Search Results - "Cha, Jennifer"

Biophysically Defined and Cytocompatible Covalently Adaptable Networks as Viscoelastic 3D Cell Culture Systems by McKinnon, Daniel D., Domaille, Dylan W., Cha, Jennifer N., Anseth, Kristi S.

“…Presented here is a cytocompatible covalently adaptable hydrogel uniquely capable of mimicking the complex biophysical properties of native tissue and enabling…”
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DNA‐Assembled Core‐Satellite Upconverting‐Metal–Organic Framework Nanoparticle Superstructures for Efficient Photodynamic Therapy by He, Liangcan, Brasino, Michael, Mao, Chenchen, Cho, Suehyun, Park, Wounjhang, Goodwin, Andrew P., Cha, Jennifer N.

“…DNA‐mediated assembly of core–satellite structures composed of Zr(IV)‐based porphyrinic metal‐organic framework (MOF) and NaYF4,Yb,Er upconverting…”
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Nongenetic Bioconjugation Strategies for Modifying Cell Membranes and Membrane Proteins: A Review by Roy, Shambojit, Cha, Jennifer N, Goodwin, Andrew P

“…The cell membrane possesses an extensive library of proteins, carbohydrates, and lipids that control a significant portion of inter- and intracellular…”
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Synthesis and Assembly of Click‐Nucleic‐Acid‐Containing PEG–PLGA Nanoparticles for DNA Delivery by Harguindey, Albert, Domaille, Dylan W., Fairbanks, Benjamin D., Wagner, Justine, Bowman, Christopher N., Cha, Jennifer N.

“…Co‐delivery of both chemotherapy drugs and siRNA from a single delivery vehicle can have a significant impact on cancer therapy due to the potential for…”
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Large-area spatially ordered arrays of gold nanoparticles directed by lithographically confined DNA origami by Cha, Jennifer N, Hung, Albert M, Micheel, Christine M, Bozano, Luisa D, Osterbur, Lucas W, Wallraff, Greg M

“…The development of nanoscale electronic and photonic devices will require a combination of the high throughput of lithographic patterning and the high…”
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Nanoparticle-Mediated Acoustic Cavitation Enables High Intensity Focused Ultrasound Ablation Without Tissue Heating by Yildirim, Adem, Shi, Dennis, Roy, Shambojit, Blum, Nicholas T, Chattaraj, Rajarshi, Cha, Jennifer N, Goodwin, Andrew P

“…While thermal ablation of various solid tumors has been demonstrated using high intensity focused ultrasound (HIFU), the therapeutic outcomes of this technique…”
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Photocrosslinkable, Low-Affinity Affibodies Show Improved Transport and Retention in 3D Tumor Spheroids by Bower, Bryce M., Curry, Shane D., Goodwin, Andrew P., Cha, Jennifer N.

“…The efficacy of affinity-based treatments for cancer and other diseases is often limited by poor distribution throughout the targeted tissue. Although…”
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Bis-Aliphatic Hydrazone-Linked Hydrogels Form Most Rapidly at Physiological pH: Identifying the Origin of Hydrogel Properties with Small Molecule Kinetic Studies by McKinnon, Daniel D, Domaille, Dylan W, Cha, Jennifer N, Anseth, Kristi S

“…Rheological and small molecule kinetic studies were performed to study the formation and hydrolysis of the bis-aliphatic hydrazone bond. The rate of gelation…”
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Enhanced Hydrogen Production from DNA-Assembled Z-Scheme TiO2-CdS Photocatalyst Systems by Ma, Ke, Yehezkeli, Omer, Domaille, Dylan W., Funke, Hans H., Cha, Jennifer N.

“…A wide range of inorganic nanostructures have been used as photocatalysts for generating H2. To increase activity, Z‐scheme photocatalytic systems have been…”
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TiO2‑Capped Gold Nanorods for Plasmon-Enhanced Production of Reactive Oxygen Species and Photothermal Delivery of Chemotherapeutic Agents by He, Liangcan, Mao, Chenchen, Brasino, Michael, Harguindey, Albert, Park, Wounjhang, Goodwin, Andrew P, Cha, Jennifer N

“…Near infrared (NIR)-absorbing noble metal nanostructures are being extensively studied as theranostic agents, in particular for photoacoustic imaging and…”
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Enzyme Prodrug Therapy with Photo-Cross-Linkable Anti-EGFR Affibodies Conjugated to Upconverting Nanoparticles by Roy, Shambojit, Curry, Shane D., Corbella Bagot, Conrad, Mueller, Evan N., Mansouri, Abdulrahman M., Park, Wounjhang, Cha, Jennifer N., Goodwin, Andrew P.

