Search Results - "Cha, Hyuk‑Jin"

Stochastic and Heterogeneous Cancer Cell Migration: Experiment and Theory by Kwon, Taejin, Kwon, Ok-Seon, Cha, Hyuk-Jin, Sung, Bong June

“…Cell migration, an essential process for normal cell development and cancer metastasis, differs from a simple random walk: the mean-square displacement (〈(Δ r…”
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Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c–SIRT2 axis by Cha, Young, Han, Min-Joon, Cha, Hyuk-Jin, Zoldan, Janet, Burkart, Alison, Jung, Jin Hyuk, Jang, Yongwoo, Kim, Chun-Hyung, Jeong, Ho-Chang, Kim, Byung-Gyu, Langer, Robert, Kahn, C. Ronald, Guarente, Leonard, Kim, Kwang-Soo

“…A hallmark of cancer cells is the metabolic switch from oxidative phosphorylation (OXPHOS) to glycolysis, a phenomenon referred to as the ‘Warburg effect’,…”
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In silico drug repositioning: from large-scale transcriptome data to therapeutics by Kwon, Ok-Seon, Kim, Wankyu, Cha, Hyuk-Jin, Lee, Haeseung

“…Drug repositioning is an attractive alternative to conventional drug development when new beneficial effects of old drugs are clinically validated because…”
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Connectivity map-based drug repositioning of bortezomib to reverse the metastatic effect of GALNT14 in lung cancer by Kwon, Ok-Seon, Lee, Haeseung, Kong, Hyeon-Joon, Kwon, Eun-Ji, Park, Ji Eun, Lee, Wooin, Kang, Seungmin, Kim, Mirang, Kim, Wankyu, Cha, Hyuk-Jin

“…Despite the continual discovery of promising new cancer targets, drug discovery is often hampered by the poor druggability of these targets. As such,…”
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Remodeling of sorafenib as an orally bioavailable ferroptosis inducer for Lung Cancer by chemical modification of adenine-binding motif by Kim, Yun-Jeong, Lim, Bumhee, Kim, Seo Young, Shin, Yoon-Ze, Yu, Nayoung, Shin, Eun-Kyung, Lee, Jae-Eon, Jeon, Yong Hyun, Kim, Dae-Duk, Lee, Jeeyeon, Cha, Hyuk-Jin

“…Sorafenib (BAY 43–9006) was developed as a multi-kinase inhibitor to treat advanced renal cell, hepatocellular, and thyroid cancers. The cytotoxic effect of…”
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Enhancing genome editing in hPSCs through dual inhibition of DNA damage response and repair pathways by Park, Ju-Chan, Kim, Yun-Jeong, Hwang, Gue-Ho, Kang, Chan Young, Bae, Sangsu, Cha, Hyuk-Jin

“…Precise genome editing is crucial for establishing isogenic human disease models and ex vivo stem cell therapy from the patient-derived hPSCs. Unlike…”
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Inhibition of pluripotent stem cell-derived teratoma formation by small molecules by Lee, Mi-Ok, Moon, Sung Hwan, Jeong, Ho-Chang, Yi, Ji-Yeon, Lee, Tae-Hee, Shim, Sung Han, Rhee, Yong-Hee, Lee, Sang-Hun, Oh, Seok-Jeong, Lee, Moo-Yeol, Han, Min-Joon, Cho, Yee Sook, Chung, Hyung-Min, Kim, Kwang-Soo, Cha, Hyuk-Jin

“…The future of safe cell-based therapy rests on overcoming teratoma/tumor formation, in particular when using human pluripotent stem cells (hPSCs), such as…”
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Optimizing tissue-clearing conditions based on analysis of the critical factors affecting tissue-clearing procedures by Kim, June Hoan, Jang, Min Jee, Choi, Jungyoon, Lee, Eunsoo, Song, Kyung–Deok, Cho, Jaeho, Kim, Keun-Tae, Cha, Hyuk-Jin, Sun, Woong

“…Tissue-clearing techniques have received great attention for volume imaging and for the potential to be applied in optical diagnosis. In principle, tissue…”
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A Theoretical Model for the Cell Cycle and Drug Induced Cell Cycle Arrest of FUCCI Systems with Cell-to-Cell Variation during Mitosis by Bae, Hyeonjeong, Go, Young-Hyun, Kwon, Taejin, Sung, Bong June, Cha, Hyuk-Jin

“…Purpose Since the molecular mechanism of the cell cycle was established, various theoretical models of this process have been developed. A recent study…”
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Crosstalk between YAP and TGFβ regulates SERPINE1 expression in mesenchymal lung cancer cells by Kong, Hyeon‑Joon, Kwon, Eun‑Ji, Kwon, Ok‑Seon, Lee, Haeseung, Choi, Jeong‑Yun, Kim, Yung‑Jeong, Kim, Wankyu, Cha, Hyuk‑Jin

