Search Results - "Cerullo, Domenico"

SARS-CoV-2 spike protein induces lung endothelial cell dysfunction and thrombo-inflammation depending on the C3a/C3a receptor signalling by Perico, Luca, Morigi, Marina, Pezzotta, Anna, Locatelli, Monica, Imberti, Barbara, Corna, Daniela, Cerullo, Domenico, Benigni, Ariela, Remuzzi, Giuseppe

“…The spike protein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can interact with endothelial cells. However, no studies demonstrated the…”
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Sirtuin 3 Deficiency Aggravates Kidney Disease in Response to High-Fat Diet through Lipotoxicity-Induced Mitochondrial Damage by Locatelli, Monica, Macconi, Daniela, Corna, Daniela, Cerullo, Domenico, Rottoli, Daniela, Remuzzi, Giuseppe, Benigni, Ariela, Zoja, Carlamaria

“…Sirtuin 3 (SIRT3) is the primary mitochondrial deacetylase that controls the antioxidant pathway and energy metabolism. We previously found that renal Sirt3…”
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SGLT2 inhibitor dapagliflozin limits podocyte damage in proteinuric nondiabetic nephropathy by Cassis, Paola, Locatelli, Monica, Cerullo, Domenico, Corna, Daniela, Buelli, Simona, Zanchi, Cristina, Villa, Sebastian, Morigi, Marina, Remuzzi, Giuseppe, Benigni, Ariela, Zoja, Carlamaria

“…Sodium-glucose cotransporter 2 (SGLT2) inhibitors have pleiotropic properties beyond blood glucose-lowering effects and modify important nonglycemic pathways,…”
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Endothelial Glycocalyx of Peritubular Capillaries in Experimental Diabetic Nephropathy: A Target of ACE Inhibitor-Induced Kidney Microvascular Protection by Locatelli, Monica, Rottoli, Daniela, Mahmoud, Rayan, Abbate, Mauro, Corna, Daniela, Cerullo, Domenico, Tomasoni, Susanna, Remuzzi, Giuseppe, Zoja, Carlamaria, Benigni, Ariela, Macconi, Daniela

“…Peritubular capillary rarefaction is a recurrent aspect of progressive nephropathies. We previously found that peritubular capillary density was reduced in…”
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Bi-specific autoantigen-T cell engagers as targeted immunotherapy for autoreactive B cell depletion in autoimmune diseases by Perico, Luca, Casiraghi, Federica, Sônego, Fabiane, Todeschini, Marta, Corna, Daniela, Cerullo, Domenico, Pezzotta, Anna, Isnard-Petit, Patricia, Faravelli, Silvia, Forneris, Federico, Thiam, Kader, Benigni, Ariela, Remuzzi, Giuseppe

“…In autoimmune diseases, autoreactive B cells comprise only the 0.1-0.5% of total circulating B cells. However, current first-line treatments rely on…”
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Protective Effects of Human Nonrenal and Renal Stromal Cells and Their Conditioned Media in a Rat Model of Chronic Kidney Disease by Imberti, Barbara, Cerullo, Domenico, Corna, Daniela, Rota, Cinzia, Locatelli, Monica, Pezzotta, Anna, Introna, Martino, Capelli, Chiara, Carminati, Claudia Elisa, Rabelink, Ton J., Leuning, Danielle G., Zoja, Carlamaria, Morigi, Marina, Remuzzi, Giuseppe, Benigni, Ariela, Luyckx, Valerie

“…Mesenchymal stromal cells (MSCs) are emerging as a novel therapeutic option for limiting chronic kidney disease progression. Conditioned medium (CM) containing…”
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Add-On Cyclic Angiotensin-(1-7) with Cyclophosphamide Arrests Progressive Kidney Disease in Rats with ANCA Associated Glomerulonephritis by Cerullo, Domenico, Rottoli, Daniela, Corna, Daniela, Abbate, Mauro, Benigni, Ariela, Remuzzi, Giuseppe, Zoja, Carlamaria

