Search Results - "Ceyhan, O"

Neural plasticity in pancreatitis and pancreatic cancer by Demir, Ihsan Ekin, Friess, Helmut, Ceyhan, Güralp O.

“…Key Points Neural plasticity is an inherent feature of chronic pancreatitis and pancreatic cancer, and involves neuronal activation at the peripheral, spinal…”
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R0 Versus R1 Resection Matters after Pancreaticoduodenectomy, and Less after Distal or Total Pancreatectomy for Pancreatic Cancer by Demir, Ihsan Ekin, Jäger, Carsten, Schlitter, A Melissa, Konukiewitz, Björn, Stecher, Lynne, Schorn, Stephan, Tieftrunk, Elke, Scheufele, Florian, Calavrezos, Lenika, Schirren, Rebekka, Esposito, Irene, Weichert, Wilko, Friess, Helmut, Ceyhan, Güralp O

“…OBJECTIVE:The aim of this study was to decipher the true importance of R0 versus R1 resection for survival in pancreatic ductal adenocarcinoma (PDAC). SUMMARY…”
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Neoadjuvant Therapy Remodels the Pancreatic Cancer Microenvironment via Depletion of Protumorigenic Immune Cells by Mota Reyes, Carmen, Teller, Steffen, Muckenhuber, Alexander, Konukiewitz, Björn, Safak, Okan, Weichert, Wilko, Friess, Helmut, Ceyhan, Güralp O, Demir, Ihsan Ekin

“…Neoadjuvant therapy (neoTx) has dramatically improved the prognosis of patients with locally advanced and borderline resectable pancreatic ductal…”
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Pancreatic stump closure techniques and pancreatic fistula formation after distal pancreatectomy: Meta-analysis and single-center experience by Tieftrunk, Elke, Demir, Ihsan Ekin, Schorn, Stephan, Sargut, Mine, Scheufele, Florian, Calavrezos, Lenika, Schirren, Rebekka, Friess, Helmut, Ceyhan, Güralp O

“…Pancreatic fistula/PF is the most frequent and feared complication after distal pancreatectomy/DP. However, the safest technique of pancreatic stump closure…”
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Insulin/IGF-driven cancer cell-stroma crosstalk as a novel therapeutic target in pancreatic cancer by Mutgan, Ayse Ceren, Besikcioglu, H Erdinc, Wang, Shenghan, Friess, Helmut, Ceyhan, Güralp O, Demir, Ihsan Ekin

“…Pancreatic ductal adenocarcinoma (PDAC) is unrivalled the deadliest gastrointestinal cancer in the western world. There is substantial evidence implying that…”
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Nerve growth factor & TrkA as novel therapeutic targets in cancer by Demir, Ihsan Ekin, Tieftrunk, Elke, Schorn, Stephan, Friess, Helmut, Ceyhan, Güralp O.

“…In the past 20years, nerve growth factor (NGF) and its receptors TrkA & p75NTR were recognized to be overexpressed in the overwhelming majority of human solid…”
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Investigation of Schwann cells at neoplastic cell sites before the onset of cancer invasion by Demir, Ihsan Ekin, Boldis, Alexandra, Pfitzinger, Paulo L, Teller, Steffen, Brunner, Eva, Klose, Natascha, Kehl, Timo, Maak, Matthias, Lesina, Marina, Laschinger, Melanie, Janssen, Klaus-Peter, Algül, Hana, Friess, Helmut, Ceyhan, Güralp O

“…In neural invasion (NI), cancer cells are classically assumed to actively invade nerves and to cause local recurrence and pain. However, the opposite…”
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Prognosis of sporadic resected small (≤2 cm) nonfunctional pancreatic neuroendocrine tumors – a multi-institutional study by Sallinen, Ville J., Le Large, Tessa Y.S., Tieftrunk, Elke, Galeev, Shamil, Kovalenko, Zahar, Haugvik, Sven-Petter, Antila, Anne, Franklin, Oskar, Martinez-Moneo, Emma, Robinson, Stuart M., Panzuto, Francesco, Regenet, Nicolas, Muffatti, Francesca, Partelli, Stefano, Wiese, Dominik, Ruszniewski, Philippe, Dousset, Bertrand, Edwin, Bjørn, Bartsch, Detlef K., Sauvanet, Alain, Falconi, Massimo, Ceyhan, Güralp O., Gaujoux, Sebastien

