Search Results - "Chabot, G"

Liposomal encapsulation of the natural flavonoid fisetin improves bioavailability and antitumor efficacy by Seguin, Johanne, Brullé, Laura, Boyer, Renaud, Lu, Yen Mei, Ramos Romano, Miriam, Touil, Yasmine S., Scherman, Daniel, Bessodes, Michel, Mignet, Nathalie, Chabot, Guy G.

“…Liposomal formulation of fisetin improves its bioavailability (A) and antitumor efficacy in mice (B). Lewis lung carcinoma bearing mice treated with empty…”
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Synthesis and in vitro evaluation of potential anticancer activity of mono- and bis-1,2,3-triazole derivatives of bis-alkynes by Elamari, Hichem, Slimi, Riadh, Chabot, Guy G., Quentin, Lionel, Scherman, Daniel, Girard, Christian

“…In order to find new molecules with cytotoxic activity against cancer cells, we prepared bis-akyne amides derived from propiolic acid. The bis-alkynes were…”
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Fisetin disposition and metabolism in mice: Identification of geraldol as an active metabolite by Touil, Yasmine S., Auzeil, Nicolas, Boulinguez, François, Saighi, Hanane, Regazzetti, Anne, Scherman, Daniel, Chabot, Guy G.

“…Although the natural flavonoid fisetin (3,3′,4′,7-tetrahydroxyflavone) has been recently identified as an anticancer agent with antiangiogenic properties in…”
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Activation of Retinoic Acid Receptor-dependent Transcription by All-trans-retinoic Acid Metabolites and Isomers by Idres, Nadia, Marill, Julie, Flexor, Maria A, Chabot, Guy G

“…We have shown that four metabolites of all- trans -retinoic acid (ATRA) (4-oxo-, 4-OH-, 18-OH-, and 5,6-epoxy-RA) can induce maturation of NB4 promyelocytic…”
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Bioavailability of polyphenol liposomes: a challenge ahead by Mignet, Nathalie, Seguin, Johanne, Chabot, Guy G

“…Dietary polyphenols, including flavonoids, have long been recognized as a source of important molecules involved in the prevention of several diseases,…”
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Clinical pharmacokinetics of irinotecan by CHABOT, G. G

“…This article reviews the clinical pharmacokinetics of a water-soluble analogue of camptothecin, irinotecan [CPT-11 or…”
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Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites by Marill, J, Cresteil, T, Lanotte, M, Chabot, G G

“…Cytochrome P450 (P450)-dependent metabolism of all-trans-retinoic acid (atRA) is important for the expression of its biological activity. Because the human…”
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Nivolumab in non-small cell lung cancer: French evaluation of use, current practices and medico-economic approach by Grude, F., Corre, R., Urban, T., Bennouna, J., De Chabot, G., Chatellier, T., Denis, F., Descourt, R., Douillard, J.-Y., Ricordel, C., Molinier, O., Pinquie, F., Robinet, G., Travers, M., Moiteaux, B., Deniel Lagadec, D., Marhuenda, F.

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Possible involvement of programmed cell death pathways in the neuroprotective action of polyphenols by Bastianetto, S, Krantic, S, Chabot, J-G, Quirion, R

“…One of the hallmarks of Alzheimer's disease is the accumulation of senile plaques composed of extra-cellular aggregates of beta-amyloid (Aβ) peptides. It is…”
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Short- and Long-Term Outcome of Patients with Pseudo-Vitamin D Deficiency Rickets Treated with Calcitriol by Edouard, T, Alos, N, Chabot, G, Roughley, P, Glorieux, F. H, Rauch, F

“…Background: Pseudo-vitamin D deficiency rickets (PDDR; OMIM 264700) is a rare autosomal recessive disorder caused by mutations in the CYP27B1 gene, leading to…”
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Cyclic Administration of Pamidronate in Children with Severe Osteogenesis Imperfecta by Glorieux, Francis H, Bishop, Nicholas J, Plotkin, Horacio, Chabot, Gilles, Lanoue, Ginette, Travers, Rose

