Search Results - "Cesare, Anthony J."

Alternative lengthening of telomeres: models, mechanisms and implications by Reddel, Roger R, Cesare, Anthony J

“…Key Points About 10% of all cancers, including some that have a particularly poor prognosis, use the alternative lengthening of telomeres (ALT) pathway to…”
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The Telomere Deprotection Response Is Functionally Distinct from the Genomic DNA Damage Response by Cesare, Anthony J., Hayashi, Makoto T., Crabbe, Laure, Karlseder, Jan

“…Loss of chromosome end protection through telomere erosion is a hallmark of aging and senescence. Here we developed an experimental system that mimics…”
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Cell death during crisis is mediated by mitotic telomere deprotection by Hayashi, Makoto T., Cesare, Anthony J., Rivera, Teresa, Karlseder, Jan

“…Cells that bypass senescence in the absence of the p53 tumour suppressor protein have shortened telomeres that undergo fusion, and these fusions trigger…”
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Telomere Loop Dynamics in Chromosome End Protection by Van Ly, David, Low, Ronnie Ren Jie, Frölich, Sonja, Bartolec, Tara K., Kafer, Georgia R., Pickett, Hilda A., Gaus, Katharina, Cesare, Anthony J.

“…Telomeres regulate DNA damage response (DDR) and DNA repair activity at chromosome ends. How telomere macromolecular structure contributes to ATM regulation…”
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A three-state model of telomere control over human proliferative boundaries by Cesare, Anthony J, Karlseder, Jan

“…Graphical abstract Highlights ► Human telomeres are protected from the DDR by a higher-order structure. ► Intermediate-state telomeres are susceptible to a DDR…”
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Phasor histone FLIM-FRET microscopy quantifies spatiotemporal rearrangement of chromatin architecture during the DNA damage response by Lou, Jieqiong, Scipioni, Lorenzo, Wright, Belinda K., Bartolec, Tara K., Zhang, Jessie, Masamsetti, V. Pragathi, Gaus, Katharina, Gratton, Enrico, Cesare, Anthony J., Hinde, Elizabeth

“…To investigate how chromatin architecture is spatiotemporally organized at a double-strand break (DSB) repair locus, we established a biophysical method to…”
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Five dysfunctional telomeres predict onset of senescence in human cells by Kaul, Zeenia, Cesare, Anthony J, Huschtscha, Lily I, Neumann, Axel A, Reddel, Roger R

“…Replicative senescence is accompanied by a telomere‐specific DNA damage response (DDR). We found that DDR+ telomeres occur spontaneously in early‐passage…”
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Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions by Pickett, Hilda A, Cesare, Anthony J, Napier, Christine E, Reddel, Roger R, Cohen, Scott B, Kaul, Zeenia, Neumann, Axel A

“…Telomeric DNA is protected by the shelterin complex, whose disruption triggers DNA-damage responses, checkpoint activation and chromosomal fusions. Now…”
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Human Telomeres Are Tethered to the Nuclear Envelope during Postmitotic Nuclear Assembly by Crabbe, Laure, Cesare, Anthony J., Kasuboski, James M., Fitzpatrick, James A.J., Karlseder, Jan

“…Telomeres are essential for nuclear organization in yeast and during meiosis in mice. Exploring telomere dynamics in living human cells by advanced time-lapse…”
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Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection by Masamsetti, V. Pragathi, Low, Ronnie Ren Jie, Mak, Ka Sin, O’Connor, Aisling, Riffkin, Chris D., Lamm, Noa, Crabbe, Laure, Karlseder, Jan, Huang, David C. S., Hayashi, Makoto T., Cesare, Anthony J.

“…Mitotic catastrophe is a broad descriptor encompassing unclear mechanisms of cell death. Here we investigate replication stress-driven mitotic catastrophe in…”
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The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation by Nelson, Christopher B., Rogers, Samuel, Roychoudhury, Kaushik, Tan, Yaw Sing, Atkinson, Caroline J., Sobinoff, Alexander P., Tomlinson, Christopher G., Hsu, Anton, Lu, Robert, Dray, Eloise, Haber, Michelle, Fletcher, Jamie I., Cesare, Anthony J., Hegde, Rashmi S., Pickett, Hilda A.

“…The Eyes Absent proteins (EYA1-4) are a biochemically unique group of tyrosine phosphatases known to be tumour-promoting across a range of cancer types. To…”
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ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway by Yang, Sile F., Nelson, Christopher B., Wells, Jadon K., Fernando, Madushan, Lu, Robert, Allen, Joshua A. M., Malloy, Lisa, Lamm, Noa, Murphy, Vincent J., Mackay, Joel P., Deans, Andrew J., Cesare, Anthony J., Sobinoff, Alexander P., Pickett, Hilda A.

“…The ATR-CHK1 DNA damage response pathway becomes activated by the exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during DNA…”
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Telomeric DNA in ALT Cells Is Characterized by Free Telomeric Circles and Heterogeneous t-Loops by Cesare, Anthony J., Griffith, Jack D.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Telomere uncapping and alternative lengthening of telomeres by Cesare, Anthony J., Reddel, Roger R.

“…A substantial number of human tumors utilize a telomerase-independent telomere length maintenance mechanism referred to as alternative lengthening of telomeres…”
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A Survey of Essential Genome Stability Genes Reveals That Replication Stress Mitigation Is Critical for Peri-Implantation Embryogenesis by Kafer, Georgia R, Cesare, Anthony J

“…Murine development demands that pluripotent epiblast stem cells in the peri-implantation embryo increase from approximately 120 to 14,000 cells between…”
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Disruption of Telomere Maintenance by Depletion of the MRE11/RAD50/NBS1 Complex in Cells That Use Alternative Lengthening of Telomeres by Zhong, Ze-Huai, Jiang, Wei-Qin, Cesare, Anthony J., Neumann, Axel A., Wadhwa, Renu, Reddel, Roger R.

“…Immortalized human cells are able to maintain their telomeres by telomerase or by a recombination-mediated DNA replication mechanism known as alternative…”
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Chromatin mobility and relocation in DNA repair by Lamm, Noa, Rogers, Samuel, Cesare, Anthony J.

“…The nucleus is a dynamic environment containing chromatin, membraneless organelles, and specialized molecular structures at the nuclear membrane. Within the…”
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Termination Factor-Mediated DNA Loop between Termination and Initiation Sites Drives Mitochondrial rRNA Synthesis by Martin, Miguel, Cho, Jaehyoung, Cesare, Anthony J., Griffith, Jack D., Attardi, Giuseppe

“…The human mitochondrial transcription termination factor mTERF plays a central role in the control of heavy-strand rDNA transcription by promoting initiation,…”
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Distinct modes of telomere synthesis and extension contribute to Alternative Lengthening of Telomeres by Lu, Robert, Nelson, Christopher B., Rogers, Samuel, Cesare, Anthony J., Sobinoff, Alexander P., Pickett, Hilda A.

“…Alternative lengthening of telomeres (ALT) is a homology-directed repair mechanism that becomes activated in a subset of cancers to maintain telomere length…”
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Loading of the Human 9-1-1 Checkpoint Complex onto DNA by the Checkpoint Clamp Loader hRad17-Replication Factor C Complex in vitro by Bermudez, Vladimir P., Lindsey-Boltz, Laura A., Cesare, Anthony J., Maniwa, Yoshimasa, Griffith, Jack D., Hurwitz, Jerard, Sancar, Aziz

“…The human DNA damage sensors, Rad17-replication factor C (Rad17-RFC) and the Rad9-Rad1-Hus1 (9-1-1) checkpoint complex, are thought to be involved in the early…”
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