“…Malignant potential of small (≤20 mm) nonfunctional pancreatic neuroendocrine tumors (sNF-PNET) is difficult to predict and management remain controversial…”
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Mechanisms of T-Cell Exhaustion in Pancreatic Cancer by Saka, Didem, Gökalp, Muazzez, Piyade, Betül, Cevik, Nedim Can, Arik Sever, Elif, Unutmaz, Derya, Ceyhan, Güralp O., Demir, Ihsan Ekin, Asimgil, Hande

“…T-cell exhaustion is a phenomenon that represents the dysfunctional state of T cells in chronic infections and cancer and is closely associated with poor…”
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Neural influences on human intestinal epithelium in vitro by Krueger, Dagmar, Michel, Klaus, Zeller, Florian, Demir, Ihsan E., Ceyhan, Güralp O., Slotta‐Huspenina, Julia, Schemann, Michael

“…Key points We present the first systematic and, up to now, most comprehensive evaluation of the basic features of epithelial functions, such as basal and…”
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The legacy of a surgeon - in memoriam Dr. İsmail Demir by Demir, Ihsan Ekin, Demir, Elke, Erkan, Mert, Ceyhan, Güralp O., Friess, Helmut

“…In this perspective article, we highlighted some special aspects of being a surgeon that are typically not taught in medical training. Departing from a real…”
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Pancreatic Neuropathy and Neuropathic Pain—A Comprehensive Pathomorphological Study of 546 Cases by Ceyhan, Güralp O, Bergmann, Frank, Kadihasanoglu, Mustafa, Altintas, Burak, Demir, Ihsan E, Hinz, Ulf, Müller, Michael W, Giese, Thomas, Büchler, Markus W, Giese, Nathalia A, Friess, Helmut

“…Background & Aims Chronic pancreatitis (CP) and pancreatic adenocarcinoma (PCa) are characterized by intrapancreatic neural alterations and pain. Our aims were…”
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Pancreatic Ductal Adenocarcinoma Subtyping Using the Biomarkers Hepatocyte Nuclear Factor-1A and Cytokeratin-81 Correlates with Outcome and Treatment Response by Muckenhuber, Alexander, Berger, Anne Katrin, Schlitter, Anna Melissa, Steiger, Katja, Konukiewitz, Björn, Trumpp, Andreas, Eils, Roland, Werner, Jens, Friess, Helmut, Esposito, Irene, Klöppel, Günter, Ceyhan, Güralp O, Jesinghaus, Moritz, Denkert, Carsten, Bahra, Marcus, Stenzinger, Albrecht, Sprick, Martin R, Jäger, Dirk, Springfeld, Christoph, Weichert, Wilko

“…Pancreatic ductal adenocarcinoma (PDAC) is associated with a dismal prognosis and poor therapeutic response to current chemotherapy regimens in unselected…”
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Administration of Gemcitabine After Pancreatic Tumor Resection in Mice Induces an Antitumor Immune Response Mediated by Natural Killer Cells by Gürlevik, Engin, Fleischmann-Mundt, Bettina, Brooks, Jennifer, Demir, Ihsan Ekin, Steiger, Katja, Ribback, Silvia, Yevsa, Tetyana, Woller, Norman, Kloos, Arnold, Ostroumov, Dmitrij, Armbrecht, Nina, Manns, Michael P, Dombrowski, Frank, Saborowski, Michael, Kleine, Moritz, Wirth, Thomas C, Oettle, Helmut, Ceyhan, Güralp O, Esposito, Irene, Calvisi, Diego F, Kubicka, Stefan, Kühnel, Florian

