Search Results - "Chace, Dana"

Effects of Drug Loading on the Antitumor Activity of a Monoclonal Antibody Drug Conjugate by HAMBLETT, Kevin J, SENTER, Peter D, MEYER, Damon L, FRANCISCO, Joseph A, CHACE, Dana F, SUN, Michael M. C, LENOX, Joel, CERVENY, Charles G, KISSLER, Kim M, BERNHARDT, Starr X, KOPCHA, Anastasia K, ZABINSKI, Roger F

“…Purpose: An antibody-drug conjugate consisting of monomethyl auristatin E (MMAE) conjugated to the anti-CD30 monoclonal antibody (mAb) cAC10, with eight drug…”
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Development of potent monoclonal antibody auristatin conjugates for cancer therapy by Senter, Peter D, Doronina, Svetlana O, Toki, Brian E, Torgov, Michael Y, Mendelsohn, Brian A, Cerveny, Charles G, Chace, Dana F, DeBlanc, Ron L, Gearing, R Patrick, Bovee, Tim D, Siegall, Clay B, Francisco, Joseph A, Wahl, Alan F, Meyer, Damon L

“…We describe the in vitro and in vivo properties of monoclonal antibody (mAb)-drug conjugates consisting of the potent synthetic dolastatin 10 analogs…”
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cAC10-vcMMAE, an anti-CD30–monomethyl auristatin E conjugate with potent and selective antitumor activity by Francisco, Joseph A., Cerveny, Charles G., Meyer, Damon L., Mixan, Bruce J., Klussman, Kerry, Chace, Dana F., Rejniak, Starr X., Gordon, Kristine A., DeBlanc, Ron, Toki, Brian E., Law, Che-Leung, Doronina, Svetlana O., Siegall, Clay B., Senter, Peter D., Wahl, Alan F.

“…The chimeric monoclonal antibody cAC10, directed against CD30, induces growth arrest of CD30+ cell lines in vitro and has pronounced antitumor activity in…”
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Efficient Elimination of B-Lineage Lymphomas by Anti-CD20–Auristatin Conjugates by LAW, Che-Leung, CERVENY, Charles G, SENTER, Peter D, WAHL, Alan F, GORDON, Kristine A, KLUSSMAN, Kerry, MIXAN, Bruce J, CHACE, Dana F, MEYER, Damon L, DORONINA, Svetlana O, SIEGALL, Clay B, FRANCISCO, Joseph A

“…The anti-CD20 antibody rituximab is useful in the treatment of certain B-cell malignancies, most notably non-Hodgkin’s lymphoma. Its efficacy has been…”
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The anti-CD30 monoclonal antibody SGN-30 promotes growth arrest and DNA fragmentation in vitro and affects antitumor activity in models of Hodgkin's disease by WAHL, Alan F, KLUSSMAN, Kerry, THOMPSON, Jennifer D, CHEN, Judy H, FRANCISCO, Leigh V, RISDON, Grant, CHACE, Dana F, SIEGALL, Clay B, FRANCISCO, Joseph A

“…The leukocyte activation marker CD30 is highly expressed on the Reed Sternberg cells of Hodgkin's disease (HD). On normal tissues, CD30 has a restricted…”
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Improved Yield and Stability of L49-sFv−β-Lactamase, a Single-Chain Antibody Fusion Protein for Anticancer Prodrug Activation, by Protein Engineering by McDonagh, Charlotte F, Beam, Kevin S, Wu, Gabrielle J. S, Chen, Judy H, Chace, Dana F, Senter, Peter D, Francisco, Joseph A

“…The L49 single-chain Fv fused to β-lactamase (L49-sFv−bL) combined with the prodrug C-Mel is an effective anticancer agent against tumor cells expressing the…”
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Abstract 688: Characterization and circumvention of drug resistance mechanisms in SGN-35-resistant HL and ALCL clonal cell lines by Lewis, Timothy S., Gordon, Kristine, Li, Fu, Weimann, Allana, Bruders, Rebecca, Miyamoto, Jamie, Chace, Dana, Law, Che-Leung

“…Abstract SGN-35 (cAC10-vcMMAE, brentuximab vedotin) is an auristatin antibody-drug conjugate (ADC), which targets CD30, for the treatment of relapsed Hodgkin…”
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HER4 Expression Correlates with Cytotoxicity Directed by a Heregulin-Toxin Fusion Protein (∗) by Bacus, Sarah S., Chin, Dot M., Goetze, Andy, Siegall, Clay B., Cohen, Bruce D., Plowman, Gregory D., Mixan, Bruce, Chace, Dana, Green, Janell M., Hellström, Ingegerd, Hellström, Karl Erik, Fell, H. Perry

“…We have constructed, expressed, and purified a fusion protein, HAR-TX β2, consisting of heregulin-β2 fused to a binding-defective form of Pseudomonas exotoxin…”
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In vivo activities of acidic fibroblast growth factor-Pseudomonas exotoxin fusion proteins by Siegall, Clay B, Gawlak, Susan L, Chace, Dana F, Merwin, June R, Pastan, Ira

