Search Results - "Chackerian, Bryce"

Why HIV virions have low numbers of envelope spikes: implications for vaccine development by Schiller, John, Chackerian, Bryce

“…  [...]by evolving an escape mechanism that relies on ignorance of the virions by the humoral immune system, HPVs have not evolved strategies to evade…”
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PCSK9 vaccines: a promising new strategy for the treatment of hypercholesterolemia? by Chackerian, Bryce, Remaley, Alan T.

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Vaccine strategies for lowering LDL by immunization against proprotein convertase subtilisin/kexin type 9 by Chackerian, Bryce, Remaley, Alan

“…mAbs targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) have the potential to become groundbreaking therapies for the treatment of…”
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Cell-Specific Delivery of Diverse Cargos by Bacteriophage MS2 Virus-like Particles by Ashley, Carlee E, Carnes, Eric C, Phillips, Genevieve K, Durfee, Paul N, Buley, Mekensey D, Lino, Christopher A, Padilla, David P, Phillips, Brandy, Carter, Mark B, Willman, Cheryl L, Brinker, C. Jeffrey, Caldeira, Jerri do Carmo, Chackerian, Bryce, Wharton, Walker, Peabody, David S

“…Virus-like particles (VLPs) of bacteriophage MS2 possess numerous features that make them well-suited for use in targeted delivery of therapeutic and imaging…”
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Factors That Govern the Induction of Long-Lived Antibody Responses by Chackerian, Bryce, Peabody, David S

“…The induction of long-lasting, high-titer antibody responses is critical to the efficacy of many vaccines. The ability to produce durable antibody responses is…”
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Virus-like particle based vaccines for Alzheimer disease by Chackerian, Bryce

“…Vaccines targeting the amyloid-β (Aβ) peptide have promise as immunotherapies for the treatment of Alzheimer disease (AD). Human trials of a first generation…”
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The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers by Ashley, Carlee E., Carnes, Eric C., Phillips, Genevieve K., Padilla, David, Durfee, Paul N., Brown, Page A., Hanna, Tracey N., Liu, Juewen, Phillips, Brandy, Carter, Mark B., Carroll, Nick J., Jiang, Xingmao, Dunphy, Darren R., Willman, Cheryl L., Petsev, Dimiter N., Evans, Deborah G., Parikh, Atul N., Chackerian, Bryce, Wharton, Walker, Peabody, David S., Brinker, C. Jeffrey

“…Encapsulation of drugs within nanocarriers that selectively target malignant cells promises to mitigate side effects of conventional chemotherapy and to enable…”
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An epitope-based malaria vaccine targeting the junctional region of circumsporozoite protein by Jelínková, Lucie, Jhun, Hugo, Eaton, Allison, Petrovsky, Nikolai, Zavala, Fidel, Chackerian, Bryce

“…A malaria vaccine that elicits long-lasting protection and is suitable for use in endemic areas remains urgently needed. Here, we assessed the immunogenicity…”
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A pan-HPV vaccine based on bacteriophage PP7 VLPs displaying broadly cross-neutralizing epitopes from the HPV minor capsid protein, L2 by Tumban, Ebenezer, Peabody, Julianne, Peabody, David S, Chackerian, Bryce

“…Current human papillomavirus (HPV) vaccines that are based on virus-like particles (VLPs) of the major capsid protein L1 largely elicit HPV type-specific…”
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VLPs displaying a single L2 epitope induce broadly cross-neutralizing antibodies against human papillomavirus by Tumban, Ebenezer, Peabody, Julianne, Tyler, Mitchell, Peabody, David S, Chackerian, Bryce

“…Virus-like Particles (VLPs) display can be used to increase the immunogenicity of heterologous antigens. Here, we report the use of a bacteriophage MS2-based…”
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A proof-of-concept study for the design of a VLP-based combinatorial HPV and placental malaria vaccine by Janitzek, Christoph M., Peabody, Julianne, Thrane, Susan, H. R. Carlsen, Philip, G. Theander, Thor, Salanti, Ali, Chackerian, Bryce, A. Nielsen, Morten, Sander, Adam F.

