Search Results - "Cesarz, David"

N-Hydroxy-3-phenyl-2-propenamides as Novel Inhibitors of Human Histone Deacetylase with in Vivo Antitumor Activity:  Discovery of (2E)-N-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824) by Remiszewski, Stacy W, Sambucetti, Lidia C, Bair, Kenneth W, Bontempo, John, Cesarz, David, Chandramouli, Nagarajan, Chen, Ru, Cheung, Min, Cornell-Kennon, Susan, Dean, Karl, Diamantidis, George, France, Dennis, Green, Michael A, Howell, Kobporn Lulu, Kashi, Rina, Kwon, Paul, Lassota, Peter, Martin, Mary S, Mou, Yin, Perez, Lawrence B, Sharma, Sushil, Smith, Troy, Sorensen, Eric, Taplin, Francis, Trogani, Nancy, Versace, Richard, Walker, Heather, Weltchek-Engler, Susan, Wood, Alexander, Wu, Arthur, Atadja, Peter

“…A series of N-hydroxy-3-phenyl-2-propenamides were prepared as novel inhibitors of human histone deacetylase (HDAC). These compounds were potent enzyme…”
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The Synthesis of a Novel Inhibitor of B-Raf Kinase by Denni-Dischert, Donatienne, Marterer, Wolfgang, Bänziger, Markus, Yusuff, Naeem, Batt, David, Ramsey, Tim, Geng, Peng, Michael, Walter, Wang, Run-Ming B, Taplin, Francis, Versace, Richard, Cesarz, David, Perez, Lawrence B

“…A scaleable synthetic route to [4,7‘]bis-isoquinolinyl-1-yl-(2-tert-butyl-pyrimidine-5-yl)amine (1), an inhibitor of B-Raf kinase is described. The key step in…”
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Synthesis and Antitumor Activity of Ester-Modified Analogues of Bengamide B by Kinder, Frederick R, Versace, Richard W, Bair, Kenneth W, Bontempo, John M, Cesarz, David, Chen, Steven, Crews, Phillip, Czuchta, Ania M, Jagoe, Christopher T, Mou, Yin, Nemzek, Raphael, Phillips, Penny E, Tran, Long D, Wang, RunMing, Weltchek, Susan, Zabludoff, Sonya

“…Bengamide B, a novel sponge-derived marine natural product with broad spectrum antitumor activity, was not suitable for further preclinical development because…”
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Tricyclic Farnesyl Protein Transferase Inhibitors:  Crystallographic and Calorimetric Studies of Structure−Activity Relationships by Strickland, Corey L, Weber, Patricia C, Windsor, William T, Wu, Zhen, Le, Hung V, Albanese, Margaret M, Alvarez, Carmen S, Cesarz, David, del Rosario, Joycelyn, Deskus, Jeffrey, Mallams, Alan K, Njoroge, F. George, Piwinski, John J, Remiszewski, Stacy, Rossman, Randall R, Taveras, Arthur G, Vibulbhan, Bancha, Doll, Ronald J, Girijavallabhan, Viyyoor M, Ganguly, Ashit K

“…Crystallographic and thermodynamic studies of farnesyl protein transferase (FPT) complexed with novel tricyclic inhibitors provide insights into the observed…”
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Interaction of a Novel GDP Exchange Inhibitor with the Ras Protein by Ganguly, Ashit K, Wang, Yu-Sen, Pramanik, Birendra N, Doll, Ronald J, Snow, Mark E, Taveras, Arthur G, Remiszewski, Stacy, Cesarz, David, del Rosario, J, Vibulbhan, Bancha, Brown, Joan E, Kirschmeier, Paul, Huang, Eric C, Heimark, Larry, Tsarbopoulos, Anthony, Girijavallabhan, Viyyoor M, Aust, Robert M, Brown, Edward L, DeLisle, Dorothy M, Fuhrman, Shella A, Hendrickson, Thomas F, Kissinger, Charles R, Love, Robert A, Sisson, Wess A, Villafranca, J. Ernest, Webber, Steve E

“…Mutated, tumorigenic Ras is present in a variety of human tumors. Compounds that inhibit tumorigenic Ras function may be useful in the treatment of Ras-related…”
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N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: Discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]-phen yl]-2-propenamide (NVP-LAQ824) by REMISZEWSKI, Stacy W, SAMBUCETTI, Lidia C, DIAMANTIDIS, George, FRANCE, Dennis, GREEN, Michael A, HOWELL, Kobporn Lulu, KASHI, Rina, KWON, Paul, LASSOTA, Peter, MARTIN, Mary S, YIN MOU, PEREZ, Lawrence B, BAIR, Kenneth W, SHARMA, Sushil, SMITH, Troy, SORENSEN, Eric, TAPLIN, Francis, TROGANI, Nancy, VERSACE, Richard, WALKER, Heather, WELTCHEK-ENGLER, Susan, WOOD, Alexander, WU, Arthur, BONTEMPO, John, ATADJA, Peter, CESARZ, David, CHANDRAMOULI, Nagarajan, RU CHEN, MIN CHEUNG, CORNELL-KENNON, Susan, DEAN, Karl

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