Search Results - "Cha, Diana"

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles by Guix, Francesc X, Corbett, Grant T, Cha, Diana J, Mustapic, Maja, Liu, Wen, Mengel, David, Chen, Zhicheng, Aikawa, Elena, Young-Pearse, Tracy, Kapogiannis, Dimitrios, Selkoe, Dennis J, Walsh, Dominic M

“…Progressive cerebral accumulation of tau aggregates is a defining feature of Alzheimer's disease (AD). A popular theory that seeks to explain the apparent…”
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KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes by McKenzie, Andrew J., Hoshino, Daisuke, Hong, Nan Hyung, Cha, Diana J., Franklin, Jeffrey L., Coffey, Robert J., Patton, James G., Weaver, Alissa M.

“…Secretion of RNAs in extracellular vesicles is a newly recognized form of intercellular communication. A potential regulatory protein for microRNA (miRNA)…”
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miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer's Patients by Cha, Diana J, Mengel, David, Mustapic, Maja, Liu, Wen, Selkoe, Dennis J, Kapogiannis, Dimitrios, Galasko, Douglas, Rissman, Robert A, Bennett, David A, Walsh, Dominic M

“…It was recently discovered that brain cells release extracellular vesicles (EV) which can pass from brain into blood. These findings raise the possibility that…”
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Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes by Dou, Yongchao, Cha, Diana J., Franklin, Jeffrey L., Higginbotham, James N., Jeppesen, Dennis K., Weaver, Alissa M., Prasad, Nripesh, Levy, Shawn, Coffey, Robert J., Patton, James G., Zhang, Bing

“…Recent studies have shown that circular RNAs (circRNAs) are abundant, widely expressed in mammals, and can display cell-type specific expression. However, how…”
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KRAS-dependent sorting of miRNA to exosomes by Cha, Diana J, Franklin, Jeffrey L, Dou, Yongchao, Liu, Qi, Higginbotham, James N, Demory Beckler, Michelle, Weaver, Alissa M, Vickers, Kasey, Prasad, Nirpesh, Levy, Shawn, Zhang, Bing, Coffey, Robert J, Patton, James G

“…Mutant KRAS colorectal cancer (CRC) cells release protein-laden exosomes that can alter the tumor microenvironment. To test whether exosomal RNAs also…”
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Diverse Long RNAs Are Differentially Sorted into Extracellular Vesicles Secreted by Colorectal Cancer Cells by Hinger, Scott A., Cha, Diana J., Franklin, Jeffrey L., Higginbotham, James N., Dou, Yongchao, Ping, Jie, Shu, Lihua, Prasad, Nripesh, Levy, Shawn, Zhang, Bing, Liu, Qi, Weaver, Alissa M., Coffey, Robert J., Patton, James G.

“…The regulation and functional roles of secreted coding and long noncoding RNAs (lncRNAs; >200 nt) are largely unknown. We previously showed that mutant KRAS…”
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Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer’s disease by Ellwanger, Daniel C., Wang, Shoutang, Brioschi, Simone, Shao, Zhifei, Green, Lydia, Case, Ryan, Yoo, Daniel, Weishuhn, Dawn, Rathanaswami, Palaniswami, Bradley, Jodi, Rao, Sara, Cha, Diana, Luan, Peng, Sambashivan, Shilpa, Gilfillan, Susan, Hasson, Samuel A., Foltz, Ian N., van Lookeren Campagne, Menno, Colonna, Marco

“…Triggering receptor expressed on myeloid cells 2 (TREM2) sustains microglia response to brain injury stimuli including apoptotic cells, myelin damage, and…”
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miR-153 regulates SNAP-25, synaptic transmission, and neuronal development by Wei, Chunyao, Thatcher, Elizabeth J, Olena, Abigail F, Cha, Diana J, Perdigoto, Ana L, Marshall, Andrew F, Carter, Bruce D, Broadie, Kendal, Patton, James G

“…SNAP-25 is a core component of the trimeric SNARE complex mediating vesicle exocytosis during membrane addition for neuronal growth, neuropeptide/growth factor…”
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RNAi-Mediated Gene silencing in Zebrafish Triggered by Convergent Transcription by Andrews, Omozusi E., Cha, Diana J., Wei, Chunyao, Patton, James G.

