Search Results - "Cesari, Nicola"

Pharmacological characterization of a highly selective Rho kinase (ROCK) inhibitor and its therapeutic effects in experimental pulmonary hypertension by Cantoni, Silvia, Cavalli, Stefano, Pastore, Fiorella, Accetta, Alessandro, Pala, Daniele, Vaccaro, Fabio, Cesari, Nicola, De Logu, Francesco, Nassini, Romina, Villetti, Gino, Facchinetti, Fabrizio

“…Studies on the role of Rho-associated protein kinase (ROCK) in experimental pulmonary artery hypertension (PAH) relies mainly on the use of pharmacological…”
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Functional magnetic resonance imaging reveals different neural substrates for the effects of orexin-1 and orexin-2 receptor antagonists by Gozzi, Alessandro, Turrini, Giuliano, Piccoli, Laura, Massagrande, Mario, Amantini, David, Antolini, Marinella, Martinelli, Prisca, Cesari, Nicola, Montanari, Dino, Tessari, Michela, Corsi, Mauro, Bifone, Angelo

“…Orexins are neuro-modulatory peptides involved in the control of diverse physiological functions through interaction with two receptors, orexin-1 (OX1R) and…”
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Development and validation of a high-throughput method for the quantitative analysis of d-amphetamine in rat blood using liquid chromatography/MS 3 on a hybrid triple quadrupole-linear ion trap mass spectrometer and its application to a pharmacokinetic study by Cesari, Nicola, Fontana, Stefano, Montanari, Dino, Braggio, Simone

“…Amphetamines are a group of sympathomimetic drugs that exhibit strong central nervous system stimulant effects. d-Amphetamine ((+)-alpha-methylphenetylamine)…”
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Building in-house PBPK modelling tools for oral drug administration from literature information by Grandoni, Silvia, Cesari, Nicola, Brogin, Giandomenico, Puccini, Paola, Magni, Paolo

“…The interest in using physiologically-based pharmacokinetic (PBPK) models as a support to the drug development decision making process has rapidly increased in…”
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Impact of simulated lung fluid components on the solubility of inhaled drugs and predicted in vivo performance by Radivojev, Snezana, Luschin-Ebengreuth, Gerfried, Pinto, Joana T., Laggner, Peter, Cavecchi, Alessandro, Cesari, Nicola, Cella, Massimo, Melli, Fabrizio, Paudel, Amrit, Fröhlich, Eleonore

“…[Display omitted] Orally inhaled products (OIPs) are gaining increased attention, as pulmonary delivery is a preferred route for the treatment of various…”
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Inter-compound and Intra-compound Global Sensitivity Analysis of a Physiological Model for Pulmonary Absorption of Inhaled Compounds by Melillo, Nicola, Grandoni, Silvia, Cesari, Nicola, Brogin, Giandomenico, Puccini, Paola, Magni, Paolo

“…In recent years, global sensitivity analysis (GSA) has gained interest in physiologically based pharmacokinetics (PBPK) modelling and simulation from…”
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Dissecting the Pharmacodynamics and Pharmacokinetics of MSCs to Overcome Limitations in Their Clinical Translation by Salvadori, Michela, Cesari, Nicola, Murgia, Alba, Puccini, Paola, Riccardi, Benedetta, Dominici, Massimo

“…Recently, mesenchymal stromal stem cells (MSCs) have been proposed as therapeutic agents because of their promising preclinical features and good safety…”
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P219 - Developing a class of orally active drugs with unusual in vitro ADME properties: The role of PBPK modelling in the discovery process by Stefani, Mariarita, Cesari, Nicola, Brogin, Giandomenico, Salvadori, Michela, Puccini, Paola

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Discovery, Multiparametric Optimization, and Solid-State Driven Identification of CHF-6550, a Novel Soft Dual Pharmacology Muscarinic Antagonist and β 2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases by Carzaniga, Laura, Linney, Ian D, Rizzi, Andrea, Schmidt, Wolfgang, Knight, Christopher K, Mileo, Valentina, Amadei, Francesco, Pastore, Fiorella, Miglietta, Daniela, Cesari, Nicola, Riccardi, Benedetta, Mazzucato, Roberta, Ghidini, Eleonora, Blackaby, Wesley P, Patacchini, Riccardo, Battipaglia, Loredana, Villetti, Gino, Puccini, Paola, Catinella, Silvia, Civelli, Maurizio, Rancati, Fabio

“…Clinical guidelines for COPD and asthma recommend inhaled β-adrenergic agonists, muscarinic antagonists, and, for frequent exacerbators, inhaled…”
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Discovery, Multiparametric Optimization, and Solid-State Driven Identification of CHF-6550, a Novel Soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases by Carzaniga, Laura, Linney, Ian D., Rizzi, Andrea, Schmidt, Wolfgang, Knight, Christopher K., Mileo, Valentina, Amadei, Francesco, Pastore, Fiorella, Miglietta, Daniela, Cesari, Nicola, Riccardi, Benedetta, Mazzucato, Roberta, Ghidini, Eleonora, Blackaby, Wesley P., Patacchini, Riccardo, Battipaglia, Loredana, Villetti, Gino, Puccini, Paola, Catinella, Silvia, Civelli, Maurizio, Rancati, Fabio

