Search Results - "Cerny, Natacha"
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Trypanocidal Activity of Four Sesquiterpene Lactones Isolated from Asteraceae Species
Published in Molecules (Basel, Switzerland) (25-04-2020)“…The sesquiterpene lactones eupatoriopicrin, estafietin, eupahakonenin B and minimolide have been isolated from Argentinean Astearaceae species and have been…”
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Cruzipain and Its Physiological Inhibitor, Chagasin, as a DNA-Based Therapeutic Vaccine Against Trypanosoma cruzi
Published in Frontiers in immunology (09-10-2020)“…Chagas disease caused by the protozoan parasite is endemic in 21 Latin American countries and the southern United States and now is spreading into several…”
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3
Assessment of sesquiterpene lactones isolated from Mikania plants species for their potential efficacy against Trypanosoma cruzi and Leishmania sp
Published in PLoS neglected tropical diseases (25-09-2017)“…Four sesquiterpene lactones, mikanolide, deoxymikanolide, dihydromikanolide and scandenolide, were isolated by a bioassay-guided fractionation of Mikania…”
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4
Oxonitrogenated Derivatives of Eremophilans and Eudesmans: Antiproliferative and Anti- Trypanosoma cruzi Activity
Published in Molecules (Basel, Switzerland) (10-05-2022)“…Cancer is one of the most important causes of death worldwide. Solid tumors represent the vast majority of cancers (>90%), and the chemotherapeutic agents used…”
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5
Activity of Estafietin and Analogues on Trypanosoma cruzi and Leishmania braziliensis
Published in Molecules (Basel, Switzerland) (28-03-2019)“…Sesquiterpene lactones are naturally occurring compounds mainly found in the Asteraceae family. These types of plant metabolites display a wide range of…”
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Trypanosoma cruzi 80 kDa prolyl oligopeptidase (Tc80) as a novel immunogen for Chagas disease vaccine
Published in PLoS neglected tropical diseases (01-03-2018)“…Chagas disease, also known as American Trypanosomiasis, is a chronic parasitic disease caused by the flagellated protozoan Trypanosoma cruzi that affects about…”
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Mucosal Heterologous Prime/Boost Vaccination Induces Polyfunctional Systemic Immunity, Improving Protection Against Trypanosoma cruzi
Published in Frontiers in immunology (21-02-2020)“…There are several unmet needs in modern immunology. Among them, vaccines against parasitic diseases and chronic infections lead. , the causative agent of…”
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Engineered trivalent immunogen adjuvanted with a STING agonist confers protection against Trypanosoma cruzi infection
Published in npj vaccines (10-04-2017)“…The parasite Trypanosoma cruzi is the causative agent of Chagas disease, a potentially life-threatening infection that represents a major health problem in…”
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Preparation of Sesquiterpene Lactone Derivatives: Cytotoxic Activity and Selectivity of Action
Published in Molecules (Basel, Switzerland) (20-03-2019)“…Cancer is one of the most important causes of death worldwide. Solid tumors represent the great majority of cancers (>90%) and the chemotherapeutic agents used…”
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10
Trypanocidal and Anti-Inflammatory Effects of Three ent -Kaurane Diterpenoids from Gymnocoronis spilanthoides var. subcordata (Asteraceae)
Published in Pharmaceutics (18-03-2024)“…Chagas disease, caused by the protozoan , affects 6-7 million people worldwide. The dichloromethane extract obtained from the aerial parts of var showed…”
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In Vitro, In Vivo, and In Silico Studies of Cumanin Diacetate as a Potential Drug against Trypanosoma cruzi Infection
Published in ACS omega (11-01-2022)“…The sesquiterpene lactones cumanin, helenalin, and hymenin and their semisynthetic derivatives were evaluated against Trypanosoma cruzi epimastigotes. The…”
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12
Chagas disease vaccine design: the search for an efficient Trypanosoma cruzi immune-mediated control
Published in Biochimica et biophysica acta. Molecular basis of disease (01-05-2020)“…Chagas disease is currently endemic to 21 Latin-American countries and has also become a global concern because of globalization and mass migration of…”
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Cytokines expression from altered motor thalamus and behavior deficits following sublethal administration of Shiga toxin 2a involve the induction of the globotriaosylceramide receptor
Published in Toxicon (Oxford) (01-09-2022)“…Encephalopathy associated with hemolytic uremic syndrome is produced by enterohemorrhagic E. coli (EHEC) infection, which releases the virulence factors Shiga…”
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In silico toxicologic profile and in vivo trypanocidal activity of estafietin, a sesquiterpene lactone isolated from Stevia alpina Griseb
Published in Natural product research (01-02-2024)“…Chagas disease is an infection caused by the protozoan affecting 6-8 million people worldwide. Only two drugs are available for its treatment, having a limited…”
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Trypanocidal and Anti-Inflammatory Effects of Three Ient/I-Kaurane Diterpenoids from IGymnocoronis spilanthoides/I var. Isubcordata/I
Published in Pharmaceutics (01-03-2024)“…Chagas disease, caused by the protozoan Trypanosoma cruzi, affects 6–7 million people worldwide. The dichloromethane extract obtained from the aerial parts of…”
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Oral Multicomponent DNA Vaccine Delivered by Attenuated Salmonella Elicited Immunoprotection Against American Trypanosomiasis
Published in The Journal of infectious diseases (01-03-2015)“…We have reported that attenuated Salmonella (S) carrying plasmids encoding the cysteine protease cruzipain (Cz) protects against Trypanosoma cruzi infection…”
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Trypanosoma cruzi 80 kDa prolyl oligopeptidase
Published in PLoS neglected tropical diseases (30-03-2018)“…Background Chagas disease, also known as American Trypanosomiasis, is a chronic parasitic disease caused by the flagellated protozoan Trypanosoma cruzi that…”
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Trypanocidal and leishmanicidal activities of flavonoids isolated from Stevia satureiifolia var. satureiifolia
Published in Pharmaceutical biology (02-10-2016)“…Context Chagas' disease and leishmaniasis produce significant disability and mortality with great social and economic impact. The genus Stevia (Asteraceae) is…”
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Attenuated Salmonella sp. as a DNA Delivery System for Trypanosoma cruzi Antigens
Published in Methods in molecular biology (Clifton, N.J.) (01-01-2016)“…Chagas disease is an important neglected disease affecting thousands of people in the Americas. Novel strategies for prophylactic and therapeutic vaccines…”
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Coadministration of cruzipain and GM-CSF DNAs, a new immunotherapeutic vaccine against Trypanosoma cruzi infection
Published in Human vaccines & immunotherapeutics (01-02-2016)“…Therapeutic vaccine research and development are especially important in Chagas disease considering the characteristics of the chronic infection and the number…”
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