Search Results - "Chételat, Gaël"

Alzheimer disease: Aβ-independent processes-rethinking preclinical AD by Chetelat, Gael

“…The amyloid cascade hypothesis, which posits that amyloid-β accumulation is the key event in Alzheimer disease neurodegeneration, has dominated the field for…”
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Multimodal Neuroimaging in Alzheimer's Disease: Early Diagnosis, Physiopathological Mechanisms, and Impact of Lifestyle by Chételat, Gaël

“…Over the last ten years, we have conducted research in Alzheimer's disease (AD) using multimodal neuroimaging techniques to improve diagnosis, further our…”
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Structural imaging of hippocampal subfields in healthy aging and Alzheimer’s disease by de Flores, Robin, La Joie, Renaud, Chételat, Gaël

“…Highlights • Hippocampal subfield structure can be assessed in vivo with (high-resolution) MRI. • AD-related atrophy is initially focal (in CA1) before…”
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Which is to blame for cognitive decline in ageing: amyloid deposition, neurodegeneration or both? by Gonneaud, Julie, Chételat, Gaël

“…This scientific commentary refers to 'Effects of amyloid pathology and neurodegeneration on cognitive change in cognitively normal adults', by Bilgel et al…”
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White matter hyperintensities in Alzheimer's disease: Beyond (but not instead of) the vascular contribution by Garnier‐Crussard, Antoine, Chételat, Gaël

“…Abstract White matter hyperintensities (WMH), frequently seen in older adults, are usually considered vascular lesions, and participate in the vascular…”
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The Default Mode Network in Healthy Aging and Alzheimer's Disease by Mevel, Katell, Chételat, Gaël, Eustache, Francis, Desgranges, Béatrice

“…In the past decade, a “default mode network” (DMN) has been highlighted in neuroimaging studies as a set of brain regions showing increased activity in…”
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Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease by Villemagne, Victor L., Pike, Kerryn E., Chételat, Gaël, Ellis, Kathryn A., Mulligan, Rachel S., Bourgeat, Pierrick, Ackermann, Uwe, Jones, Gareth, Szoeke, Cassandra, Salvado, Olivier, Martins, Ralph, O'Keefe, Graeme, Mathis, Chester A., Klunk, William E., Ames, David, Masters, Colin L., Rowe, Christopher C.

“…Objective Assess Aβ deposition longitudinally and explore its relationship with cognition and disease progression. Methods Clinical follow‐up was obtained 20 ±…”
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Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging by Kalpouzos, Grégoria, Chételat, Gaël, Baron, Jean-Claude, Landeau, Brigitte, Mevel, Katell, Godeau, Christine, Barré, Louisa, Constans, Jean-Marc, Viader, Fausto, Eustache, Francis, Desgranges, Béatrice

“…Abstract With age, the brain undergoes both structural and functional alterations, probably resulting in reported cognitive declines. Relatively few…”
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White matter hyperintensity topography in Alzheimer's disease and links to cognition by Garnier‐Crussard, Antoine, Bougacha, Salma, Wirth, Miranka, Dautricourt, Sophie, Sherif, Siya, Landeau, Brigitte, Gonneaud, Julie, De Flores, Robin, de la Sayette, Vincent, Vivien, Denis, Krolak‐Salmon, Pierre, Chételat, Gaël

“…Introduction White matter hyperintensities (WMH) are often described in Alzheimer's disease (AD), but their topography and specific relationships with…”
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Morphological brain plasticity induced by musical expertise is accompanied by modulation of functional connectivity at rest by Fauvel, Baptiste, Groussard, Mathilde, Chételat, Gaël, Fouquet, Marine, Landeau, Brigitte, Eustache, Francis, Desgranges, Béatrice, Platel, Hervé

“…The aim of this study was to explore whether musical practice-related gray matter increases in brain regions are accompanied by modifications in their…”
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Distinct influence of specific versus global connectivity on the different Alzheimer's disease biomarkers by Mutlu, Justine, Landeau, Brigitte, Gaubert, Malo, de La Sayette, Vincent, Desgranges, Béatrice, Chételat, Gaël

“…See Franzmeier and Dyrba (doi:10.1093/brain/awx304) for a scientific commentary on this article. Recent findings suggest that the topography and propagation of…”
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Regional dynamics of amyloid-β deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: a voxelwise PiB―PET longitudinal study by VILLAIN, Nicolas, CHETELAT, Gaël, MASTERS, Colin L, ROWE, Christopher C, VILLEMAGNE, Victor L, GRASSIOT, Blandine, BOURGEAT, Pierrick, JONES, Gareth, ELLIS, Kathryn A, AMES, David, MARTINS, Ralph N, EUSTACHE, Francis, SALVADO, Olivier

