Search Results - "Chaban, Yuriy"

A conformational switch in response to Chi converts RecBCD from phage destruction to DNA repair by Cheng, Kaiying, Wilkinson, Martin, Chaban, Yuriy, Wigley, Dale B.

“…The RecBCD complex plays key roles in phage DNA degradation, CRISPR array acquisition (adaptation) and host DNA repair. The switch between these roles is…”
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Structure and dynamics of the yeast SWR1-nucleosome complex by Willhoft, Oliver, Ghoneim, Mohamed, Lin, Chia-Liang, Chua, Eugene Y D, Wilkinson, Martin, Chaban, Yuriy, Ayala, Rafael, McCormack, Elizabeth A, Ocloo, Lorraine, Rueda, David S, Wigley, Dale B

“…The yeast SWR1 complex exchanges histone H2A in nucleosomes with Htz1 (H2A.Z in humans). The cryo-electron microscopy structure of the SWR1 complex bound to a…”
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Mechanism for nuclease regulation in RecBCD by Wilkinson, Martin, Chaban, Yuriy, Wigley, Dale B

“…In bacterial cells, processing of double-stranded DNA breaks for repair by homologous recombination is catalysed by AddAB, AdnAB or RecBCD-type…”
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Structural rearrangements in the phage head-to-tail interface during assembly and infection by Chaban, Yuriy, Lurz, Rudi, Brasilès, Sandrine, Cornilleau, Charlène, Karreman, Matthia, Zinn-Justin, Sophie, Tavares, Paulo, Orlova, Elena V.

“…Significance Stable genome maintenance inside viral particles and its controlled delivery to the host are critical for virus infection. We report cryoEM…”
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Interaction of the Mediator Head Module with RNA Polymerase II by Cai, Gang, Chaban, Yuriy L., Imasaki, Tsuyoshi, Kovacs, Julio A., Calero, Guillermo, Penczek, Pawel A., Takagi, Yuichiro, Asturias, Francisco J.

“…Mediator, a large (21 polypeptides, MW ∼1 MDa) complex conserved throughout eukaryotes, plays an essential role in control of gene expression by conveying…”
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Functional characterization and architecture of recombinant yeast SWR1 histone exchange complex by Lin, Chia-Liang, Chaban, Yuriy, Rees, David M, McCormack, Elizabeth A, Ocloo, Lorraine, Wigley, Dale B

“…We have prepared recombinant fourteen subunit yeast SWR1 complex from insect cells using a modified MultiBac system. The 1.07 MDa recombinant protein complex…”
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Structure and nucleosome interaction of the yeast NuA4 and Piccolo-NuA4 histone acetyltransferase complexes by Côté, Jacques, Asturias, Francisco J, Chittuluru, Johnathan R, Chaban, Yuriy, Monnet-Saksouk, Julie, Carrozza, Michael J, Sapountzi, Vasileia, Selleck, William, Huang, Jiehuan, Utley, Rhea T, Cramet, Myriam, Allard, Stephane, Cai, Gang, Workman, Jerry L, Fried, Michael G, Tan, Song

“…NuA4 is an essential and conserved histone acetyltransferase (HAT) complex. Using electron microscopy supported by biochemical analyses, insights are now…”
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Structure of the hDmc1-ssDNA filament reveals the principles of its architecture by Okorokov, Andrei L, Chaban, Yuriy L, Bugreev, Dmitry V, Hodgkinson, Julie, Mazin, Alexander V, Orlova, Elena V

“…In eukaryotes, meiotic recombination is a major source of genetic diversity, but its defects in humans lead to abnormalities such as Down's, Klinefelter's and…”
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Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones by Wilkinson, Martin, Troman, Luca, Wan Nur Ismah, Wan Ak, Chaban, Yuriy, Avison, Matthew B, Dillingham, Mark S, Wigley, Dale B

“…Our previous paper (Wilkinson , 2016) used high-resolution cryo-electron microscopy to solve the structure of the RecBCD complex, which acts in both the repair…”
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Structure and Subunit Arrangement of the A-type ATP Synthase Complex from the Archaeon Methanococcus jannaschii Visualized by Electron Microscopy by Coskun, Ünal, Chaban, Yuriy L., Lingl, Astrid, Müller, Volker, Keegstra, Wilko, Boekema, Egbert J., Grüber, Gerhard

“…In Archaea, bacteria, and eukarya, ATP provides metabolic energy for energy-dependent processes. It is synthesized by enzymes known as A-type or F-type ATP…”
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Structures of mitochondrial oxidative phosphorylation supercomplexes and mechanisms for their stabilisation by Chaban, Yuriy, Boekema, Egbert J., Dudkina, Natalya V.

