The impact of early anti-SARS-CoV-2 antibody production on the length of hospitalization stay among COVID-19 patients

The study provides valuable insights into the sociodemographic characteristics, clinical outcomes, and humoral immune response of those affected by the virus that has devastated every field of human life since 2019; the COVID-19 patients. Firstly, the association among clinical manifestations, comor...

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Bibliographic Details
Published in:	Microbiology spectrum Vol. 11; no. 6; p. e0095923
Main Authors:	de Almeida, Dalziza Victalina, Cezar, Priscila Alves, Fernandes, Thais Freitas Barreto, Schwarz, Marcos Gustavo Araujo, Mendonça-Lima, Leila, Giacoia-Gripp, Carmem Beatriz Wagner, Côrtes, Fernanda Heloise, Lindenmeyer Guimarães, Monick, Pilotto, Jose Henrique, De Sá, Nathalia Beatriz Ramos, Cazote, Andressa da Silva, Gomes, Larissa Rodrigues, Quintana, Marcel de Souza Borges, Ribeiro-Alves, Marcelo, Coelho, Lara Esteves, Geraldo, Kim Mattos, Ribeiro, Maria Pia Diniz, Cardoso, Sandra Wagner, Grinsztejn, Beatriz, Veloso, Valdiléa G, Morgado, Mariza Gonçalves
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 12-12-2023
Subjects:	Clinical Microbiology COVID-19 HIV-1 neutralizing antibodies PLWH pseudovirus Research Article SARS-CoV-2 COVID-19 HIV-1 PLWH pseudovirus neutralizing antibodies SARS-CoV-2
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Summary:	The study provides valuable insights into the sociodemographic characteristics, clinical outcomes, and humoral immune response of those affected by the virus that has devastated every field of human life since 2019; the COVID-19 patients. Firstly, the association among clinical manifestations, comorbidities, and the production of neutralizing antibodies (Nabs) against SARS-CoV-2 is explored. Secondly, varying levels of Nabs among patients are revealed, and a significant correlation between the presence of Nabs and a shorter duration of hospitalization is identified, which highlights the potential role of Nabs in predicting clinical outcomes. Lastly, a follow-up conducted 7 months later demonstrates the progression and persistence of Nabs production in recovered unvaccinated individuals. The study contributes essential knowledge regarding the characteristics of the study population, the early humoral immune response, and the dynamics of Nabs production over time. These findings have significant implications for understanding the immune response to COVID-19 and informing clinical management approaches.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 The authors declare no conflict of interest.
ISSN:	2165-0497 2165-0497
DOI:	10.1128/spectrum.00959-23