“…RNAi based strategies to induce gene silencing are commonly employed in numerous model organisms but have not been extensively used in zebrafish. We found that…”
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Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates by Brown, Kirk M., Nair, Jayaprakash K., Janas, Maja M., Anglero-Rodriguez, Yesseinia I., Dang, Lan T. H., Peng, Haiyan, Theile, Christopher S., Castellanos-Rizaldos, Elena, Brown, Christopher, Foster, Donald, Kurz, Jeffrey, Allen, Jeffrey, Maganti, Rajanikanth, Li, Jing, Matsuda, Shigeo, Stricos, Matthew, Chickering, Tyler, Jung, Michelle, Wassarman, Kelly, Rollins, Jeff, Woods, Lauren, Kelin, Alex, Guenther, Dale C., Mobley, Melissa W., Petrulis, John, McDougall, Robin, Racie, Timothy, Bombardier, Jessica, Cha, Diana, Agarwal, Saket, Johnson, Lei, Jiang, Yongfeng, Lentini, Scott, Gilbert, Jason, Nguyen, Tuyen, Chigas, Samantha, LeBlanc, Sarah, Poreci, Urjana, Kasper, Anne, Rogers, Arlin B., Chong, Saeho, Davis, Wendell, Sutherland, Jessica E., Castoreno, Adam, Milstein, Stuart, Schlegel, Mark K., Zlatev, Ivan, Charisse, Klaus, Keating, Mark, Manoharan, Muthiah, Fitzgerald, Kevin, Wu, Jing-Tao, Maier, Martin A., Jadhav, Vasant

“…Therapeutics based on short interfering RNAs (siRNAs) delivered to hepatocytes have been approved, but new delivery solutions are needed to target additional…”
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An Investigational RNAi Therapeutic for Tau Lowering by Farley, Jonathan, Haines, Jeffery D, Gannon, Sean, Nguyen, Tuyen, Abbott, Stephen, Darcy, Justin, Tymon, Roxanne, Cha, Diana, Schlegel, Mark, Castoreno, Adam, Bisbe, Anna, Zlatev, Ivan, Rollins, Jeff, Bostwick, Bret, Avbersek, Andreja, Macdonald, Lynn, Gao, Min, Anderson, Matthew, Brown, Kirk

“…Background The hyperphosphorylation, mislocalization, and aggregation of the microtubule associated protein Tau (MAPT) is a driving force in tauopathies, a…”
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A community-led approach to COVID-19 by Artelle, Kyle A, Brown, Kelly, Chan, Diana E, Silver, Jennifer J

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KRAS-Dependent Regulation of Extracellular RNAs in Colorectal Cancer by Cha, Diana Jean

“…Mutant KRAS colorectal cancer (CRC) cells release protein-laden exosomes that can alter the tumor microenvironment. To test whether exosomal RNA might also…”
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Analysis of tau in neuron-derived extracellular vesicles by Guix Rafols, Francesc Xavier, Corbett, Grant T, Cha, Diana J, Mustapic, Maja, Liu, Wen, Mengel, David, Chen, Zhicheng, Aikawa, Elena, Young-Pearse, Tracy, Kapogiannis, Dimitrios, Selkoe, Dennis J, Walsh, Dominic M

“…Background: Progressive cerebral accumulation of tau aggregates is a defining feature of Alzheimer's disease (AD). The "pathogenic spread model" proposes that…”
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Relatório Final Estágio Profissionalizante by Vila-Chã, Diana Raquel Passos

“…O estágio profissionalizante do 6º ano do Mestrado Integrado em Medicina (MIM) da Faculdade de Ciências Médicas da Universidade Nova de Lisboa, sob regência do…”
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Necrólisis epidérmica tóxica inducida por lamotrigina. Tratamiento con inmunoglobulina intravenosa by Barquín, María Antonia, Gatti, Carlos Fernándo, Cha, Diana Marta, Rodríguez, Maria Clara

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Updates on gastric electrical stimulation to treat obesity: Systematic review and future perspectives by Cha, Ryan, Marescaux, Jacques, Diana, Michele

“…AIM: To evaluate the current state-of-the-art of gastric electrical stimulation to treat obesity. METHODS: Systematic reviews of all studies have been…”
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