Search Results - "Ceuppens, Jan L."

Impaired barrier function in patients with house dust mite–induced allergic rhinitis is accompanied by decreased occludin and zonula occludens-1 expression by Steelant, Brecht, MSc, Farré, Ricard, PhD, Wawrzyniak, Paulina, MSc, Belmans, Jochen, MSc, Dekimpe, Emily, MSc, Vanheel, Hanne, PhD, Van Gerven, Laura, MD, PhD, Kortekaas Krohn, Inge, MSc, Bullens, Dominique M.A., MD, PhD, Ceuppens, Jan L., MD, PhD, Akdis, Cezmi A., MD, Boeckxstaens, Guy, MD, PhD, Seys, Sven F., PhD, Hellings, Peter W., MD, PhD

“…Background Tight junction (TJ) defects have recently been associated with asthma and chronic rhinosinusitis. The expression, function, and regulation of nasal…”
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Biological Therapy in Inflammatory Bowel Disease Patients Partly Restores Intestinal Innate Lymphoid Cell Subtype Equilibrium by Creyns, Brecht, Jacobs, Inge, Verstockt, Bram, Cremer, Jonathan, Ballet, Vera, Vandecasteele, Roselien, Vanuytsel, Tim, Ferrante, Marc, Vermeire, Séverine, Van Assche, Gert, Ceuppens, Jan L, Breynaert, Christine

“…Patients with Crohn disease (CD) and ulcerative colitis (UC) suffer from chronic relapsing intestinal inflammation. While many studies focused on adaptive…”
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IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx? by Bullens, Dominique M A, Truyen, Els, Coteur, Liesbeth, Dilissen, Ellen, Hellings, Peter W, Dupont, Lieven J, Ceuppens, Jan L

“…The role of Th2 cells (producing interleukin (IL-)4, IL-5 and IL-13) in allergic asthma is well-defined. A distinct proinflammatory T cell lineage has recently…”
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Probiotics against airway allergy: host factors to consider by Spacova, Irina, Ceuppens, Jan L, Seys, Sven F, Petrova, Mariya I, Lebeer, Sarah

“…The worldwide prevalence of allergic diseases has drastically increased in the past decades. Recent studies underline the importance of microbial exposure for…”
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Innate Lymphoid Cells Are Required to Induce Airway Hyperreactivity in a Murine Neutrophilic Asthma Model by Jonckheere, Anne-Charlotte, Seys, Sven F, Steelant, Brecht, Decaesteker, Tatjana, Dekoster, Kaat, Cremer, Jonathan, Dilissen, Ellen, Schols, Dominique, Iwakura, Yoichiro, Vande Velde, Greetje, Breynaert, Christine, Schrijvers, Rik, Vanoirbeek, Jeroen, Ceuppens, Jan L, Dupont, Lieven J, Bullens, Dominique M A

“…Non-allergic asthma is driven by multiple endotypes of which neutrophilic and pauci-granulocytic asthma have been best established. However, it is still…”
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Crucial Role of Transient Receptor Potential Ankyrin 1 and Mast Cells in Induction of Nonallergic Airway Hyperreactivity in Mice by HOX, Valérie, VANOIRBEEK, Jeroen A, LISTON, Adrian, VOETS, Thomas, VENNEKENS, Rudi, BULLENS, Dominique M. A, DE VRIES, Annick, HOET, Peter, BRAUN, Armin, CEUPPENS, Jan L, TALAVERA, Karel, NEMERY, Benoit, ALPIZAR, Yeranddy A, HELLINGS, Peter W, VOEDISCH, Sabrina, CALLEBAUT, Ina, BOBIC, Sonja, SHARIFY, Ali, DE VOOGHT, Vanessa, VAN GERVEN, Laura, DEVOS, Fien

“…Airway hyperreactivity (AHR) is a key feature of bronchial asthma, and inhalation of irritants may facilitate development of nonallergic AHR. Swimmers exposed…”
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Reciprocal changes of Foxp3 expression in blood and intestinal mucosa in IBD patients responding to infliximab by Li, Zhe, Arijs, Ingrid, De Hertogh, Gert, Vermeire, Séverine, Noman, Maja, Bullens, Dominique, Coorevits, Lieve, Sagaert, Xavier, Schuit, Frans, Rutgeerts, Paul, Ceuppens, Jan L., Van Assche, Gert

“…Background: Immune therapies may act in inflammatory bowel diseases (IBD) by modulating regulatory T cells (Tregs). Therefore, we investigated the effect of…”
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Effects of Epithelial IL-13Rα2 Expression in Inflammatory Bowel Disease by Verstockt, Bram, Perrier, Clémentine, De Hertogh, Gert, Cremer, Jonathan, Creyns, Brecht, Van Assche, Gert, Ferrante, Marc, Ceuppens, Jan L, Vermeire, Séverine, Breynaert, Christine

“…Mucosal IL-13 Receptor alpha 2 ( ) mRNA expression is one of the best predictive markers for primary non-responsiveness to infliximab therapy in patients with…”
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Corrigendum: Innate lymphoid cells are required to induce airway hyperreactivity in a murine neutrophilic asthma model by Jonckheere, Anne-Charlotte, Seys, Sven F., Steelant, Brecht, Decaesteker, Tatjana, Dekoster, Kaat, Cremer, Jonathan, Dilissen, Ellen, Schols, Dominique, Iwakura, Yoichiro, Vande Velde, Greetje, Breynaert, Christine, Schrijvers, Rik, Vanoirbeek, Jeroen, Ceuppens, Jan L., Dupont, Lieven J., Bullens, Dominique M. A.

