Search Results - "Cesana, Marcella"

A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA by Cesana, Marcella, Cacchiarelli, Davide, Legnini, Ivano, Santini, Tiziana, Sthandier, Olga, Chinappi, Mauro, Tramontano, Anna, Bozzoni, Irene

“…Recently, a new regulatory circuitry has been identified in which RNAs can crosstalk with each other by competing for shared microRNAs. Such competing…”
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EGR1 drives cell proliferation by directly stimulating TFEB transcription in response to starvation by Cesana, Marcella, Tufano, Gennaro, Panariello, Francesco, Zampelli, Nicolina, Ambrosio, Susanna, De Cegli, Rossella, Mutarelli, Margherita, Vaccaro, Lorenzo, Ziller, Micheal J, Cacchiarelli, Davide, Medina, Diego L, Ballabio, Andrea

“…The stress-responsive transcription factor EB (TFEB) is a master controller of lysosomal biogenesis and autophagy and plays a major role in several…”
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Deciphering the rules of ceRNA networks by Cesana, Marcella, Daley, George Q.

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Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma by Powers, John T., Tsanov, Kaloyan M., Pearson, Daniel S., Roels, Frederik, Spina, Catherine S., Ebright, Richard, Seligson, Marc, de Soysa, Yvanka, Cahan, Patrick, Theißen, Jessica, Tu, Ho-Chou, Han, Areum, Kurek, Kyle C., LaPier, Grace S., Osborne, Jihan K., Ross, Samantha J., Cesana, Marcella, Collins, James J., Berthold, Frank, Daley, George Q.

“…Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN . MYCN is itself a target of let-7 , a tumour suppressor family of microRNAs…”
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Regulation of embryonic haematopoietic multipotency by EZH1 by Vo, Linda T., Kinney, Melissa A., Liu, Xin, Zhang, Yuannyu, Barragan, Jessica, Sousa, Patricia M., Jha, Deepak K., Han, Areum, Cesana, Marcella, Shao, Zhen, North, Trista E., Orkin, Stuart H., Doulatov, Sergei, Xu, Jian, Daley, George Q.

“…The production of haematopoietic stem cells is repressed during early mammalian embryogenesis by an epigenetic mechanism that involves the action of the…”
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MicroRNAs Involved in Molecular Circuitries Relevant for the Duchenne Muscular Dystrophy Pathogenesis Are Controlled by the Dystrophin/nNOS Pathway by Cacchiarelli, Davide, Martone, Julie, Girardi, Erika, Cesana, Marcella, Incitti, Tania, Morlando, Mariangela, Nicoletti, Carmine, Santini, Tiziana, Sthandier, Olga, Barberi, Laura, Auricchio, Alberto, Musarò, Antonio, Bozzoni, Irene

“…In Duchenne muscular dystrophy (DMD) the absence of dystrophin at the sarcolemma delocalizes and downregulates nitric oxide synthase (nNOS); this alters…”
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miR-31 modulates dystrophin expression: new implications for Duchenne muscular dystrophy therapy by Cacchiarelli, Davide, Incitti, Tania, Martone, Julie, Cesana, Marcella, Cazzella, Valentina, Santini, Tiziana, Sthandier, Olga, Bozzoni, Irene

“…Duchenne muscular dystrophy (DMD)—which is caused by mutations in the dystrophin gene—is one of the most severe myopathies. Among therapeutic strategies, exon…”
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A case of T-cell acute lymphoblastic leukemia in retroviral gene therapy for ADA-SCID by Cesana, Daniela, Cicalese, Maria Pia, Calabria, Andrea, Merli, Pietro, Caruso, Roberta, Volpin, Monica, Rudilosso, Laura, Migliavacca, Maddalena, Barzaghi, Federica, Fossati, Claudia, Gazzo, Francesco, Pizzi, Simone, Ciolfi, Andrea, Bruselles, Alessandro, Tucci, Francesca, Spinozzi, Giulio, Pais, Giulia, Benedicenti, Fabrizio, Barcella, Matteo, Merelli, Ivan, Gallina, Pierangela, Giannelli, Stefania, Dionisio, Francesca, Scala, Serena, Casiraghi, Miriam, Strocchio, Luisa, Vinti, Luciana, Pacillo, Lucia, Draghi, Eleonora, Cesana, Marcella, Riccardo, Sara, Colantuono, Chiara, Six, Emmanuelle, Cavazzana, Marina, Carlucci, Filippo, Schmidt, Manfred, Cancrini, Caterina, Ciceri, Fabio, Vago, Luca, Cacchiarelli, Davide, Gentner, Bernhard, Naldini, Luigi, Tartaglia, Marco, Montini, Eugenio, Locatelli, Franco, Aiuti, Alessandro

