Search Results - "Cesta, M C"

Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2 non‐competitive allosteric inhibitor by Bertini, R, Barcelos, LS, Beccari, AR, Cavalieri, B, Moriconi, A, Bizzarri, C, Di Benedetto, P, Di Giacinto, C, Gloaguen, I, Galliera, E, Corsi, MM, Russo, RC, Andrade, SP, Cesta, MC, Nano, G, Aramini, A, Cutrin, JC, Locati, M, Allegretti, M, Teixeira, MM

“…BACKGROUND AND PURPOSE DF 2156A is a new dual inhibitor of IL‐8 receptors CXCR1 and CXCR2 with an optimal pharmacokinetic profile. We characterized its binding…”
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Inhibition of C5aR1 as a promising approach to treat taxane-induced neuropathy by Cristiano, C., Giorgio, C., Cocchiaro, P., Boccella, S., Cesta, M.C., Castelli, V., Liguori, F.M., Cuozzo, M.R., Brandolini, L., Russo, R., Allegretti, M.

“…•CIPN is a common and disabling side effect of antitumor agents, including paclitaxel, resulting in progressive damage of peripheral nerves.•Taxanes are…”
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Synthesis of phenothiazine derivatives as potential inhibitors of phospholipase C by Brufani, M, Cesta, M C, Filocamo, L, Lappa, S, Marta, M, Pomponi, M, Meroni, C, Pagella, P G

“…In order to study the structure-activity relationships of phenothiazine derivatives inhibiting phosphatidylinositol-specific phospholipase C (PI-PLC), the…”
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Design of Noncompetitive Interleukin-8 Inhibitors Acting on CXCR1 and CXCR2 by Moriconi, Alessio, Cesta, Maria Candida, Cervellera, Maria Neve, Aramini, Andrea, Coniglio, Silvia, Colagioia, Sandro, Beccari, Andrea Rosario, Bizzarri, Cinzia, Cavicchia, Michela Rita, Locati, Massimo, Galliera, Emanuela, Di Benedetto, Paola, Vigilante, Paolo, Bertini, Riccardo, Allegretti, Marcello

“…Chemokines CXCL8 and CXCL1 play a key role in the recruitment of neutrophils at the site of inflammation. CXCL8 binds two membrane receptors, CXCR1 and CXCR2,…”
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Synthesis of tritiated 1-octadecyl-phosphothiolyl-myo-[1-3H]-inositol. A new inhibitor of phosphatidylinositol-specific phospholipase-C by Angelini, G., Margonelli, A., Ragni, P., Sparapani, C., Cellai, L., Iannelli, M. A., Cesta, M. C., Lappa, S.

“…The title myo‐[1‐3H]‐Inositol derivative was synthesized and characterized by tritium‐N.M.R. The unlabelled compound proved a potent inhibitor of the cellular…”
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Synthesis of tritiated 1-octadecylphosphothiolyl-myo-[1- super(3)H]-inositol. A new inhibitor of phosphatidylinositol-specific phospholipase-C by Angelini, G, Margonelli, A, Ragni, P, Sparapani, C, Cellai, L, Iannelli, MA, Cesta, M C, Lappa, S

“…The title myo-[1- super(3)H]-Inositol derivative was synthesized and characterized by tritium-N.M.R.. The unlabelled compound proved a potent inhibitor of the…”
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Synthesis of some carbamates of myo-inositol by Brufani, M, Cesta, M C, Donnarumma, L, Filocamo, L, Gostoli, G, Lappa, S, Ferrari, E, Pagella, P G

“…The syntheses are described of the 1-O-carbamoyl (11), 1-O-carbamoyl-2-O-stearoyl (10), 1-O-(acetylcarbamoyl)-2-O-stearoyl (12), 1-O-(heptylcarbamoyl) (13),…”
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Synthesis of acylphosphonyl analogues of phosphatidyl-myo-inositol as inhibitors of phosphatidylinositol-specific phospholipase C by Alisi, M A, Brufani, M, Filocamo, L, Cellai, L, Iannelli, M A, Cesta, M C, Lappa, S

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2-Arylpropionic CXC Chemokine Receptor 1 (CXCR1) Ligands as Novel Noncompetitive CXCL8 Inhibitors by Allegretti, Marcello, Bertini, Riccardo, Cesta, Maria Candida, Bizzarri, Cinzia, Di Bitondo, Rosa, Di Cioccio, Vito, Galliera, Emanuela, Berdini, Valerio, Topai, Alessandra, Zampella, Giuseppe, Russo, Vincenzo, Di Bello, Nicoletta, Nano, Giuseppe, Nicolini, Luca, Locati, Massimo, Fantucci, Piercarlo, Florio, Saverio, Colotta, Francesco

“…The CXC chemokine CXCL8/IL-8 plays a major role in the activation and recruitment of polymorphonuclear (PMN) cells at inflammatory sites. CXCL8 activates PMNs…”
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Predicting Human Serum Albumin Affinity of Interleukin-8 (CXCL8) Inhibitors by 3D-QSPR Approach by Aureli, Loretta, Cruciani, Gabriele, Cesta, Maria Candida, Anacardio, Roberto, De Simone, Lucio, Moriconi, Alessio

“…A novel class of 2-(R)-phenylpropionamides has been recently reported to inhibit in vitro and in vivo interleukin-8 (CXCL8)-induced biological activities…”
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One-pot, new stereoselective synthesis of endo-tropanamine by Allegretti, Marcello, Berdini, Valerio, Cesta, M.Candida, Curti, Roberto, Nicolini, Luca, Topai, Alessandra

“…A palladium-catalysed reduction of ketones to primary amines by reaction with ammonium formate in aqueous methanol is described. The proposed method provides a…”
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A modified palladium catalysed reductive amination procedure by Berdini, Valerio, Cesta, Maria C, Curti, Roberto, D'Anniballe, Gaetano, Bello, Nicoletta Di, Nano, Giuseppe, Nicolini, Luca, Topai, Alessandra, Allegretti, Marcello

“…New, extended applications of a modified palladium catalysed reductive amination procedure are described; a mechanistic hypothesis alternative to the common…”
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Acylmethanesulfonamides as new acylating agents for primary amines by Coniglio, Silvia, Aramini, Andrea, Cesta, M.Candida, Colagioia, Sandro, Curti, Roberto, D'Alessandro, Fabrizio, D'Anniballe, Gaetano, D'Elia, Valerio, Nano, Giuseppe, Orlando, Valerie, Allegretti, Marcello

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Synthesis of E-Aryl Ethenesulfonamides:  A Simple One-Pot, Two-Step Procedure from 1-Hydroxy-1-arylalkanes by Aramini, Andrea, Cesta, Maria C, Coniglio, Silvia, Bijani, Christian, Colagioia, Sandro, D'Eli, Valerio, Allegretti, Marcello

“…The unusual reactivity of 1-phenyl-1-ethanesulfonic acid in thionyl chloride was investigated. Mechanistic considerations led us to set up a new and efficient…”
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Synthesis and structure-activity relationships of new acetylcholinesterase inhibitors: Morpholinoalkylcarbamoyloxyeseroline derivatives by Alisi, Maria A., Brufani, Mario, Filocamo, Luigi, Gostoli, Gianluca, Licandro, Emanuela, Cesta, M.Candida, Lappa, Sperandina, Marchesini, Donata, Pagella, P.

“…Several new potent acetylcholinesterase inhibitors have been synthesised as potential drugs for the treatment of Alzheimer's disease. Heptylphysostigmine…”
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