“…Osteogenesis imperfecta, often referred to as “brittle-bone disease,” is a heritable disorder characterized in most affected persons by either a reduction in…”
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Irinotecan (CPT-11) high-dose escalation using intensive high-dose loperamide to control diarrhea by Abigerges, D, Armand, J P, Chabot, G G, Da Costa, L, Fadel, E, Cote, C, Hérait, P, Gandia, D

“…Diarrhea is a serious side effect that may prevent the administration of high doses of the antitumor drug Irinotecan (CPT-11). Intensive, high-dose loperamide…”
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Synthesis of cytotoxic ferrocenyl flavones via a ferricenium-mediated 1,6-oxidative cyclization by Monserrat, Jean-Philippe, Chabot, Guy G, Hamon, Louis, Quentin, Lionel, Scherman, Daniel, Jaouen, Gérard, Hillard, Elizabeth A

“…The oxidation of the ferrocenyl group of 2'-hydroxyferrocenyl chalcones activates the beta-position of the unsaturated ketone to nucleophilic attack to yield…”
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Lattice coupling and Franck–Condon effects in K-edge resonant inelastic x-ray scattering by Hancock, J N, Chabot-Couture, G, Greven, M

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Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every 3 weeks in cancer patients by Abigerges, D, Chabot, G G, Armand, J P, Hérait, P, Gouyette, A, Gandia, D

“…A phase I study was undertaken to determine the maximum-tolerated dose (MTD), principal toxicities, and pharmacokinetics of the novel topoisomerase I inhibitor…”
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Structure–activity relationships of indole compounds derived from combretastatin A4: Synthesis and biological screening of 5-phenylpyrrolo[3,4- a]carbazole-1,3-diones as potential antivascular agents by Ty, Nancy, Dupeyre, Grégory, Chabot, Guy G., Seguin, Johanne, Quentin, Lionel, Chiaroni, Angèle, Tillequin, François, Scherman, Daniel, Michel, Sylvie, Cachet, Xavier

“…A series of 5-(3′,4′,5′-trimethoxyphenyl)pyrrolo[3,4- a]carbazole-1,3(2 H,10 H)-diones was designed as cis-restricted analogues of 3-aroylindoles,…”
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Importance of dose-schedule of 5-aza-2'-deoxycytidine for epigenetic therapy of cancer by Lemaire, Maryse, Chabot, Guy G, Raynal, Noël Jm, Momparler, Louise F, Hurtubise, Annie, Bernstein, Mark L, Momparler, Richard L

“…The inactivation of tumor suppressor genes (TSGs) by aberrant DNA methylation plays an important role in the development of malignancy. Since this epigenetic…”
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Localization and modulation of calcitonin gene-related peptide-receptor component protein-immunoreactive cells in the rat central and peripheral nervous systems by Ma, W, Chabot, J.-G, Powell, K.J, Jhamandas, K, Dickerson, I.M, Quirion, R

“…Calcitonin gene-related peptide (CGRP) is widely distributed in the central and peripheral nervous system. Its highly diverse biological activities are…”
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In Vivo Electrochemical Detection of Nitric Oxide in Tumor-Bearing Mice by Griveau, Sophie, Dumézy, Charlotte, Séguin, Johanne, Chabot, Guy G, Scherman, Daniel, Bedioui, Fethi

“…Interest in elucidating the mechanisms of action of various classes of anticancer agents and exploring the pathways of the induced-nitric oxide (NO) release…”
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Retinoic acid metabolism and mechanism of action: a review by Marill, Julie, Idres, Nadia, Capron, Claude C, Nguyen, Eric, Chabot, Guy G

“…Retinoids are vitamin A (retinol) derivatives essential for normal embryo development and epithelial differentiation. These compounds are also involved in…”
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