, on brain function by Tecelão, Diogo, Mendes, Ana, Martins, Daniel, Fu, Cynthia, Chaddock, Christopher A., Picchioni, Marco M., McDonald, Colm, Kalidindi, Sridevi, Murray, Robin, Prata, Diana P.

“…CACNA1C‐rs1006737 and ZNF804A‐rs1344706 polymorphisms are among the most robustly associated with schizophrenia (SCZ) and bipolar disorder (BD), and recently…”
Get full text

Functional outcome in people at high risk for psychosis predicted by thalamic glutamate levels and prefronto-striatal activation by Allen, Paul, Chaddock, Christopher A, Egerton, Alice, Howes, Oliver D, Barker, Gareth, Bonoldi, Ilaria, Fusar-Poli, Paolo, Murray, Robin, McGuire, Philip

“…Little is known about the neurobiological factors that determine functional outcome in people at high risk for psychosis. We use multimodal neuroimaging to…”
Get full text

Abnormal relationship between medial temporal lobe and subcortical dopamine function in people with an ultra high risk for psychosis by Allen, Paul, Chaddock, Christopher A, Howes, Oliver D, Egerton, Alice, Seal, Marc L, Fusar-Poli, Paolo, Valli, Isabel, Day, Fern, McGuire, Philip K

“…Neuroimaging studies in humans have implicated both dysfunction of the medial temporal lobe (MTL) and the dopamine system in psychosis, but the relationship…”
Get full text

Neuroanatomy in adolescents and young adults with 22q11 Deletion Syndrome: Comparison to an IQ-matched group by Baker, Kate, Chaddock, Christopher A., Baldeweg, Torsten, Skuse, David

“…22q11 deletion syndrome (22q11DS) is a common genetic condition associated with learning disability and high risk for psychiatric illness, in particular…”
Get full text

Effects of risk for bipolar disorder on brain function: A twin and family study by Sugihara, Genichi, Kane, Fergus, Picchioni, Marco M, Chaddock, Christopher A, Kravariti, Eugenia, Kalidindi, Sridevi, Rijsdijk, Fruhling, Toulopoulou, Timothea, Curtis, Vivienne A, McDonald, Colm, Murray, Robin M, McGuire, Philip

“…Abstract Bipolar disorder (BPD) is associated with altered regional brain function during the performance of cognitive tasks. The relative contribution of…”
Get full text

Poster #S48 THE REPRODUCIBILITY OF 1H-MRS GLUTAMATE CONCENTRATION ESTIMATES AT 3 TESLA, IMPLICATIONS FOR GLUTAMATE IMAGING IN SCHIZOPHRENIA by Merritt, Kate, Stone, James, Barker, Gareth J, Chaddock, Christopher A, McGuire, Philip, Egerton, Alice

Get full text

Interaction between effects of genes coding for dopamine and glutamate transmission on striatal and parahippocampal function by Pauli, Andreina, Prata, Diana P., Mechelli, Andrea, Picchioni, Marco, Fu, Cynthia H.Y., Chaddock, Christopher A., Kane, Fergus, Kalidindi, Sridevi, McDonald, Colm, Kravariti, Eugenia, Toulopoulou, Timothea, Bramon, Elvira, Walshe, Muriel, Ehlert, Natascha, Georgiades, Anna, Murray, Robin, Collier, David A., McGuire, Philip

“…The genes for the dopamine transporter (DAT) and the D‐Amino acid oxidase activator (DAOA or G72) have been independently implicated in the risk for…”
Get full text

RELATIONSHIP BETWEEN BRAIN GLUTAMATE CONCENTRATIONS AND FUNCTIONAL OUTCOME IN INDIVIDUALS AT ULTRA HIGH RISK OF PSYCHOSIS PSYCHOSIS by Egerton, Alice, Stone, James, Chaddock, Christopher A, Barker, Gareth J, Bonoldi, Ilaria, Merritt, Kate, Allen, Paul, Lythgoe, David J, O'Gorman, Ruth L, McGuire, Philip

Get full text

COMT gene polymorphism and corpus callosum morphometry in preterm born adults by Dutt, Anirban, Shaikh, Madiha, Ganguly, Taposhri, Nosarti, Chiara, Walshe, Muriel, Arranz, Maria, Rifkin, Larry, McDonald, Colm, Chaddock, Christopher A, McGuire, Philip, Murray, Robin M, Bramon, Elvira, Allin, Matthew P.G.

“…Preterm birth is associated with a range of neurodevelopmental deficits, including corpus callosum (CC) abnormalities, which persist into late adolescence and…”
Get full text

White matter microstructural impairments and genetic liabilityto familial bipolar I disorder by Chaddock, Christopher A, Barker, Gareth J, Marshall, Nicolette, Schulze, Katja, Hall, Mei Hua, Fern, Adele, Walshe, Muriel, Bramon, Elvira, Chitnis, Xavier A, Murray, Robin, McDonald, Colm

“…BackgroundSubtle abnormalities in frontal white matter have been reported inbipolar disorder.AimsTo assess whether impaired integrity of white matter tracts is…”
Get full text

14:00 ABERRANT PREDICTION ERROR SIGNALLING, SALIENCE ATTRIBUTION AND PRESYNAPTIC DOPAMINE SYNTHESIS IN THE PRODROME OF PSYCHOSIS by Chaddock, Christopher A, Roiser, lonathan P, Howes, Oliver D, McGuire, Philip K

Get full text