“…Amyloid-β deposition in Alzheimer's disease is thought to start while individuals are still cognitively unimpaired and it is hypothesized that after an early…”
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Relationships between years of education and gray matter volume, metabolism and functional connectivity in healthy elders by Arenaza-Urquijo, Eider M., Landeau, Brigitte, La Joie, Renaud, Mevel, Katell, Mézenge, Florence, Perrotin, Audrey, Desgranges, Béatrice, Bartrés-Faz, David, Eustache, Francis, Chételat, Gaël

“…More educated elders are less susceptible to age-related or pathological cognitive changes. We aimed at providing a comprehensive contribution to the neural…”
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Suspected non-Alzheimer disease pathophysiology — concept and controversy by Jack, Clifford R., Knopman, David S., Chételat, Gaël, Dickson, Dennis, Fagan, Anne M., Frisoni, Giovanni B., Jagust, William, Mormino, Elizabeth C., Petersen, Ronald C., Sperling, Reisa A., van der Flier, Wiesje M., Villemagne, Victor L., Visser, Pieter J., Vos, Stephanie J. B.

“…Suspected non-Alzheimer disease pathophysiology (SNAP) is a biomarker-based concept that applies to individuals with normal levels of amyloid-β biomarkers in…”
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Relationship between atrophy and β-amyloid deposition in Alzheimer disease by Chételat, Gaël, Villemagne, Victor L., Bourgeat, Pierrick, Pike, Kerryn E., Jones, Gareth, Ames, David, Ellis, Kathryn A., Szoeke, Cassandra, Martins, Ralph N., O'Keefe, Graeme J., Salvado, Olivier, Masters, Colin L., Rowe, Christopher C.

“…Objective Elucidating the role of aggregated β‐amyloid in relation to gray matter atrophy is crucial to the understanding of the pathological mechanisms of…”
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Brain changes associated with sleep disruption in cognitively unimpaired older adults: A short review of neuroimaging studies by André, Claire, Laniepce, Alice, Chételat, Gaël, Rauchs, Géraldine

“…•Sleep disruption is increasingly considered as a risk factor for Alzheimer’s disease.•Poor sleep is associated with diffuse frontal, temporal and parietal…”
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Amyloid imaging in cognitively normal individuals, at-risk populations and preclinical Alzheimer's disease by Chételat, Gaël, La Joie, Renaud, Villain, Nicolas, Perrotin, Audrey, de La Sayette, Vincent, Eustache, Francis, Vandenberghe, Rik

“…Recent developments of PET amyloid ligands have made it possible to visualize the presence of Aβ deposition in the brain of living participants and to assess…”
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Relationships between sleep quality and brain volume, metabolism and amyloid deposition in late adulthood by Branger, Pierre, MD, Arenaza-Urquijo, Eider, PhD, Tomadesso, Clémence, MSc, Mézenge, Florence, BA, André, Claire, MSc, de Flores, Robin, MSc, Mutlu, Justine, MSc, de La Sayette, Vincent, MD, PhD, Eustache, Francis, PhD, Chételat, Gaël, PhD, Rauchs, Géraldine, PhD

“…Abstract Recent studies in mouse models of Alzheimer’s disease (AD) and in humans suggest that sleep disruption and amyloid-beta (Aβ) accumulation are…”
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Multidimensional classification of hippocampal shape features discriminates Alzheimer's disease and mild cognitive impairment from normal aging by Gerardin, Emilie, Chételat, Gaël, Chupin, Marie, Cuingnet, Rémi, Desgranges, Béatrice, Kim, Ho-Sung, Niethammer, Marc, Dubois, Bruno, Lehéricy, Stéphane, Garnero, Line, Eustache, Francis, Colliot, Olivier

“…We describe a new method to automatically discriminate between patients with Alzheimer's disease (AD) or mild cognitive impairment (MCI) and elderly controls,…”
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Association between educational attainment and amyloid deposition across the spectrum from normal cognition to dementia: neuroimaging evidence for protection and compensation by Arenaza-Urquijo, Eider M., Bejanin, Alexandre, Gonneaud, Julie, Wirth, Miranka, La Joie, Renaud, Mutlu, Justine, Gaubert, Malo, Landeau, Brigitte, de la Sayette, Vincent, Eustache, Francis, Chételat, Gaël

“…The brain mechanisms underlying the effect of intellectual enrichment may evolve along the normal aging Alzheimer's disease (AD) cognitive spectrum and may…”
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