Search Results - "Chacun, Helene"

Long-circulating PEGylated polycyanoacrylate nanoparticles as new drug carrier for brain delivery by CALVO, Pilar, GOURITIN, Bruno, CHACUN, Hélène, DESMAËLE, Didier, D'ANGELO, Jean, NOEL, Jean-Pierre, GEORGIN, Dominique, FATTAL, Elias, ANDREUX, Jean P, COUVREUR, Patrick

“…The aim of this study was to evaluate the ability of long-circulating PEGylated cyanoacrylate nanoparticles to diffuse into the brain tissue. Biodistribution…”
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Squalenoylation Favorably Modifies the in Vivo Pharmacokinetics and Biodistribution of Gemcitabine in Mice by Reddy, L Harivardhan, Khoury, Hania, Paci, Angelo, Deroussent, Alain, Ferreira, Humberto, Dubernet, Catherine, Declèves, Xavier, Besnard, Madeleine, Chacun, Helène, Lepêtre-Mouelhi, Sinda, Desmaële, Didier, Rousseau, Bernard, Laugier, Christelle, Cintrat, Jean-Christophe, Vassal, Gilles, Couvreur, Patrick

“…Gemcitabine (2′,2′-difluorodeoxyribofuranosylcytosine; dFdC) is an anticancer nucleoside analog active against wide variety of solid tumors. However, this…”
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Role of two efflux proteins, ABCB1 and ABCG2 in blood-brain barrier transport of bromocriptine in a murine model of MPTP-induced dopaminergic degeneration by Vautier, Sarah, Milane, Aline, Fernandez, Christine, Chacun, Helene, Lacomblez, Lucette, Farinotti, Robert

“…MPTP-induced dopaminergic degeneration is an experimental model commonly used to explore Parkinson's disease. Cerebral drug transport by ABC transporters in…”
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Ultrasound-induced mild hyperthermia improves the anticancer efficacy of both Taxol® and paclitaxel-loaded nanocapsules by Boissenot, Tanguy, Bordat, Alexandre, Larrat, Benoît, Varna, Mariana, Chacun, Hélène, Paci, Angelo, Poinsignon, Vianney, Fattal, Elias, Tsapis, Nicolas

“…We study the influence of ultrasound on paclitaxel-loaded nanocapsules in vitro and in vivo. These nanocapsules possess a shell of…”
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PLA-PEG Nanoparticles Improve the Anti-Inflammatory Effect of Rosiglitazone on Macrophages by Enhancing Drug Uptake Compared to Free Rosiglitazone by Giacalone, Giovanna, Tsapis, Nicolas, Mousnier, Ludivine, Chacun, Hélène, Fattal, Elias

“…Among cardiovascular diseases, atherosclerosis remains the first cause of death in the United States of America and Europe, as it leads to myocardial…”
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Squalenoyl adenosine nanoparticles provide neuroprotection after stroke and spinal cord injury by Gaudin, Alice, Yemisci, Müge, Eroglu, Hakan, Lepetre-Mouelhi, Sinda, Turkoglu, Omer Faruk, Dönmez-Demir, Buket, Caban, Seçil, Sargon, Mustafa Fevzi, Garcia-Argote, Sébastien, Pieters, Grégory, Loreau, Olivier, Rousseau, Bernard, Tagit, Oya, Hildebrandt, Niko, Le Dantec, Yannick, Mougin, Julie, Valetti, Sabrina, Chacun, Hélène, Nicolas, Valérie, Desmaële, Didier, Andrieux, Karine, Capan, Yilmaz, Dalkara, Turgay, Couvreur, Patrick

“…There is an urgent need to develop new therapeutic approaches for the treatment of severe neurological trauma, such as stroke and spinal cord injuries…”
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Intestinal permeation enhancement of docetaxel encapsulated into methyl-β-cyclodextrin/poly(isobutylcyanoacrylate) nanoparticles coated with thiolated chitosan by Mazzaferro, Silvia, Bouchemal, Kawthar, Skanji, Rym, Gueutin, Claire, Chacun, Hélène, Ponchel, Gilles