“…Rapidly progressive crescentic glomerulonephritis associated with anti-neutrophil cytoplasmic antibodies (ANCA-GN) is a major cause of renal failure. Current…”
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Therapeutic potential of stromal cells of non-renal or renal origin in experimental chronic kidney disease by Rota, Cinzia, Morigi, Marina, Cerullo, Domenico, Introna, Martino, Colpani, Ornella, Corna, Daniela, Capelli, Chiara, Rabelink, Ton J, Leuning, Danielle G, Rottoli, Daniela, Benigni, Ariela, Zoja, Carlamaria, Remuzzi, Giuseppe

“…Mesenchymal stromal cell (MSC)-based therapy is a promising strategy for preventing the progression of chronic kidney disease (CKD), with the potential to…”
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Human iPSC-derived neural crest stem cells can produce EPO and induce erythropoiesis in anemic mice by Brizi, Valerio, Buttò, Sara, Cerullo, Domenico, Michele Lavecchia, Angelo, Rodrigues-Diez, Raquel, Novelli, Rubina, Corna, Daniela, Benigni, Ariela, Remuzzi, Giuseppe, Xinaris, Christodoulos

“…•Development of a novel protocol for the differentiation of Human iPSC into NCCs.•Human NCCs produce EPO in response to hypoxia and induce erythropoiesis in…”
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Thyroid Hormone and Heart Failure: Charting Known Pathways for Cardiac Repair/Regeneration by Mantzouratou, Polyxeni, Malaxianaki, Eleftheria, Cerullo, Domenico, Lavecchia, Angelo Michele, Pantos, Constantinos, Xinaris, Christodoulos, Mourouzis, Iordanis

“…Heart failure affects more than 64 million people worldwide, having a serious impact on their survival and quality of life. Exploring its pathophysiology and…”
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Thyroid hormone treatment counteracts cellular phenotypical remodeling in diabetic organs by Lavecchia, Angelo M., Mantzouratou, Polyxeni, Cerullo, Domenico, Locatelli, Monica, Conti, Sara, Tironi, Matteo, Sangalli, Fabio, Corna, Daniela, Zoja, Carlamaria, Remuzzi, Giuseppe, Xinaris, Christodoulos

“…Diabetes mellitus and alterations in thyroid hormone (TH) signaling are closely linked. Though the role of TH signaling in cell differentiation and growth is…”
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Shiga Toxin 2 Triggers C3a-Dependent Glomerular and Tubular Injury through Mitochondrial Dysfunction in Hemolytic Uremic Syndrome by Buelli, Simona, Locatelli, Monica, Carminati, Claudia Elisa, Corna, Daniela, Cerullo, Domenico, Imberti, Barbara, Perico, Luca, Brigotti, Maurizio, Abbate, Mauro, Zoja, Carlamaria, Benigni, Ariela, Remuzzi, Giuseppe, Morigi, Marina

“…Shiga toxin (Stx)-producing is the predominant offending agent of post-diarrheal hemolytic uremic syndrome (HUS), a rare disorder of microvascular thrombosis…”
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Automatic cyst and kidney segmentation in autosomal dominant polycystic kidney disease: Comparison of U-Net based methods by Rombolotti, Maria, Sangalli, Fabio, Cerullo, Domenico, Remuzzi, Andrea, Lanzarone, Ettore

“…Autosomal Dominant Polycystic Kidney Disease is a genetic disease that causes uncontrolled growth of fluid-filled cysts in the kidney. Kidney enlargement…”
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Empagliflozin protects glomerular endothelial cell architecture in experimental diabetes through the VEGF‐A/caveolin‐1/PV‐1 signaling pathway by Locatelli, Monica, Zoja, Carlamaria, Conti, Sara, Cerullo, Domenico, Corna, Daniela, Rottoli, Daniela, Zanchi, Cristina, Tomasoni, Susanna, Remuzzi, Giuseppe, Benigni, Ariela