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Unique gene expression and MR T2 relaxometry patterns define chronic murine dextran sodium sulphate colitis as a model for connective tissue changes in human Crohn's disease by Breynaert, Christine, Dresselaers, Tom, Perrier, Clémentine, Arijs, Ingrid, Cremer, Jonathan, Van Lommel, Leentje, Van Steen, Kristel, Ferrante, Marc, Schuit, Frans, Vermeire, Séverine, Rutgeerts, Paul, Himmelreich, Uwe, Ceuppens, Jan L, Geboes, Karel, Van Assche, Gert

“…Chronically relapsing inflammation, tissue remodeling and fibrosis are hallmarks of inflammatory bowel diseases. The aim of this study was to investigate…”
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Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease by Suenaert, Peter, Bulteel, Veerle, Lemmens, Liesbeth, Noman, Maja, Geypens, Benny, Van Assche, Gert, Geboes, Karel, Ceuppens, Jan L, Rutgeerts, Paul

“…A primary defect of the tight junctions and, hence, increased intestinal epithelial permeability has been proposed as a basic pathogenic event in Crohn's…”
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Anti-Tumor Necrosis Factor Therapy Restores Peripheral Blood B-cell Subsets and CD40 Expression in Inflammatory Bowel Diseases by Li, Zhe, Vermeire, Séverine, Bullens, Dominique, Ferrante, Marc, Van Steen, Kristel, Noman, Maja, Bossuyt, Xavier, Rutgeerts, Paul, Ceuppens, Jan L, Van Assche, Gert

“…Anti-tumor necrosis factor (TNF) therapy has become a standard therapy for severe inflammatory bowel diseases (IBD), but its effect on B lymphocytes is largely…”
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Haptoglobin deficiency facilitates the development of autoimmune inflammation by Galicia, Georgina, Maes, Wim, Verbinnen, Bert, Kasran, Ahmad, Bullens, Dominique, Arredouani, Mohamed, Ceuppens, Jan L

“…Haptoglobin (HP) is an acute phase protein synthesized by liver cells in response to IL-6. HP has been demonstrated to modulate the immune response and to have…”
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Fibrogenesis in chronic murine colitis is independent of innate lymphoid cells by Creyns, Brecht, Cremer, Jonathan, De Hertogh, Gert, Boon, Louis, Ferrante, Marc, Vermeire, Séverine, Van Assche, Gert, Ceuppens, Jan L., Breynaert, Christine

“…Introduction Insight in the pathogenesis of intestinal fibrosis is an unmet medical need in inflammatory bowel diseases. Studies in murine models and human…”
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Selective nasal allergen provocation induces substance P-mediated bronchial hyperresponsiveness by Hens, Greet, Raap, Ulrike, Vanoirbeek, Jeroen, Meyts, Isabelle, Callebaut, Ina, Verbinnen, Bert, Vanaudenaerde, Bart M, Cadot, Pascal, Nemery, Benoit, Bullens, Dominique M A, Ceuppens, Jan L, Hellings, Peter W

“…Although the concept of "global airway allergy" has become widely accepted during recent years, nasobronchial interaction and its mechanisms remain…”
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Haptoglobin dampens endotoxin‐induced inflammatory effects both in vitro and in vivo by Arredouani, Mohamed S., Kasran, Ahmad, Vanoirbeek, Jeroen A., Berger, Frank G., Baumann, Heinz, Ceuppens, Jan L.

“…Summary We report that haptoglobin, an acute‐phase protein produced by liver cells in response to interleukin‐6 (IL‐6), can modulate the inflammatory response…”
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Impact of luxS and Suppressor Mutations on the Gastrointestinal Transit of Lactobacillus rhamnosus GG by Lebeer, Sarah, Claes, Ingmar J.J, Verhoeven, Tine L.A, Shen, Chong, Lambrichts, Ivo, Ceuppens, Jan L, Vanderleyden, Jos, De Keersmaecker, Sigrid C.J

“…It is generally believed that probiotic bacteria need to survive gastrointestinal transit to exert a health-promoting effect. In this study, a genuine luxS…”
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IL-12 Contributes to Allergen-Induced Airway Inflammation in Experimental Asthma by Meyts, Isabelle, Hellings, Peter W, Hens, Greet, Vanaudenaerde, Bart M, Verbinnen, Bert, Heremans, Hubertine, Matthys, Patrick, Bullens, Dominique M, Overbergh, Lut, Mathieu, Chantal, De Boeck, Kris, Ceuppens, Jan L

“…Lack of sufficient IL-12 production has been suggested to be one of the basic underlying mechanisms in atopy, but a potential role of IL-12 in established…”
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Immunogenicity Evaluation of Subcutaneous Administration of Peptide Hydrolysate from Lolium Perenne (gpASIT+™) in Combination with Bacterial HSP70 (DnaK) in Patients with Seasonal Allergic Rhinitis: A Double Blind Placebo Controlled Trial by Shamji, Mohamed H., PhD, FAAAAI, Ceuppens, Jan L., MD, PhD, Hellings, Peter W., MD, PhD, Durham, Stephen, MA, MD, FRCP, Duchateau, Jean, PhD, Parkin, Rebecca, BSc, Legon, Thierry, MBA, Pirotton, Sabine, PhD

“…Post-hoc analysis showed 4/9 patients who received low-dose gpASIT+(TM)/DnaK (<105 [micro]g) had an improvement of symptom (-53% compared to placebo) and…”
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Explorative study on patient's perceived knowledge level, expectations, preferences and fear of side effects for treatment for allergic rhinitis by Hellings, Peter W, Dobbels, Fabienne, Denhaerynck, Kris, Piessens, Mark, Ceuppens, Jan L, De Geest, Sabina

“…Background In spite of the high prevalence of allergic rhinitis (AR) and the evidence‐based guidelines for treatment, little is known about the patients’…”
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