Search Results - "Chadderton, N."

MYC/BCL6 DOUBLE HIT LYMPHOMA NEGATIVE FOR T(3;8) BCL6::MYC FUSION IS ASSOCIATED WITH INFERIOR SURVIVAL, IN CONTRAST WITH T(3;8) POSITIVE PSEUDO‐DOUBLE HIT LYMPHOMA by Maybury, B. D., James, L., Chadderton, N., Dowds, J., Venkatadasari, I., Riley, J., Qureshi, I., Talbot, G., Giles, H. V., Phillips, N. J., Gonzalez, M. Vega, Rakesh, P., Haslam, A., Davies, D., Moosai, S., Lane, S. A., Shenouda, A., Cherian, G. V., Kaudlay, P. K., Starczynski, J., Rudzki, Z., Chaganti, S.

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Gene-based therapies for dominantly inherited retinopathies by Farrar, G J, Millington-Ward, S, Chadderton, N, Humphries, P, Kenna, P F

“…In light of the elucidation of the molecular pathogenesis of some dominantly inherited retinal degenerations over the past two decades, it is timely to explore…”
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Interaction of platelet factor 4 with fibroblast growth factor 2 is stabilised by heparan sulphate by Chadderton, Naomi S, Stringer, Sally E

“…The CXC chemokine platelet factor 4 (PF4) appears to inhibit tumour growth through its modulation of the activity of angiogenic growth factors. We investigated…”
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CHD5 Is Required for Neurogenesis and Has a Dual Role in Facilitating Gene Expression and Polycomb Gene Repression by Egan, Chris M., Nyman, Ulrika, Skotte, Julie, Streubel, Gundula, Turner, Siobhán, O’Connell, David J., Rraklli, Vilma, Dolan, Michael J., Chadderton, Naomi, Hansen, Klaus, Farrar, Gwyneth Jane, Helin, Kristian, Holmberg, Johan, Bracken, Adrian P.

“…The chromatin remodeler CHD5 is expressed in neural tissue and is frequently deleted in aggressive neuroblastoma. Very little is known about the function of…”
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RNA Interference–Mediated Suppression and Replacement of Human Rhodopsin In Vivo by O’Reilly, Mary, Palfi, Arpad, Chadderton, Naomi, Millington-Ward, Sophia, Ader, Marius, Cronin, Thérèse, Tuohy, Thérèse, Auricchio, Alberto, Hildinger, Markus, Tivnan, Amanda, McNally, Niamh, Humphries, Marian M., Kiang, Anna-Sophia, Humphries, Pete, Kenna, Paul F., Farrar, G. Jane

“…Mutational heterogeneity represents a significant barrier to development of therapies for many dominantly inherited diseases. For example, >100 mutations in…”
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Adeno-associated virus-mediated rhodopsin replacement provides therapeutic benefit in mice with a targeted disruption of the rhodopsin gene by Palfi, Arpad, Millington-Ward, Sophia, Chadderton, Naomi, O'Reilly, Mary, Goldmann, Tobias, Humphries, Marian M, Li, Tiansen, Wolfrum, Uwe, Humphries, Peter, Kenna, Paul F, Farrar, G Jane

“…The rhodopsin gene (RHO) encodes a highly expressed G protein-coupled receptor that is central to visual transduction in rod photoreceptors. A suite of…”
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Efficacy of codelivery of dual AAV2/5 vectors in the murine retina and hippocampus by Palfi, Arpad, Chadderton, Naomi, McKee, Alex G, Blanco Fernandez, Alfonso, Humphries, Peter, Kenna, Paul F, Farrar, G Jane

“…Recombinant adeno-associated virus (AAV) represents an efficient system for neuronal transduction. However, a potential drawback of AAV is its restricted…”
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Gene-based therapies for dominantly inherited retinopathies : Gene Therapy for Eye Diseases by FARRAR, G. J, MILLINGTON-WARD, S, CHADDERTON, N, HUMPHRIES, P, KENNA, P. F

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Dual responsive promoters to target therapeutic gene expression to radiation-resistant hypoxic tumor cells by Chadderton, Naomi, Cowen, Rachel L, Sheppard, Freda C D, Robinson, Suzanne, Greco, Olga, Scott, Simon D, Stratford, Ian J, Patterson, Adam V, Williams, Kaye J

“…Tumor hypoxia is unequivocally linked to poor radiotherapy outcome. This study aimed to identify enhancer sequences that respond maximally to a combination of…”
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