Search Results - "Chabin, R. M"

Substituted 2-aminopyridines as inhibitors of nitric oxide synthases by Hagmann, William K, Caldwell, Charles G, Chen, Ping, Durette, Philippe L, Esser, Craig K, Lanza, Thomas J, Kopka, Ihor E, Guthikonda, Ravi, Shah, Shrenik K, MacCoss, Malcolm, Chabin, Renee M, Fletcher, Daniel, Grant, Stephan K, Green, Barbara G, Humes, John L, Kelly, Theresa M, Luell, Sylvie, Meurer, Roger, Moore, Vernon, Pacholok, Stephen G, Pavia, Tony, Williams, Hollis R, Wong, Kenny K

“…A series of substituted 2-aminopyridines was prepared and evaluated as inhibitors of human nitric oxide synthases (NOS). 4,6-Disubstitution enhanced both…”
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Specificity, stability, and potency of monocyclic β-lactam inhibitors of human leucocyte elastase by KNIGHT, W. B, GREEN, B. G, HAGMANN, W. K, HALE, J. J, LIESCH, J, MACCOSS, M, NAVIA, M. A, SHAH, S. K, UNDERWOOD, D, DOHERTY, J. B, CHABIN, R. M, GALE, P, MAYCOCK, A. L, WESTON, H, KUO, D. W, WESTLER, W. M, DORN, C. P, FINKE, P. E

“…Stable, potent, highly specific, time-dependent monocyclic beta-lactam inhibitors of human leucocyte elastase (HLE) are described. The heavily substituted…”
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Specificity, stability, and potency of monocyclic .beta.-lactam inhibitors of human leukocyte elastase by Knight, W. B, Green, B. G, Chabin, R. M, Gale, P, Maycock, A. L, Weston, H, Kuo, D. W, Westler, W. M, Dorn, C. P

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Association of thiocolchicine with tubulin by Chabin, R M, Hastie, S B

“…Thiocolchicine, a colchicine analog in which the C-10 methoxy is replaced with a thiomethyl moiety, was shown to bind with high affinity to the colchicine site…”
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Inhibitors of the bacterial cell wall biosynthesis enzyme MurD by Gegnas, L D, Waddell, S T, Chabin, R M, Reddy, S, Wong, K K

“…A series of transition-state analog inhibitors of the D-glutamic acid-adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and…”
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Effect of tubulin binding and self-association on the near-ultraviolet circular dichroic spectra of colchicine and analogs by Chabin, Renee M, Feliciano, Francisco, Hastie, Susan Bane

“…Near-UV circular dichroic (CD) spectra of three colchicine analogues that differ at the C-10 position have been obtained in the presence and absence of…”
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Engineering a Cell-Free Murein Biosynthetic Pathway:  Combinatorial Enzymology in Drug Discovery by Wong, Kenny K, Kuo, David W, Chabin, Renee M, Fournier, Carole, Gegnas, Laura D, Waddell, Sherman T, Marsilio, Frank, Leiting, Barbara, Pompliano, David L

“…More than 40 antibiotics in clinical use, mostly beta -lactams and glycopeptides, act by inhibiting the action of penicillin-binding proteins (PBPs) and attest…”
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Active-Site Structure Analysis of Recombinant Human Inducible Nitric Oxide Synthase Using Imidazole by Chabin, Renee M, McCauley, Ermenegilda, Calaycay, Jimmy R, Kelly, Theresa M, MacNaul, Karen L, Wolfe, Gloria C, Hutchinson, Nancy I, Madhusudanaraju, Sayyaparaju, Schmidt, John A, Kozarich, John W, Wong, Kenny K

“…Nitric oxide synthase catalyzes the pyridine nucleotide-dependent oxidation of l-arginine to nitric oxide and l-citrulline. It is a specialized cytochrome P450…”
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Inhibitors of the bacterial cell wall biosynthesis enzyme Mur D by Gegnas, Laura D., Waddell, Sherman T., Chabin, Renee M., Reddy, Sreelatha, Wong, Kenny K.

“…A series of transition-state analog inhibitors of the d-glutamic acid-adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and…”
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Cloning, expression and characterization of the Streptococcus pyogenes murE gene encoding a UDP-MurNAc- l-alanyl- d-glutamate: l-lysine ligase by Triolo, Thomas A, Chabin, Renee M, Pompliano, David L

“…The l-lysine-adding enzyme encoded by the murE gene catalyzes the ATP-dependent formation of UDP-MurNAc- l-alanyl- d-glutamyl- l-lysine…”
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