“…Oxidative phosphorylation (OXPHOS) is the main source of energy in eukaryotic cells. This process is performed by means of electron flow between four enzymes,…”
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Endogenous human NADPH oxidase 2: revealing the insights for a structure-driven drug discovery by Marchese, Sara, Massari, Marta, Basile, Lorenzo, Chaban, Yuriy, Mattevi, Andrea

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IceBreaker: Software for high-resolution single-particle cryo-EM with non-uniform ice by Olek, Mateusz, Cowtan, Kevin, Webb, Donovan, Chaban, Yuriy, Zhang, Peijun

“…Despite the abundance of available software tools, optimal particle selection is still a vital issue in single-particle cryoelectron microscopy (cryo-EM)…”
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Composition of the central stalk of the Na+-pumping V-ATPase from Caloramator fervidus by Chaban, Yuriy, Ubbink-Kok, Trees, Keegstra, Wilko, Lolkema, Juke S, Boekema, Egbert J

“…The Na+‐pumping V‐ATPase complex of the thermophilic bacterium Caloramator fervidus was purified and dissociated under controlled conditions. The structure of…”
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Structural Characterization of an ATPase Active F1-/V1 -ATPase (α3β3EG) Hybrid Complex by Chaban, Yuriy L, Coskun, Unal, Keegstra, Wilko, Oostergetel, Gert T, Boekema, Egbert J, Grüber, Gerhard

“…Co-reconstitution of subunits E and G of the yeast V-ATPase and the α and β subunits of the F 1 -ATPase from the thermophilic Bacillus PS3 (TF 1 ) resulted…”
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Structural insights into the activation of ATM kinase by Xiao, Jianxiong, Liu, Mengjie, Qi, Yilun, Chaban, Yuriy, Gao, Chao, Pan, Beiqing, Tian, Yuan, Yu, Zishuo, Li, Jie, Zhang, Peijun, Xu, Yanhui

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CD44 and CD221 directed magnetic cubosomes for the targeted delivery of helenalin to rhabdomyosarcoma cells by Mun, Hakmin, Chaban, Yuriy, Tabish, Tanveer A., Thorat, Nanasaheb, Cowieson, Nathan, Owen, C. David, Townley, Helen E.

“…Confining chemotherapy to tumour sites by means of active targeting nanoparticles (NPs) may increase the treatment effectuality while reducing potential side…”
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A service-based approach to cryoEM facility processing pipelines at eBIC by Horstmann, Anna, Riggs, Stephen, Chaban, Yuriy, Clare, Daniel K, de Freitas, Guilherme, Farmer, David, Howe, Andrew, Morris, Kyle L, Hatton, Daniel

“…Electron cryo-microscopy image-processing workflows are typically composed of elements that may, broadly speaking, be categorized as high-throughput workloads…”
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Characterization of the rotavirus assembly pathway in situ using cryoelectron tomography by Shah, Pranav N.M., Gilchrist, James B., Forsberg, Björn O., Burt, Alister, Howe, Andrew, Mosalaganti, Shyamal, Wan, William, Radecke, Julika, Chaban, Yuriy, Sutton, Geoff, Stuart, David I., Boyce, Mark

“…Rotavirus assembly is a complex process that involves the stepwise acquisition of protein layers in distinct intracellular locations to form the fully…”
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Structure of a RSC-nucleosome complex and insights into chromatin remodeling by Lorch, Yahli, Chung, Wen-Hsiang, Maier-Davis, Barbara, Kornberg, Roger D, Ezeokonkwo, Chukwudi, Zhang, Fan, Asturias, Francisco J, Chaban, Yuriy

“…The ATP-dependent chromatin-remodeling complexes are involved in repositioning, evicting and restructuring nucleosomes. The EM reconstruction of the RSC…”
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