“…Hematopoietic stem cell gene therapy (GT) using a γ-retroviral vector (γ-RV) is an effective treatment for Severe Combined Immunodeficiency due to Adenosine…”
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A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development by Cesana, Marcella, Guo, Michael H., Cacchiarelli, Davide, Wahlster, Lara, Barragan, Jessica, Doulatov, Sergei, Vo, Linda T., Salvatori, Beatrice, Trapnell, Cole, Clement, Kendell, Cahan, Patrick, Tsanov, Kaloyan M., Sousa, Patricia M., Tazon-Vega, Barbara, Bolondi, Adriano, Giorgi, Federico M., Califano, Andrea, Rinn, John L., Meissner, Alexander, Hirschhorn, Joel N., Daley, George Q.

“…While gene expression dynamics have been extensively cataloged during hematopoietic differentiation in the adult, less is known about transcriptome diversity…”
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TFEB Modulates p21/WAF1/CIP1 during the DNA Damage Response by Pisonero-Vaquero, Sandra, Soldati, Chiara, Cesana, Marcella, Ballabio, Andrea, Medina, Diego Luis

“…The MiT/TFE family of transcription factors (MITF, TFE3, and TFEB), which control transcriptional programs for autophagy and lysosome biogenesis have emerged…”
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MET Exon 14 Skipping: A Case Study for the Detection of Genetic Variants in Cancer Driver Genes by Deep Learning by Nosi, Vladimir, Luca, Alessandrì, Milan, Melissa, Arigoni, Maddalena, Benvenuti, Silvia, Cacchiarelli, Davide, Cesana, Marcella, Riccardo, Sara, Di Filippo, Lucio, Cordero, Francesca, Beccuti, Marco, Comoglio, Paolo M, Calogero, Raffaele A

“…Disruption of alternative splicing (AS) is frequently observed in cancer and might represent an important signature for tumor progression and therapy. Exon…”
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The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming by Unternaehrer, Juli J., Zhao, Rui, Kim, Kitai, Cesana, Marcella, Powers, John T., Ratanasirintrawoot, Sutheera, Onder, Tamer, Shibue, Tsukasa, Weinberg, Robert A., Daley, George Q.

“…Reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs) entails a mesenchymal to epithelial transition (MET). While attempting to dissect the…”
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Transcriptional and Chromatin Dynamics of Muscle Regeneration after Severe Trauma by Aguilar, Carlos A., Pop, Ramona, Shcherbina, Anna, Watts, Alain, Matheny, Ronald W., Cacchiarelli, Davide, Han, Woojin M., Shin, Eunjung, Nakhai, Shadi A., Jang, Young C., Carrigan, Christopher T., Gifford, Casey A., Kottke, Melissa A., Cesana, Marcella, Lee, Jackson, Urso, Maria L., Meissner, Alexander

“…Following injury, adult skeletal muscle undergoes a well-coordinated sequence of molecular and physiological events to promote repair and regeneration…”
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A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome by Napolitano, Gennaro, Di Malta, Chiara, Esposito, Alessandra, de Araujo, Mariana E. G., Pece, Salvatore, Bertalot, Giovanni, Matarese, Maria, Benedetti, Valerio, Zampelli, Angela, Stasyk, Taras, Siciliano, Diletta, Venuta, Alessandro, Cesana, Marcella, Vilardo, Claudia, Nusco, Edoardo, Monfregola, Jlenia, Calcagnì, Alessia, Di Fiore, Pier Paolo, Huber, Lukas A., Ballabio, Andrea