“…Background & Aims Even after potentially curative R0 resection, patients with pancreatic ductal adenocarcinoma (PDAC) have a poor prognosis owing to high rates…”
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Beyond lactate: is there a role for serum lactate measurement in diagnosing acute mesenteric ischemia? by Demir, Ihsan Ekin, Ceyhan, Güralp O, Friess, Helmut

“…Measurement of serum lactate remains the most frequently applied laboratory investigation to diagnose acute mesenteric (intestinal) ischemia. The present…”
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pT but not pN stage of the 8th TNM classification significantly improves prognostication in pancreatic ductal adenocarcinoma by Schlitter, Anna Melissa, Jesinghaus, Moritz, Jäger, Carsten, Konukiewitz, Björn, Muckenhuber, Alexander, Demir, Ihsan Ekin, Bahra, Marcus, Denkert, Carsten, Friess, Helmut, Kloeppel, Günter, Ceyhan, Güralp O., Weichert, Wilko

“…The UICC TNM (tumour-node-metastasis) staging system for pancreatic ductal adenocarcinoma (PDAC) has been a matter of debate over decades because survival…”
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Guidelines for the understanding and management of pain in chronic pancreatitis by Drewes, Asbjørn M., Bouwense, Stefan A.W., Campbell, Claudia M., Ceyhan, Güralp O., Delhaye, Myriam, Demir, Ihsan Ekin, Garg, Pramod K., van Goor, Harry, Halloran, Christopher, Isaji, Shuiji, Neoptolemos, John P., Olesen, Søren S., Palermo, Tonya, Pasricha, Pankaj Jay, Sheel, Andrea, Shimosegawa, Tooru, Szigethy, Eva, Whitcomb, David C., Yadav, Dhiraj

“…Abdominal pain is the foremost complication of chronic pancreatitis (CP). Pain can be related to recurrent or chronic inflammation, local complications or…”
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Early pancreatic cancer lesions suppress pain through CXCL12-mediated chemoattraction of Schwann cells by Demir, Ihsan Ekin, Kujundzic, Kristina, Pfitzinger, Paulo L., Saricaoglu, Ömer Cemil, Teller, Steffen, Kehl, Timo, Reyes, Carmen Mota, Ertl, Linda S., Miao, Zhenhua, Schall, Thomas J., Tieftrunk, Elke, Haller, Bernhard, Diakopoulos, Kalliope Nina, Kurkowski, Magdalena U., Lesina, Marina, Krüger, Achim, Algül, Hana, Friess, Helmut, Ceyhan, Güralp O.

“…Pancreatic ductal adenocarcinoma (PDAC) cells (PCC) have an exceptional propensity to metastasize early into intratumoral, chemokine-secreting nerves. However,…”
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Neural plasticity in the gastrointestinal tract: chronic inflammation, neurotrophic signals, and hypersensitivity by Demir, Ihsan Ekin, Schäfer, Karl-Herbert, Tieftrunk, Elke, Friess, Helmut, Ceyhan, Güralp O.

“…Neural plasticity is not only the adaptive response of the central nervous system to learning, structural damage or sensory deprivation, but also an…”
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Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia by Demir, Ihsan Ekin, Tieftrunk, Elke, Schorn, Stephan, Saricaoglu, Ömer Cemil, Pfitzinger, Paulo L, Teller, Steffen, Wang, Kun, Waldbaur, Christine, Kurkowski, Magdalena U, Wörmann, Sonja Maria, Shaw, Victoria E, Kehl, Timo, Laschinger, Melanie, Costello, Eithne, Algül, Hana, Friess, Helmut, Ceyhan, Güralp O

“…The impact of glia cells during GI carcinogenesis and in cancer pain is unknown. Here, we demonstrate a novel mechanism how Schwann cells (SCs) become…”
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