Search Results - "Cerottini, JC"

Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909 by Speiser, Daniel E, Liénard, Danielle, Rufer, Nathalie, Rubio-Godoy, Verena, Rimoldi, Donata, Lejeune, Ferdy, Krieg, Arthur M, Cerottini, Jean-Charles, Romero, Pedro

“…The induction of potent CD8+ T cell responses by vaccines to fight microbes or tumors remains a major challenge, as many candidates for human vaccines have…”
Get full text

Effector function of human tumor-specific CD8 T cells in melanoma lesions: A state of local functional tolerance by ZIPPELIUS, Alfred, BATARD, Pascal, RUFER, Nathalie, LUBENOW, Norbert, SPEISER, Daniel, CEROTTINI, Jean-Charles, ROMERO, Pedro, PITTET, Mikaël J, RUBIO-GODOY, Verena, BIOLEY, Gilles, LIENARD, Danielle, LEJEUNE, Ferdy, RIMOLDI, Donata, GUILLAUME, Philippe, MEIDENBAUER, Norbert, MACKENSEN, Andreas

“…Although tumor-specific CD8 T-cell responses often develop in cancer patients, they rarely result in tumor eradication. We aimed at studying directly the…”
Get full text

Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions by Rufer, Nathalie, Zippelius, Alfred, Batard, Pascal, Pittet, Mikaël J., Kurth, Isabel, Corthesy, Patricia, Cerottini, Jean-Charles, Leyvraz, Serge, Roosnek, Eddy, Nabholz, Markus, Romero, Pedro

“…After antigenic challenge, naive T lymphocytes enter a program of proliferation and differentiation during the course of which they acquire effector functions…”
Get full text

High frequencies of naive Melan-A/MART-1-specific CD8(+) T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2 individuals by Pittet, M J, Valmori, D, Dunbar, P R, Speiser, D E, Liénard, D, Lejeune, F, Fleischhauer, K, Cerundolo, V, Cerottini, J C, Romero, P

“…Using fluorescent HLA-A*0201 tetramers containing the immunodominant Melan-A/MART-1 (Melan-A) tumor-associated antigen (Ag), we previously observed that…”
Get full text

Lack of BRAF mutations in uveal melanoma by RIMOLDI, Donata, SALVI, Suzanne, LIENARD, Danielle, LEJEUNE, Ferdy J, SPEISER, Daniel, ZOGRAFOS, Leonidas, CEROTTINI, Jean-Charles

“…RAF proteins are serine/threonine kinases that mediate cellular responses to growth signals by activating the mitogen-activated protein kinase pathway…”
Get full text

Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes by Romero, P, Dunbar, P R, Valmori, D, Pittet, M, Ogg, G S, Rimoldi, D, Chen, J L, Liénard, D, Cerottini, J C, Cerundolo, V

“…Characterization of cytolytic T lymphocyte (CTL) responses to tumor antigens has been impeded by a lack of direct assays of CTL activity. We have synthesized…”
Get full text

Cross-priming of naive CD8 T cells against melanoma antigens using dendritic cells loaded with killed allogeneic melanoma cells by Berard, F, Blanco, P, Davoust, J, Neidhart-Berard, E M, Nouri-Shirazi, M, Taquet, N, Rimoldi, D, Cerottini, J C, Banchereau, J, Palucka, A K

“…The goal of tumor immunotherapy is to elicit immune responses against autologous tumors. It would be highly desirable that such responses include multiple T…”
Get full text

Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells by Morel, S, Lévy, F, Burlet-Schiltz, O, Brasseur, F, Probst-Kepper, M, Peitrequin, A L, Monsarrat, B, Van Velthoven, R, Cerottini, J C, Boon, T, Gairin, J E, Van den Eynde, B J

“…By stimulating human lymphocytes with an autologous renal carcinoma, we obtained CTL recognizing an antigen derived from a novel, ubiquitous protein. The CTL…”
Get full text

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape by Hahne, M., Rimoldi, D., Schröter, M., Romero, P., Schreier, M., French, L. E., Schneider, P., Bornand, T., Fontana, A., Lienard, D., Cerottini, J. C., Tschopp, J.

