Plasma lipocalin-2 levels in pregnancy

Plasma lipocalin-2 levels in pregnancy

OBJECTIVE. To evaluate plasma levels of lipocalin-2, which is a novel adipokine associated with obesity and insulin resistance, in pregnant women. Prospective case-control study. University hospital. Pregnant women with pre-pregnancy body mass index >25kg/m(2) (overweight; n=29) and body mass ind...

Full description

Saved in:
Bibliographic Details
Published in:Acta obstetricia et gynecologica Scandinavica Vol. 91; no. 1; p. 112
Main Authors: Cesur, Semra, Yucel, Aykan, Noyan, Volkan, Sagsoz, Nevin
Format: Journal Article
Language:English
Published: United States 01-01-2012
Subjects:
Acute-Phase Proteins
Adolescent
Adult
Biomarkers - blood
Blood Glucose - metabolism
Body Mass Index
Case-Control Studies
Female
Humans
Insulin - blood
Insulin Resistance
Lipocalin-2
Lipocalins - blood
Overweight - blood
Pregnancy
Pregnancy Complications - blood
Prospective Studies
Proto-Oncogene Proteins - blood
Reference Values
Young Adult
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:OBJECTIVE. To evaluate plasma levels of lipocalin-2, which is a novel adipokine associated with obesity and insulin resistance, in pregnant women. Prospective case-control study. University hospital. Pregnant women with pre-pregnancy body mass index >25kg/m(2) (overweight; n=29) and body mass index <25kg/m(2) (n=27), whose gestational ages were between 24 and 28 weeks, as study groups and nonpregnant control women with body mass index <25kg/m(2) (n=29). Plasma lipocalin-2 levels, fasting plasma glucose and fasting plasma insulin levels; homeostasis model assessment insulin resistance index and fasting plasma glucose/fasting plasma insulin ratio were measured for each subject. Comparisons among the groups and correlations for lipocalin-2 and the parameters of insulin resistance. Plasma lipocalin-2 levels among the pregnant women were significantly higher than those of the control group (p<0.001 for both group comparisons). Lipocalin-2 levels were significantly higher in the group with pre-pregnancy body mass index >25kg/m(2) compared with the group with pre-pregnancy body mass index <25kg/m(2) (p=0.003). Lipocalin-2 levels were positively correlated with homeostasis model assessment insulin resistance index and fasting plasma insulin and negatively correlated with fasting plasma glucose/fasting plasma insulin ratio in both pregnant groups. Lipocalin-2 was found to be higher in pregnant women, especially when pre-pregnancy body mass index was >25kg/m(2) , and it was correlated with markers of insulin resistance.
ISSN:1600-0412
DOI:10.1111/j.1600-0412.2011.01158.x