Search Results - "Chace, DF"

Effects of Drug Loading on the Antitumor Activity of a Monoclonal Antibody Drug Conjugate by HAMBLETT, Kevin J, SENTER, Peter D, MEYER, Damon L, FRANCISCO, Joseph A, CHACE, Dana F, SUN, Michael M. C, LENOX, Joel, CERVENY, Charles G, KISSLER, Kim M, BERNHARDT, Starr X, KOPCHA, Anastasia K, ZABINSKI, Roger F

“…Purpose: An antibody-drug conjugate consisting of monomethyl auristatin E (MMAE) conjugated to the anti-CD30 monoclonal antibody (mAb) cAC10, with eight drug…”
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cAC10-vcMMAE, an anti-CD30–monomethyl auristatin E conjugate with potent and selective antitumor activity by Francisco, Joseph A., Cerveny, Charles G., Meyer, Damon L., Mixan, Bruce J., Klussman, Kerry, Chace, Dana F., Rejniak, Starr X., Gordon, Kristine A., DeBlanc, Ron, Toki, Brian E., Law, Che-Leung, Doronina, Svetlana O., Siegall, Clay B., Senter, Peter D., Wahl, Alan F.

“…The chimeric monoclonal antibody cAC10, directed against CD30, induces growth arrest of CD30+ cell lines in vitro and has pronounced antitumor activity in…”
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Development of potent monoclonal antibody auristatin conjugates for cancer therapy by Senter, Peter D, Doronina, Svetlana O, Toki, Brian E, Torgov, Michael Y, Mendelsohn, Brian A, Cerveny, Charles G, Chace, Dana F, DeBlanc, Ron L, Gearing, R Patrick, Bovee, Tim D, Siegall, Clay B, Francisco, Joseph A, Wahl, Alan F, Meyer, Damon L

“…We describe the in vitro and in vivo properties of monoclonal antibody (mAb)-drug conjugates consisting of the potent synthetic dolastatin 10 analogs…”
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The anti-CD30 monoclonal antibody SGN-30 promotes growth arrest and DNA fragmentation in vitro and affects antitumor activity in models of Hodgkin's disease by WAHL, Alan F, KLUSSMAN, Kerry, THOMPSON, Jennifer D, CHEN, Judy H, FRANCISCO, Leigh V, RISDON, Grant, CHACE, Dana F, SIEGALL, Clay B, FRANCISCO, Joseph A

“…The leukocyte activation marker CD30 is highly expressed on the Reed Sternberg cells of Hodgkin's disease (HD). On normal tissues, CD30 has a restricted…”
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Efficient Elimination of B-Lineage Lymphomas by Anti-CD20–Auristatin Conjugates by LAW, Che-Leung, CERVENY, Charles G, SENTER, Peter D, WAHL, Alan F, GORDON, Kristine A, KLUSSMAN, Kerry, MIXAN, Bruce J, CHACE, Dana F, MEYER, Damon L, DORONINA, Svetlana O, SIEGALL, Clay B, FRANCISCO, Joseph A

“…The anti-CD20 antibody rituximab is useful in the treatment of certain B-cell malignancies, most notably non-Hodgkin’s lymphoma. Its efficacy has been…”
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Improved Yield and Stability of L49-sFv−β-Lactamase, a Single-Chain Antibody Fusion Protein for Anticancer Prodrug Activation, by Protein Engineering by McDonagh, Charlotte F, Beam, Kevin S, Wu, Gabrielle J. S, Chen, Judy H, Chace, Dana F, Senter, Peter D, Francisco, Joseph A

“…The L49 single-chain Fv fused to β-lactamase (L49-sFv−bL) combined with the prodrug C-Mel is an effective anticancer agent against tumor cells expressing the…”
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Erratum: Development of potent monoclonal antibody auristatin conjugates for cancer therapy by Doronina, Svetlana O, Toki, Brian E, Torgov, Michael Y, Mendelsohn, Brian A, Cerveny, Charles G, Chace, Dana F, DeBlanc, Ron L, Gearing, R Patrick, Bovee, Tim D, Siegall, Clay B, Francisco, Joseph A, Wahl, Alan F, Meyer, Damon L, Senter, Peter D

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Antitumor activity of the single-chain immunotoxin BR96 sFv-PE40 against established breast and lung tumor xenografts by Friedman, PN, Chace, DF, Trail, PA, Siegall, CB

“…We have constructed a single-chain immunotoxin consisting of the variable H and L chains of the carcinoma-reactive mAb BR96, fused to the binding defective…”
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In vivo activities of acidic fibroblast growth factor-Pseudomonas exotoxin fusion proteins by Siegall, Clay B, Gawlak, Susan L, Chace, Dana F, Merwin, June R, Pastan, Ira

“…Fibroblast growth factor receptors are highly expressed in a variety of cancer cells and activated vasculature. Using chimeric toxins targeted to cell-surface…”
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