“…Clinical guidelines for COPD and asthma recommend inhaled β-adrenergic agonists, muscarinic antagonists, and, for frequent exacerbators, inhaled…”
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Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β 2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD) by Rancati, Fabio, Linney, Ian D, Rizzi, Andrea, Delcanale, Maurizio, Knight, Chris K, Schmidt, Wolfgang, Pastore, Fiorella, Riccardi, Benedetta, Mileo, Valentina, Carnini, Chiara, Cesari, Nicola, Blackaby, Wesley P, Patacchini, Riccardo, Carzaniga, Laura

“…The targeting of both the muscarinic and β-adrenergic pathways is a well validated therapeutic approach for the treatment of chronic obstructive pulmonary…”
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Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD) by Rancati, Fabio, Linney, Ian D., Rizzi, Andrea, Delcanale, Maurizio, Knight, Chris K., Schmidt, Wolfgang, Pastore, Fiorella, Riccardi, Benedetta, Mileo, Valentina, Carnini, Chiara, Cesari, Nicola, Blackaby, Wesley P., Patacchini, Riccardo, Carzaniga, Laura

“…[Display omitted] The targeting of both the muscarinic and β-adrenergic pathways is a well validated therapeutic approach for the treatment of chronic…”
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Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases by Carzaniga, Laura, Linney, Ian D., Rizzi, Andrea, Delcanale, Maurizio, Schmidt, Wolfgang, Knight, Christopher K., Pastore, Fiorella, Miglietta, Daniela, Carnini, Chiara, Cesari, Nicola, Riccardi, Benedetta, Mileo, Valentina, Venturi, Luca, Moretti, Elisa, Blackaby, Wesley P., Patacchini, Riccardo, Accetta, Alessandro, Biagetti, Matteo, Bassani, Franco, Tondelli, Marina, Murgo, Annalisa, Battipaglia, Loredana, Villetti, Gino, Puccini, Paola, Catinella, Silvia, Civelli, Maurizio, Rancati, Fabio

“…The development of molecules embedding two distinct pharmacophores acting as muscarinic antagonists and β2 agonists (MABAs) promises to be an excellent…”
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Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β 2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases by Carzaniga, Laura, Linney, Ian D., Rizzi, Andrea, Delcanale, Maurizio, Schmidt, Wolfgang, Knight, Christopher K., Pastore, Fiorella, Miglietta, Daniela, Carnini, Chiara, Cesari, Nicola, Riccardi, Benedetta, Mileo, Valentina, Venturi, Luca, Moretti, Elisa, Blackaby, Wesley P., Patacchini, Riccardo, Accetta, Alessandro, Biagetti, Matteo, Bassani, Franco, Tondelli, Marina, Murgo, Annalisa, Battipaglia, Loredana, Villetti, Gino, Puccini, Paola, Catinella, Silvia, Civelli, Maurizio, Rancati, Fabio

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Design, Synthesis, and Activity of a Novel Series of Pyridazine-Based ALK5 Inhibitors by Pala, Daniele, Ronchi, Paolo, Rescigno, Donatella, Bertani, Barbara, Capelli, Anna Maria, Guariento, Sara, Marchini, Gessica, Milioli, Marco, Cesari, Nicola, Federico, Giuseppina, Grandi, Andrea, Stellari, Franco F., Fernandez, Sergio Xanxo, Pappani, Alice, Venturi, Luca, Biagetti, Matteo, Civelli, Maurizio, Semeraro, Teresa, Bianchi, Federica, Trist, Iuni M. L., Remelli, Rosaria, Armani, Elisabetta, Pizzirani, Daniela

“…ALK5 inhibitors represent an attractive therapeutic approach for the treatment of a variety of pathologies, including cancer and fibrosis. Herein, we report…”
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The Young-Feynman two-slits experiment with single electrons: Build-up of the interference pattern and arrival-time distribution using a fast-readout pixel detector by Frabboni, Stefano, Gabrielli, Alessandro, Carlo Gazzadi, Gian, Giorgi, Filippo, Matteucci, Giorgio, Pozzi, Giulio, Cesari, Nicola Semprini, Villa, Mauro, Zoccoli, Antonio

“…The two-slits experiment for single electrons has been carried out by inserting in a conventional transmission electron microscope a thick sample with two…”
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Development and validation of a high-throughput method for the quantitative analysis of D-amphetamine in rat blood using liquid chromatography/MS3 on a hybrid triple quadrupole-linear ion trap mass spectrometer and its application to a pharmacokinetic study by Cesari, Nicola, Fontana, Stefano, Montanari, Dino, Braggio, Simone

“…Amphetamines are a group of sympathomimetic drugs that exhibit strong central nervous system stimulant effects. D-Amphetamine ((+)-alpha-methylphenetylamine)…”
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Development and validation of a high-throughput method for the quantitative analysis of D-amphetamine in rat blood using liquid chromatography/MS3 on a hybrid triple quadrupole-linear ion trap mass spectrometer and its application to a pharmacokinetics study by CESARI, Nicola, FONTANA, Stefano, MONTANARI, Dino, BRAGGIO, Simone

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In vivo rat PK profiling in drug discovery: new challenges by Zonzini, Laura, Bianchi, Federica, Cesari, Nicola, Sartori, Matteo

“…The importance of evaluating drug metabolism and pharmacokinetic (DMPK) properties very early in the drug discovery process in order to reduce attrition during…”
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