“…Fibroblast growth factor receptors are highly expressed in a variety of cancer cells and activated vasculature. Using chimeric toxins targeted to cell-surface…”
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Agonistic properties and in vivo antitumor activity of the anti-CD40 antibody SGN-14 by FRANCISCO, J. A, DONALDSON, K. L, CHACE, D, SIEGALL, C. B, WAHL, A. F

“…Ligation of CD40 is essential for primary B-cell activation and expansion and yet has suppressive or apoptotic effects on some CD40-expressing neoplasia…”
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Erratum: Development of potent monoclonal antibody auristatin conjugates for cancer therapy by Doronina, Svetlana O, Toki, Brian E, Torgov, Michael Y, Mendelsohn, Brian A, Cerveny, Charles G, Chace, Dana F, DeBlanc, Ron L, Gearing, R Patrick, Bovee, Tim D, Siegall, Clay B, Francisco, Joseph A, Wahl, Alan F, Meyer, Damon L, Senter, Peter D

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Characterization of vascular leak syndrome induced by the toxin component of Pseudomonas exotoxin-based immunotoxins and its potential inhibition with nonsteroidal anti-inflammatory drugs by SIEGALL, C. B, LIGGITT, D, CHACE, D, MIXAN, B, SUGAI, J, DAVIDSON, T, STEINITZ, M

“…Clinical trials of immunotoxins in cancer patients have been limited in many cases by vascular leak syndrome (VLS). Recently, rats were identified as a model…”
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Expression and Characterization of Bryodin 1 and a Bryodin 1-Based Single-Chain Immunotoxin from Tobacco Cell Culture by Francisco, Joseph A, Gawlak, Susan L, Miller, Michael, Bathe, Jessie, Russell, David, Chace, Dana, Mixan, Bruce, Zhao, Lei, Fell, H. Perry, Siegall, Clay B

“…Bryodin 1 (BD1) is a potent ribosome-inactivating protein (RIP) isolated from the plant Bryonia dioica. It is relatively nontoxic in rodents (LD50 > 40 mg/kg)…”
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Development of potent monoclonal antibody auristatin conjugates for cancer therapy by Doronina, Svetlana O, Toki, Brian E, Torgov, Michael Y, Mendelsohn, Brian A, Cerveny, Charles G, Chace, Dana F, DeBlanc, Ron L, Gearing, R Patrick, Bovee, Tim D, Siegall, Clay B, Francisco, Joseph A, Wahl, Alan F, Meyer, Damon L, Senter, Peter D

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Prevention of Immunotoxin-Mediated Vascular Leak Syndrome in Rats with Retention of Antitumor Activity by Siegall, Clay B., Liggitt, Denny, Chace, Dana, Tepper, Mark A., Fell, H. Perry

“…Immunotoxins are hybrid molecules composed of a cell-surface binding domain and a protein toxin moiety that together target specific cell populations for…”
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Prevention of immunotoxin-induced immunogenicity by coadministration with CTLA4Ig enhances antitumor efficacy by Siegall, CB, Haggerty, HG, Warner, GL, Chace, D, Mixan, B, Linsley, PS, Davidson, T

“…Immunotoxins have shown promise as antitumor agents in clinical trials. However, they have not become part of standard cancer therapy because of factors that…”
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In vitro and in vivo characterization of BR96 sFv-PE40. A single-chain immunotoxin fusion protein that cures human breast carcinoma xenografts in athymic mice and rats by Siegall, CB, Chace, D, Mixan, B, Garrigues, U, Wan, H, Paul, L, Wolff, E, Hellstrom, I, Hellstrom, KE

“…BR96 sFv-PE40 is a single-chain immunotoxin fusion protein targeted to the Ley Ag, which is expressed in many different human carcinomas as well as in normal…”
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Antitumor activity of the single-chain immunotoxin BR96 sFv-PE40 against established breast and lung tumor xenografts by Friedman, PN, Chace, DF, Trail, PA, Siegall, CB

“…We have constructed a single-chain immunotoxin consisting of the variable H and L chains of the carcinoma-reactive mAb BR96, fused to the binding defective…”
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BR96 sFv-PE40, a potent single-chain immunotoxin that selectively kills carcinoma cells by FRIEDMAN, P. N, MCANDREW, S. J, GAWLAK, S. L, CHACE, D, TRAIL, P. A, BROWN, J. P, SIEGALL, C. B

“…We have constructed a single-chain immunotoxin composed of the carcinoma-reactive antibody BR96 and a truncated form of Pseudomonas exotoxin. The chimeric…”
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Characterization of Ribosome-Inactivating Proteins Isolated from Bryonia dioica and Their Utility as Carcinoma-Reactive Immunoconjugates by Siegall, Clay B, Gawlak, Susan L, Chace, Dana, Wolff, Edith A, Mixan, Bruce, Marquardt, Hans

“…Two ribosome-inactivating proteins (RIPs) were isolated and characterized from the roots of Bryonia dioica. One of these was a novel 27-kDa protein termed…”
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