Search Results - "Cerutti, P A"

Oxy-radicals and cancer by Cerutti, P A

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Prooxidant States and Tumor Promotion by Cerutti, Peter A.

“…There is convincing evidence that cellular prooxidant states--that is, increased concentrations of active oxygen and organic peroxides and radicals--can…”
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Oxidant stress and carcinogenesis by Cerutti, P A

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Mechanism of c-fos induction by active oxygen by AMSTAD, P. A, KRUPITZA, G, CERUTTI, P. A

“…We have compared the mechanisms of the transcriptional induction of c-fos in mouse epidermal cells JB6 (clone 30) by an extracellular burst of active oxygen of…”
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Clastogenic Action of Hydroperoxy-5,8,11,13-icosatetraenoic Acids on the Mouse Embryo Fibroblasts C3H/10T1/2 by Ochi, Takafumi, Cerutti, Peter A.

“…Phorbol 12-myristate 13-acetate induces the release of a low molecular weight clastogenic factor from monocytes. Hydroperoxy-5,8,11,13-icosatetraenoic acids…”
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Genotypic Analysis of Mutations in Taq I Restriction Recognition Sites by Restriction Fragment Length Polymorphism/Polymerase Chain Reaction by Sandy, Martha S., Chiocca, Susanna M., Cerutti, Peter A.

“…Point mutations in somatic cells play a role in the etiology of several classes of human pathologies. Experimental procedures are required that allow the…”
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Genotypic analysis of N-ethyl-N-nitrosourea-induced mutations by Taq I restriction fragment length polymorphism/polymerase chain reaction in the c-H-ras1 gene by CHIOCCA, S. M, SANDY, M. S, CERUTTI, P. A

“…In genotypic mutation analysis DNA sequence changes are determined without the in vivo or in vitro selection of phenotypically altered cells. We have studied…”
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Response modification creates promotability in multistage carcinogenesis by Cerutti, P A

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Mechanism of induction of c-fos by ultraviolet B (290-320 nm) in mouse JB6 epidermal cells by GIRISH SHAH, GHOSH, R, AMSTAD, P. A, CERUTTI, P. A

“…The UVB (290-320 nm) portion of the solar spectrum possesses the highest activity for the induction of skin cancer and has the capacity to stimulate epidermal…”
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Tumor Promoter Phorbol 12-myristate 13-acetate Induces a Clastogenic Factor in Human Lymphocytes by Emerit, Ingrid, Cerutti, Peter A.

“…The mechanism of the clastogenic action--i.e., the ability to induce chromosomal aberrations--of the tumor promoter phorbol 12-myristate 13-acetate (PMA) was…”
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DNA of human Raji target cells is damaged upon lymphocyte-mediated lysis by Gromkowski, SH, Brown, TC, Cerutti, PA, Cerottini, JC

“…Human Raji target cells DNA is degraded by the introduction of single-strand breaks (alkali-sensitive sites) upon lymphocyte-mediated lysis. This type of DNA…”
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Preferential repair of N-acetoxy-acetylaminofluorene lesions in the nuclease-hypersensitive region of simian virus 40 by Brown, T C, Beard, P, Cerutti, P A

“…We exposed simian virus 40-infected CV-1 monkey cells to the carcinogen N-acetoxy-acetylaminofluorene and monitored the removal of lesions from cellular DNA…”
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c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy by BOUKAMP, P, STANBRIDGE, E. J, YIN FOO, D, CERUTTI, P. A, FUSENIG, N. E

“…Spontaneously immortalized human skin keratinocytes (HaCaT) were transfected with the c-Ha-ras (EJ) oncogene via a plasmid construct which also contained the…”
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Mechanisms of action of oxidant carcinogens by Cerutti, P A

“…Oxidants can act at multiple stages of carcinogenesis. While they cause genetic damage and are cytotoxic, they also activate cellular pathways which alter gene…”
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Formation of products of the 5,6-dihydroxydihydrothymine type by ultraviolet light in HeLa cells by Hariharan, P. V, Cerutti, P. A

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Excision Repair of Benzo[a]pyrene-deoxyguanosine Adducts in baby Hamster Kidney 21/C13 Cells and in Secondary Mouse Embryo Fibroblasts C57BL/6J by Shinohara, Kunio, Cerutti, Peter A.

“…The formation and excision of benzo[a]pyrene-deoxyguanosine adducts in metabolizing baby hamster kidney cells (21/C13) and secondary mouse embryo fibroblasts…”
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Differential effects of glutathione depletion and metallothionein induction on the induction of DNA single-strand breaks and cytotoxicity by tert-butyl hydroperoxide in cultured mammalian cells by Ochi, T, Cerutti, P A

“…Induction of DNA single-strand breaks (ssb), their resealing and cytotoxicity by tert-butyl hydroperoxide (t-BuOOH) were investigated in cultured Chinese…”
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Inflammation and oxidative stress in carcinogenesis by Cerutti, P A, Trump, B F

“…Oxidants, which are generated by multiple pathways in mammalian organisms, may be natural carcinogens and contribute to several stages of malignant…”
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Molecular mechanisms involved in T cell activation. III. The role of extracellular calcium in antigen-induced lymphokine production and interleukin 2-induced proliferation of cloned cytotoxic T lymphocytes by Harris, DT, Kozumbo, WJ, Testa, JE, Cerutti, PA, Cerottini, JC

“…The role that extracellular calcium plays in activating resting cloned cytotoxic T lymphocytes (CTL) to proliferate and to produce lymphokines was examined. In…”
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Ultraviolet radiation inactivates SV40 by disrupting at least four genetic functions by Brown, T.C., Cerutti, P.A.

“…We have examined the relative sensitivities of different genetic functions to damage induced by u.v. light. For this purpose we have introduced defined amounts…”
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