“…Malignant melanoma accounts for most of the increasing mortality from skin cancer. Melanoma cells were found to express Fas (also called Apo-1 or CD95) ligand…”
Get full text

Naturally Acquired MAGE-A10- and SSX-2-Specific CD8+ T Cell Responses in Patients with Hepatocellular Carcinoma by Bricard, Gabriel, Bouzourene, Hanifa, Martinet, Olivier, Rimoldi, Donata, Halkic, Nermin, Gillet, Michel, Chaubert, Pascal, MacDonald, H. Robson, Romero, Pedro, Cerottini, Jean-Charles, Speiser, Daniel E

“…Immunotherapy is being proposed to treat patients with hepatocellular carcinoma (HCC). However, more detailed knowledge on tumor Ag expression and specific…”
Get full text

Cutting Edge: Cytolytic Effector Function in Human Circulating CD8+ T Cells Closely Correlates with CD56 Surface Expression by Pittet, Mikael J, Speiser, Daniel E, Valmori, Danila, Cerottini, Jean-Charles, Romero, Pedro

“…Recent data suggest that human effector CD8+ T cells express a distinct CD27-CD45RAhigh (CD57+CD28-CD11ahigh) phenotype. Here, we propose that CTL effector…”
Get full text

Efficient induction of tumor antigen-specific CD8+ memory T cells by recombinant lentivectors by CHAPATTE, Laurence, COLOMBETTI, Sara, CEROTTINI, Jean-Charles, LEVY, Frédéric

“…The success of active cancer immunotherapy entails a robust induction of tumor-reactive effector and memory CD8+ T cells. We compared the in vivo…”
Get full text

Structural Prediction of Peptides Bound to MHC Class I by Fagerberg, Theres, Cerottini, Jean-Charles, Michielin, Olivier

“…An ab initio structure prediction approach adapted to the peptide–major histocompatibility complex (MHC) class I system is presented. Based on structure…”
Get full text

CpG Are Efficient Adjuvants for Specific CTL Induction Against Tumor Antigen-Derived Peptide by Miconnet, Isabelle, Koenig, Sylvain, Speiser, Daniel, Krieg, Arthur, Guillaume, Philippe, Cerottini, Jean-Charles, Romero, Pedro

“…The identification of CTL-defined tumor-associated Ags has allowed the development of new strategies for cancer immunotherapy. To potentiate the CTL responses,…”
Get full text

Enhanced Generation of Specific Tumor-Reactive CTL In Vitro by Selected Melan-A/MART-1 Immunodominant Peptide Analogues by Valmori, Danila, Fonteneau, Jean-Francois, Lizana, Concepcion Maranon, Gervois, Nadine, Lienard, Danielle, Rimoldi, Donata, Jongeneel, Victor, Jotereau, Francine, Cerottini, Jean-Charles, Romero, Pedro

“…The Melan-A/MART-1 gene, which is expressed by normal melanocytes as well as by most fresh melanoma samples and melanoma cell lines, codes for Ags recognized…”
Get full text

OmpA targets dendritic cells, induces their maturation and delivers antigen into the MHC class I presentation pathway by Delneste, Yves, Goetsch, Liliane, Soulas, Caroline, Cerottini, Jean-Charles, Magistrelli, Giovanni, Miconnet, Isabelle, Aubry, Jean-Pierre, Bonnefoy, Jean-Yves, Baussant, Thierry, Renno, Toufic, Herbault, Nathalie, Jeannin, Pascale, Romero, Pedro

“…We analyzed the interaction between a bacterial cell wall protein and dendritic cells (DCs). Outer membrane protein A from Klebsiella pneumoniae (kpOmpA)…”
Get full text

Tumor Antigens Recognized by T Lymphocytes by Boon, Thierry, Cerottini, Jean-Charles, Van den Eynde, Benoit, van der Bruggen, Pierre, Van Pel, Aline

“…Transplantation experiments have demonstrated that most mouse tumors express antigens that can constitute targets for rejection responses mediated by syngeneic…”
Get full text

Monitoring tumor antigen specific T-cell responses in cancer patients and phase I clinical trials of peptide-based vaccination by ROMERO, Pedro, CEROTTINI, Jean-Charles, SPEISER, Daniel E

“…Numerous phase I and II clinical trials testing the safety and immunogenicity of various peptide vaccine formulations based on CTL-defined tumor antigens in…”
Get full text

Molecular control of tissue-specific expression at the mouse TNF locus by Jongeneel, C V, Shakhov, A N, Nedospasov, S A, Cerottini, J C

“…We have examined the patterns of mRNA accumulation and transcription of the tandemly linked genes for tumor necrosis factor (TNF)-beta and TNF-alpha. In spite…”
Get more information

Naturally occurring human lymphocyte antigen-A2 restricted CD8+ T-cell response to the cancer testis antigen NY-ESO-1 in melanoma patients by VALMORI, D, DUTOIT, V, CEROTTINI, J.-C, ROMERO, P, LIENARD, D, RIMOLDI, D, PITTET, M. J, CHAMPAGNE, P, ELLEFSEN, K, SAHIN, U, SPEISER, D, LEJEUNE, F

“…Cancer testis (CT) antigens are particularly interesting candidates for cancer vaccines. However, T-cell reactivity to CT antigens has been detected only…”
Get full text