“…In Africa, cervical cancer and placental malaria (PM) are a major public health concern. There is currently no available PM vaccine and the marketed Human…”
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RNA Phage VLP-Based Vaccine Platforms by Peabody, David S, Peabody, Julianne, Bradfute, Steven B, Chackerian, Bryce

“…Virus-like particles from a variety of RNA bacteriophages have turned out to be useful platforms for delivery of vaccine antigens in a highly immunogenic…”
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Applying lessons from human papillomavirus vaccines to the development of vaccines against Chlamydia trachomatis by Frietze, Kathryn M, Lijek, Rebeccah, Chackerian, Bryce

“…Chlamydia trachomatis (Ct), the most common bacterial sexually transmitted infection (STI), leads to pelvic inflammatory disease, infertility, and ectopic…”
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Pathogen-specific deep sequence-coupled biopanning: A method for surveying human antibody responses by Frietze, Kathryn M, Pascale, Juan M, Moreno, Brechla, Chackerian, Bryce, Peabody, David S

“…Identifying the targets of antibody responses during infection is important for designing vaccines, developing diagnostic and prognostic tools, and…”
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A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model by Jelínková, Lucie, Flores-Garcia, Yevel, Shapiro, Sarah, Roberts, Bryce T., Petrovsky, Nikolai, Zavala, Fidel, Chackerian, Bryce

“…Pre-erythrocytic malaria vaccines that induce high-titer, durable antibody responses can potentially provide protection from infection. Here, we engineered a…”
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Epitope-Specific Anti-hCG Vaccines on a Virus Like Particle Platform by Caldeira, Jerri, Bustos, Jeremiah, Peabody, Julianne, Chackerian, Bryce, Peabody, David S

“…The possibility of a contraceptive vaccine targeting human chorionic gonadotropin has long been recognized, but never fully realized. Here we describe an…”
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Evaluation of the thermal stability and the protective efficacy of spray-dried HPV vaccine, Gardasil® 9 by Kunda, Nitesh K., Peabody, Julianne, Zhai, Lukai, Price, Dominique N., Chackerian, Bryce, Tumban, Ebenezer, Muttil, Pavan

“…High-risk human papillomavirus (HPV) types are responsible for nearly all cases of cervical cancers. Cervarix® and Gardasil® 9 are the current prophylactic…”
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Minimal Determinants for Lifelong Antiviral Antibody Responses in Mice from a Single Exposure to Virus-like Immunogens at Low Doses by Wholey, Wei-Yun, Meyer, Alexander R, Yoda, Sekou-Tidiane, Chackerian, Bryce, Zikherman, Julie, Cheng, Wei

“…The durability of an antibody (Ab) response is highly important for antiviral vaccines. However, due to the complex compositions of natural virions, the…”
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Engineering an Antibody V Gene-Selective Vaccine by Ronsard, Larance, Yousif, Ashraf S, Peabody, Julianne, Okonkwo, Vintus, Devant, Pascal, Mogus, Alemu Tekewe, Barnes, Ralston M, Rohrer, Daniel, Lonberg, Nils, Peabody, David, Chackerian, Bryce, Lingwood, Daniel

“…The ligand-binding surface of the B cell receptor (BCR) is formed by encoded and non-encoded antigen complementarity determining regions (CDRs). Genetically…”
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Identification of an Immunogenic Mimic of a Conserved Epitope on the Plasmodium falciparum Blood Stage Antigen AMA1 Using Virus-Like Particle (VLP) Peptide Display by Crossey, Erin, Frietze, Kathryn, Narum, David L, Peabody, David S, Chackerian, Bryce

“…We have developed a peptide display platform based on VLPs of the RNA bacteriophage MS2 that combines the high immunogenicity of VLP display with affinity…”
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