“…In this study we investigated the potential of mucoadhesive nanoparticles to enhance the intestinal permeability of docetaxel (Dtx). These nanoparticles were…”
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Paclitaxel-loaded PEGylated nanocapsules of perfluorooctyl bromide as theranostic agents by Boissenot, Tanguy, Fattal, Elias, Bordat, Alexandre, Houvenagel, Sophie, Valette, Julien, Chacun, Hélène, Gueutin, Claire, Tsapis, Nicolas

“…[Display omitted] We optimize the encapsulation of paclitaxel (PTX) into nanocapsules made of a shell of poly(lactide-co-glycolide)-polyethylene glycol and a…”
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Stabilization and cellular delivery of chitosan–polyphosphate nanoparticles by incorporation of iron by Giacalone, Giovanna, Hillaireau, Hervé, Capiau, Pauline, Chacun, Hélène, Reynaud, Franceline, Fattal, Elias

“…Chitosan (CS) nanoparticles are typically obtained by complexation with tripolyphosphate (TPP) ions, or more recently using triphosphate group-containing drugs…”
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Altered cerebral vascular volumes and solute transport at the blood–brain barriers of two transgenic mouse models of Alzheimer's disease by Do, Tuan Minh, Alata, Wael, Dodacki, Agnès, Traversy, Marie-Thérèse, Chacun, Hélène, Pradier, Laurent, Scherrmann, Jean-Michel, Farinotti, Robert, Calon, Frédéric, Bourasset, Fanchon

“…We evaluated the integrity and function of the blood–brain barrier in 3xTg-AD mice aged 3–18 months and in APP/PS1 mice aged 8-months to determine the impacts…”
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Targeting of 3'-azido 3'-deoxythymidine (AZT)-loaded poly(isohexylcyanoacrylate) nanospheres to the gastrointestinal mucosa and associated lymphoid tissues by DEMBRI, Assia, MONTISCI, Marie-Jeanne, GANTIER, Jean Charles, CHACUN, Hélène, PONCHEI, Gilles

“…The aim of the studv was to evaluate the capacity of poly(isohexylcyanoacrylate) nanospheres to concentrate 3'-azido 3'-deoxythymidine (AZT) in the intestinal…”
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Translocation of Poly(ethylene glycol-co-hexadecyl)cyanoacrylate Nanoparticles into Rat Brain Endothelial Cells:  Role of Apolipoproteins in Receptor-Mediated Endocytosis by Kim, Hyun R, Andrieux, Karine, Gil, Sophie, Taverna, Myriam, Chacun, Héléne, Desmaële, Didier, Taran, Fréderic, Georgin, Dominique, Couvreur, Patrick

“…Previous in vivo observations in rats have shown that poly(ethylene glycol) polyhexadecylcyanoacrylate (PEG-PHDCA) nanoparticles could translocate into the…”
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Towards an Improved anti-HIV Activity of NRTI via Metal-Organic Frameworks Nanoparticles by Agostoni, Valentina, Chalati, Tamim, Horcajada, Patricia, Willaime, Hervé, Anand, Resmi, Semiramoth, Nicolas, Baati, Tarek, Hall, Shaun, Maurin, Guillaume, Chacun, Hélène, Bouchemal, Kawthar, Martineau, Charlotte, Taulelle, Francis, Couvreur, Patrick, Rogez-Kreuz, Christine, Clayette, Pascal, Monti, Sandra, Serre, Christian, Gref, Ruxandra

“…Nanoscale mesoporous iron carboxylates metal–organic frameworks (nanoMOFs) have recently emerged as promising platforms for drug delivery, showing…”
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Analysis of plasma protein adsorption onto PEGylated nanoparticles by complementary methods: 2-DE, CE and Protein Lab-on-chip® system by Kim, Hyun Ryoung, Andrieux, Karine, Delomenie, Claudine, Chacun, Héléne, Appel, Martine, Desmaële, Didier, Taran, Fréderic, Georgin, Dominique, Couvreur, Patrick, Taverna, Myriam