“…In this work, we demonstrate that a photo-cross-linkable conjugate of upconverting nanoparticles and cytosine deaminase can catalyze prodrug conversion…”
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Enzyme Mediated Increase in Methanol Production from Photoelectrochemical Cells and CO2 by Ma, Ke, Yehezkeli, Omer, Park, Eunsol, Cha, Jennifer N

“…While success has been shown in utilizing photocatalytic systems to reduce CO2 in water, most of these studies have yielded formic acid as the major product…”
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Placement and orientation of individual DNA shapes on lithographically patterned surfaces by Rothemund, Paul W. K, Wallraff, Gregory M, Kershner, Ryan J, Bozano, Luisa D, Micheel, Christine M, Hung, Albert M, Fornof, Ann R, Cha, Jennifer N, Rettner, Charles T, Bersani, Marco, Frommer, Jane

“…Artificial DNA nanostructures 1 , 2 show promise for the organization of functional materials 3 , 4 to create nanoelectronic 5 or nano-optical devices. DNA…”
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Anti-EGFR Affibodies with Site-Specific Photo-Cross-Linker Incorporation Show Both Directed Target-Specific Photoconjugation and Increased Retention in Tumors by Brasino, Michael, Roy, Shambojit, Erbse, Annette H, He, Liangcan, Mao, Chenchen, Park, Wounjhang, Cha, Jennifer N, Goodwin, Andrew P

“…A significant challenge for solid tumor treatment is ensuring that a sufficient concentration of therapeutic agent is delivered to the tumor site at doses that…”
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Efficient cellular uptake of click nucleic acid modified proteins by Harguindey, Albert, Culver, Heidi R, Sinha, Jasmine, Bowman, Christopher N, Cha, Jennifer N

“…Efficient intracellular delivery of biomacromolecules such as proteins continues to remain a challenge despite its potential for medicine. In this work, we…”
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Amplified Protein Detection and Identification through DNA-Conjugated M13 Bacteriophage by Lee, Ju Hun, Domaille, Dylan W, Cha, Jennifer N

“…Sensitive protein detection and accurate identification continues to be in great demand for disease screening in clinical and laboratory settings. For these…”
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Effect of covalent photoconjugation of affibodies to epidermal growth factor receptor (EGFR) on cellular quiescence by Roy, Shambojit, Curry, Shane D., Bibbey, Michael G., Chapnick, Douglas A., Liu, Xuedong, Goodwin, Andrew P., Cha, Jennifer N.

“…Cellular quiescence is a reversible state of cell cycle arrest whereby cells are temporarily maintained in the nondividing phase. Inducing quiescence in cancer…”
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DNA‐Assembled Core‐Satellite Upconverting‐Metal–Organic Framework Nanoparticle Superstructures for Efficient Photodynamic Therapy by He, Liangcan, Brasino, Michael, Mao, Chenchen, Cho, Suehyun, Park, Wounjhang, Goodwin, Andrew P., Cha, Jennifer N.

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Click Nucleic Acid Mediated Loading of Prodrug Activating Enzymes in PEG–PLGA Nanoparticles for Combination Chemotherapy by Harguindey, Albert, Roy, Shambojit, Harris, Alexander W, Fairbanks, Benjamin D, Goodwin, Andrew P, Bowman, Christopher N, Cha, Jennifer N

“…The simultaneous delivery of multiple therapeutics to a single site has shown promise for cancer targeting and treatment. However, because of the inherent…”
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Creating highly amplified enzyme-linked immunosorbent assay signals from genetically engineered bacteriophage by Brasino, Michael, Lee, Ju Hun, Cha, Jennifer N.

“…For early detection of many diseases, it is critical to be able to diagnose small amounts of biomarkers in blood or serum. One of the most widely used sensing…”
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