“…The mechanistic target of rapamycin complex 1 (mTORC1) is a key metabolic hub that controls the cellular response to environmental cues by exerting its kinase…”
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MiT/TFE factors control ER‐phagy via transcriptional regulation of FAM134B by Cinque, Laura, De Leonibus, Chiara, Iavazzo, Maria, Krahmer, Natalie, Intartaglia, Daniela, Salierno, Francesco Giuseppe, De Cegli, Rossella, Di Malta, Chiara, Svelto, Maria, Lanzara, Carmela, Maddaluno, Marianna, Wanderlingh, Luca Giorgio, Huebner, Antje K, Cesana, Marcella, Bonn, Florian, Polishchuk, Elena, Hübner, Christian A, Conte, Ivan, Dikic, Ivan, Mann, Matthias, Ballabio, Andrea, Sacco, Francesca, Grumati, Paolo, Settembre, Carmine

“…Lysosomal degradation of the endoplasmic reticulum (ER) via autophagy (ER‐phagy) is emerging as a critical regulator of cell homeostasis and function. The…”
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Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency by Cacchiarelli, Davide, Trapnell, Cole, Ziller, Michael J., Soumillon, Magali, Cesana, Marcella, Karnik, Rahul, Donaghey, Julie, Smith, Zachary D., Ratanasirintrawoot, Sutheera, Zhang, Xiaolan, Ho Sui, Shannan J., Wu, Zhaoting, Akopian, Veronika, Gifford, Casey A., Doench, John, Rinn, John L., Daley, George Q., Meissner, Alexander, Lander, Eric S., Mikkelsen, Tarjei S.

“…Induced pluripotency is a promising avenue for disease modeling and therapy, but the molecular principles underlying this process, particularly in human cells,…”
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Esrrb guides naive pluripotent cells through the formative transcriptional programme by Carbognin, Elena, Carlini, Valentina, Panariello, Francesco, Chieregato, Martina, Guerzoni, Elena, Benvegnù, Davide, Perrera, Valentina, Malucelli, Cristina, Cesana, Marcella, Grimaldi, Antonio, Mutarelli, Margherita, Carissimo, Annamaria, Tannenbaum, Eitan, Kugler, Hillel, Hackett, Jamie A., Cacchiarelli, Davide, Martello, Graziano

“…During embryonic development, naive pluripotent epiblast cells transit to a formative state. The formative epiblast cells form a polarized epithelium, exhibit…”
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The deubiquitinating enzyme Usp14 controls ciliogenesis and Hedgehog signaling by Massa, Filomena, Tammaro, Roberta, Prado, Miguel A, Cesana, Marcella, Lee, Byung-Hoon, Finley, Daniel, Franco, Brunella, Morleo, Manuela

“…Abstract Primary cilia are hair-like organelles that play crucial roles in vertebrate development, organogenesis and when dysfunctional result in pleiotropic…”
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TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression by Pasquier, Adrien, Pastore, Nunzia, D'Orsi, Luca, Colonna, Rita, Esposito, Alessandra, Maffia, Veronica, De Cegli, Rossella, Mutarelli, Margherita, Ambrosio, Susanna, Tufano, Gennaro, Grimaldi, Antonio, Cesana, Marcella, Cacchiarelli, Davide, Delalleau, Nathalie, Napolitano, Gennaro, Ballabio, Andrea

“…To fulfill their function, pancreatic beta cells require precise nutrient‐sensing mechanisms that control insulin production. Transcription factor EB (TFEB)…”
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TFEB controls syncytiotrophoblast formation and hormone production in placenta by Cesana, Marcella, Tufano, Gennaro, Panariello, Francesco, Zampelli, Nicolina, Soldati, Chiara, Mutarelli, Margherita, Montefusco, Sandro, Grieco, Giuseppina, Sepe, Lucia Vittoria, Rossi, Barbara, Nusco, Edoardo, Rossignoli, Giada, Panebianco, Giorgia, Merciai, Fabrizio, Salviati, Emanuela, Sommella, Eduardo Maria, Campiglia, Pietro, Martello, Graziano, Cacchiarelli, Davide, Medina, Diego Luis, Ballabio, Andrea

“…TFEB, a bHLH-leucine zipper transcription factor belonging to the MiT/TFE family, globally modulates cell metabolism by regulating autophagy and lysosomal…”
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