“…The biodistribution of colloidal carriers after their administration in vivo depends on the adsorption of some plasma proteins and apolipoproteins on their…”
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Pharmacokinetics, biodistribution and metabolism of squalenoyl adenosine nanoparticles in mice using dual radio-labeling and radio-HPLC analysis by Gaudin, Alice, Lepetre-Mouelhi, Sinda, Mougin, Julie, Parrod, Martine, Pieters, Grégory, Garcia-Argote, Sébastien, Loreau, Olivier, Goncalves, Jordan, Chacun, Hélène, Courbebaisse, Yann, Clayette, Pascal, Desmaële, Didier, Rousseau, Bernard, Andrieux, Karine, Couvreur, Patrick

“…Adenosine is a pleiotropic endogenous nucleoside with potential neuroprotective pharmacological activity. However, clinical use of adenosine is hampered by its…”
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Formulation and Pharmacokinetics of Thermosensitive Stealth® Liposomes Encapsulating 5-Fluorouracil by Al Sabbagh, Chantal, Tsapis, Nicolas, Novell, Anthony, Calleja-Gonzalez, Patricia, Escoffre, Jean-Michel, Bouakaz, Ayache, Chacun, Hélène, Denis, Stéphanie, Vergnaud, Juliette, Gueutin, Claire, Fattal, Elias

“…ABSTRACT Purpose We optimize the encapsulation and investigate the pharmacokinetics of 5-Fluorouracil (5-FU) delivered by thermosensitive stealth ® liposomes…”
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Direct evidence of abca1-mediated efflux of cholesterol at the mouse blood–brain barrier by Do, Tuan Minh, Ouellet, Mélissa, Calon, Frédéric, Chimini, Giovanna, Chacun, Hélène, Farinotti, Robert, Bourasset, Fanchon

“…We investigated the expression and function of Abca1 in wild-type C57BL/6, abca1 (+/+), and abca1 (−/−) mice brain capillaries forming the blood–brain barrier…”
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Squalenoyl adenosine nanoparticles provide neuroprotection after stroke and spinal cord injury by Gaudin, Alice, Yemisci, Müge, Eroglu, Hakan, Lepetre-Mouelhi, Sinda, Turkoglu, Omer Faruk, Dönmez-Demir, Buket, Caban, Seçil, Sargon, Mustafa Fevzi, Garcia-Argote, Sébastien, Pieters, Grégory, Loreau, Olivier, Rousseau, Bernard, Tagit, Oya, Hildebrandt, Niko, Le Dantec, Yannick, Mougin, Julie, Valetti, Sabrina, Chacun, Hélène, Nicolas, Valérie, Desmaële, Didier, Andrieux, Karine, Capan, Yilmaz, Dalkara, Turgay, Couvreur, Patrick

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Interactions between riluzole and ABCG2/BCRP transporter by Milane, Aline, Vautier, Sarah, Chacun, Hélène, Meininger, Vincent, Bensimon, Gilbert, Farinotti, Robert, Fernandez, Christine

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative fatal disease. Drugs used in this disease need to cross the blood–brain barrier (BBB). Only riluzole…”
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Oatp1a4 and an L-thyroxine-sensitive transporter mediate the mouse blood-brain barrier transport of amyloid-β peptide by Do, Tuan Minh, Bedussi, Beatrice, Chasseigneaux, Stéphanie, Dodacki, Agnès, Yapo, Cédric, Chacun, Hélène, Scherrmann, Jean-Michel, Farinotti, Robert, Bourasset, Fanchon

“…The influx of amyloid-β peptide (Aβ) across the blood-brain barrier is partly mediated by the receptor for advanced glycation end products (RAGE). But other…”
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