Search Results - "Cesaro, Samuele"
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Functional Characterization of a Spectrum of Genetic Variants in a Family with Succinic Semialdehyde Dehydrogenase Deficiency
Published in International journal of molecular sciences (11-05-2024)“…Succinic semialdehyde dehydrogenase (SSADH) is a mitochondrial enzyme involved in the catabolism of the neurotransmitter γ-amino butyric acid. Pathogenic…”
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Conformational Stabilization of Gp41-Mimetic Miniproteins Opens Up New Ways of Inhibiting HIV-1 Fusion
Published in International journal of molecular sciences (03-03-2022)“…Inhibition of the HIV-1 fusion process constitutes a promising strategy to neutralize the virus at an early stage before it enters the cell. In this process,…”
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Extremely Thermostabilizing Core Mutations in Coiled-Coil Mimetic Proteins of HIV-1 gp41 Produce Diverse Effects on Target Binding but Do Not Affect Their Inhibitory Activity
Published in Biomolecules (Basel, Switzerland) (12-04-2021)“…A promising strategy to neutralize HIV-1 is to target the gp41 spike subunit to block membrane fusion with the cell. We previously designed a series of…”
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Insight into the molecular mechanism underlying the inhibition of α-synuclein aggregation by hydroxytyrosol
Published in Biochemical pharmacology (01-03-2020)“…[Display omitted] Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease in the elderly people. To date, drugs able to reverse the…”
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Phenotypic correlates of structural and functional protein impairments resultant from ALDH5A1 variants
Published in Human genetics (01-12-2023)“…To investigate the genotype-to-protein-to-phenotype correlations of succinic semialdehyde dehydrogenase deficiency (SSADHD), an inherited metabolic disorder of…”
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