“…Serpin family E member 1 (SERPINE1), a serine proteinase inhibitor, serves as an important regulator of extra-cellular matrix remodeling. Emerging evidence…”
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TGFβ promotes YAP‐dependent AXL induction in mesenchymal‐type lung cancer cells by Choi, Jeong‐Yun, Lee, Haeseung, Kwon, Eun‐Ji, Kong, Hyeon‐Joon, Kwon, Ok‐Seon, Cha, Hyuk‐Jin

“…Through integration of multiple large database, two oncogenic signatures (YAP conserved and TGFβ‐up signatures) were commonly upregulated in the cancer cell…”
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Loss of E-cadherin activates EGFR-MEK/ERK signaling, which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer by Bae, Gab-Yong, Choi, So-Jung, Lee, Ji-Seon, Jo, Jisuk, Lee, Jinseon, Kim, Jhingook, Cha, Hyuk-Jin

“…Loss of E-cadherin, a hallmark of epithelial-mesenchymal transition (EMT), can significantly affect metastatic dissemination. However, the molecular mechanism…”
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Technical approaches to induce selective cell death of pluripotent stem cells by Jeong, Ho-Chang, Cho, Seung-Ju, Lee, Mi-Ok, Cha, Hyuk-Jin

“…Despite the recent promising results of clinical trials using human pluripotent stem cell (hPSC)-based cell therapies for age-related macular degeneration…”
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PRMT8 Controls the Pluripotency and Mesodermal Fate of Human Embryonic Stem Cells By Enhancing the PI3K/AKT/SOX2 Axis by Jeong, Ho‐Chang, Park, Soon‐Jung, Choi, Jong‐Jin, Go, Young‐Hyun, Hong, Soon‐Ki, Kwon, Ok‐Seon, Shin, Joong‐Gon, Kim, Rae‐Kwon, Lee, Mi‐Ok, Lee, Su‐Jae, Shin, Hyoung Doo, Moon, Sung‐Hwan, Cha, Hyuk‐Jin

“…Basic fibroblast growth factor (bFGF) supplementation is critical to maintain the pluripotency of human pluripotent stem cells (hPSCs) through activation of…”
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Large-scale pharmacogenomics based drug discovery for ITGB3 dependent chemoresistance in mesenchymal lung cancer by Hong, Soon-Ki, Lee, Haeseung, Kwon, Ok-Seon, Song, Na-Young, Lee, Hyo-Ju, Kang, Seungmin, Kim, Jeong-Hwan, Kim, Mirang, Kim, Wankyu, Cha, Hyuk-Jin

“…Even when targets responsible for chemoresistance are identified, drug development is often hampered due to the poor druggability of these proteins. We…”
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BCL2 induced by LAMTOR3/MAPK is a druggable target of chemoradioresistance in mesenchymal lung cancer by Kwon, Ok-Seon, Hong, Soon-Ki, Kwon, Soo-Jung, Go, Young-Hyun, Oh, Ensel, Cha, Hyuk-Jin

“…Abstract Mesenchymal-type cancers after epithelial mesenchymal transition (EMT) were recently shown to acquire chemoresistance through expressing EMT specific…”
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Systematic omics analysis identifies CCR6 as a therapeutic target to overcome cancer resistance to EGFR inhibitors by Kwon, Eun-Ji, Cha, Hyuk-Jin, Lee, Haeseung

“…Epidermal growth factor receptor inhibitors (EGFRi) have exhibited promising clinical outcomes in the treatment of various cancers. However, their widespread…”
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Gene editing with 'pencil' rather than 'scissors' in human pluripotent stem cells by Park, Ju-Chan, Park, Mihn Jeong, Lee, Seung-Yeon, Kim, Dayeon, Kim, Keun-Tae, Jang, Hyeon-Ki, Cha, Hyuk-Jin

“…Owing to the advances in genome editing technologies, research on human pluripotent stem cells (hPSCs) have recently undergone breakthroughs that enable…”
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TPX2 prompts mitotic survival via the induction of BCL2L1 through YAP1 protein stabilization in human embryonic stem cells by Kim, Yun-Jeong, Go, Young-Hyun, Jeong, Ho-Chang, Kwon, Eun-Ji, Kim, Seong-Min, Cheong, Hyun Sub, Kim, Wantae, Shin, Hyoung Doo, Lee, Haeseung, Cha, Hyuk-Jin

“…Genetic alterations have been reported for decades in most human embryonic stem cells (hESCs). Survival advantage, a typical trait acquired during long-term in…”
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Senescent Growth Arrest in Mesenchymal Stem Cells Is Bypassed by Wip1‐Mediated Downregulation of Intrinsic Stress Signaling Pathways by Lee, Ji‐Seon, Lee, Mi‐Ok, Moon, Bo‐Hyun, Shim, Sung Han, Fornace, Albert J., Cha, Hyuk‐Jin

“…Human mesenchymal stem cells (hMSCs) have been widely studied as a source of primary adult stem cells for cell therapy because of their multidifferentiation…”
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