“…In addition to having blood glucose‐lowering effects, inhibitors of sodium glucose cotransporter 2 (SGLT2) afford renoprotection in diabetes. We sought to…”
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339 Thyroid hormone levels critically contribute to ADPKD progression by Lavecchia, Angelo Michele, Trillini, Matias, Cerullo, Domenico, Petracca, Benedetta, Brizi, Valerio, Buttò, Sara, Villa, Alessandro, Peracchi, Tobia, Corna, Daniela, Rubis, Nadia, Remuzzi, Giuseppe, Xinaris, Christodoulos

“…Abstract Background and Aims Thyroid hormone (TH) signaling plays a crucial role in the regulation of the cell differentiation state, cell cycle and metabolism…”
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Therapeutic Small Interfering RNA Targeting Complement C3 in a Mouse Model of C3 Glomerulopathy by Zanchi, Cristina, Locatelli, Monica, Cerullo, Domenico, Aumiller, Verena, Corna, Daniela, Rottoli, Daniela, Eisermann, Mona, Donadelli, Roberta, Mousavi, Mansoureh, Noris, Marina, Remuzzi, Giuseppe, Benigni, Ariela, Zoja, Carlamaria

“…Alternative pathway complement dysregulation with abnormal glomerular C3 deposits and glomerular damage is a key mechanism of pathology in C3 glomerulopathy…”
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Efficacy of GalNAc C3 siRNAs in factor H-deficient mice with C3 glomerulopathy by Zanchi, Cristina, Locatelli, Monica, Cerullo, Domenico, Aumiller, Verena, Corna, Daniela, Rottoli, Daniela, Schubert, Steffen, Noris, Marina, Tomasoni, Susanna, Remuzzi, Giuseppe, Zoja, Carlamaria, Benigni, Ariela

“…Complement alternative pathway (AP) dysregulation drives C3 glomerulopathy (C3G), a rare renal disorder characterized by glomerular C3 deposition and…”
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Liver factor B silencing to cure C3 glomerulopathy: Evidence from a mouse model of complement dysregulation by Zanchi, Cristina, Locatelli, Monica, Corna, Daniela, Cerullo, Domenico, Fishilevich, Elane, Desai, Dhruv, Rottoli, Daniela, Donadelli, Roberta, Noris, Marina, Zoja, Carlamaria, Remuzzi, Giuseppe, Benigni, Ariela

“…Uncontrolled activation of the alternative pathway (AP) of complement, due to genetic and/or acquired defects, plays a primary pathogenetic role in C3…”
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Characterization of a Rat Model of Myeloperoxidase-Anti-Neutrophil Cytoplasmic Antibody-Associated Crescentic Glomerulonephritis by Cerullo, Domenico, Rottoli, Daniela, Corna, Daniela, Rizzo, Paola, Abbate, Mauro, Macconi, Daniela, Benigni, Ariela, Remuzzi, Giuseppe, Zoja, Carlamaria

“…Necrotizing crescentic glomerulonephritis (GN) associated with anti-neutrophil cytoplasmic antibodies (ANCA) against myeloperoxidase (MPO) is a devastating…”
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ADAMTS13 Deficiency Shortens the Life Span of Mice With Experimental Diabetes by Cassis, Paola, Cerullo, Domenico, Zanchi, Cristina, Corna, Daniela, Lionetti, Vincenzo, Giordano, Fabrizio, Novelli, Rubina, Conti, Sara, Casieri, Valentina, Matteucci, Marco, Locatelli, Monica, Taraboletti, Giulia, Villa, Sebastian, Gastoldi, Sara, Remuzzi, Giuseppe, Benigni, Ariela, Zoja, Carlamaria

“…In patients with diabetes, impaired activity of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13), the plasma…”
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