Search Results - "Cerniglia, George"

ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis by Dey, Souvik, Sayers, Carly M, Verginadis, Ioannis I, Lehman, Stacey L, Cheng, Yi, Cerniglia, George J, Tuttle, Stephen W, Feldman, Michael D, Zhang, Paul J L, Fuchs, Serge Y, Diehl, J Alan, Koumenis, Constantinos

“…The integrated stress response (ISR) is a critical mediator of cancer cell survival, and targeting the ISR inhibits tumor progression. Here, we have shown that…”
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Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 by Cerniglia, George J, Karar, Jayashree, Tyagi, Sonia, Christofidou-Solomidou, Melpo, Rengan, Ramesh, Koumenis, Constantinos, Maity, Amit

“…We investigated the effect of 2-methyl-2-{4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl]phenyl} propanenitrile (NVP-BEZ235)…”
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Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy by Cerniglia, George J, Pore, Nabendu, Tsai, Jeff H, Schultz, Susan, Mick, Rosemarie, Choe, Regine, Xing, Xiaoman, Durduran, Turgut, Yodh, Arjun G, Evans, Sydney M, Koch, Cameron J, Hahn, Stephen M, Quon, Harry, Sehgal, Chandra M, Lee, William M F, Maity, Amit

“…Epidermal growth factor receptor (EGFR) inhibitors have shown only modest clinical activity when used as single agents to treat cancers. They decrease tumor…”
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The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation by Cerniglia, George J, Dey, Souvik, Gallagher-Colombo, Shannon M, Daurio, Natalie A, Tuttle, Stephen, Busch, Theresa M, Lin, Alexander, Sun, Ramon, Esipova, Tatiana V, Vinogradov, Sergei A, Denko, Nicholas, Koumenis, Constantinos, Maity, Amit

“…Inhibition of the PI3K/Akt pathway decreases hypoxia within SQ20B human head and neck cancer xenografts. We set out to understand the molecular mechanism…”
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Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia by Karar, Jayashree, Cerniglia, George J., Lindsten, Tullia, Koumenis, Constantinos, Maity, Amit

“…The PI3K/Akt pathway is activated in many cancers; therefore, we investigated NVP-BEZ235, a dual PI3K/mTOR inhibitor. BEZ235 was more potent than either the…”
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ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis by Dey, Souvik, Sayers, Carly M., Verginadis, Ioannis I., Lehman, Stacey L., Cheng, Yi, Cerniglia, George J., Tuttle, Stephen W., Feldman, Michael D., Zhang, Paul J.L., Fuchs, Serge Y., Diehl, J. Alan, Koumenis, Constantinos

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EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms by PORE, Nabendu, ZIBIN JIANG, GUPTA, Anjali, CERNIGLIA, George, KAO, Gary D, MAITY, Amit

“…Epidermal growth factor receptor (EGFR) inhibitors can decrease vascular endothelial growth factor (VEGF) expression and tumor angiogenesis. In the current…”
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Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir by ZIBIN JIANG, PORE, Nabendu, CERNIGLIA, George J, MICK, Rosemarie, GEORGESCU, Maria-Magdelena, BERNHARD, Eric J, HAHN, Stephen M, GUPTA, Anjali K, MAITY, Amit

“…Glioblastomas are malignant brain tumors that are very difficult to cure, even with aggressive therapy consisting of surgery, chemotherapy, and radiation…”
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Agonists of the TRAIL Death Receptor DR5 Sensitize Intestinal Stem Cells to Chemotherapy-Induced Cell Death and Trigger Gastrointestinal Toxicity by Finnberg, Niklas K, Gokare, Prashanth, Navaraj, Arunasalam, Lang Kuhs, Krystle A, Cerniglia, George, Yagita, Hideo, Takeda, Kazuyoshi, Motoyama, Noboru, El-Deiry, Wafik S

“…The combination of TRAIL death receptor agonists and radiochemotherapy to treat advanced cancers continues to be investigated in clinical trials. We previously…”
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Nelfinavir down-regulates hypoxia-Inducible factor 1α and VEGF expression and increases tumor oxygenation : Implications for radiotherapy by PORE, Nabendu, GUPTA, Anjali K, CERNIGLIA, George J, ZIBIN JIANG, BERNHARD, Eric J, EVANS, Sydney M, KOCH, Cameron J, HAHN, Stephen M, MAITY, Amit

“…Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt pathway can increase vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1α (HIF-1α)…”
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The HIV Protease Inhibitor Nelfinavir Downregulates Akt Phosphorylation by Inhibiting Proteasomal Activity and Inducing the Unfolded Protein Response by Gupta, Anjali K., Li, Bin, Cerniglia, George J., Ahmed, Mona S., Hahn, Stephen M., Maity, Amit

“…HIV protease inhibitors (HPIs), which have been used to treat HIV patients since the mid 1990s, have been shown to downregulate the phosphatidylinositol…”
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HIV protease inhibitors block akt signaling and radiosensitize tumor cells both in vitro and in vivo by GUPTA, Anjali K, CERNIGLIA, George J, MICK, Rosemarie, MCKENNA, W. Gillies, MUSCHEL, Ruth J

“…In tumor cells with mutations in epidermal growth factor receptor (SQ20B), H-Ras (T24), or K-Ras (MIAPACA2 and A549), the inhibition of Akt phosphorylation…”
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Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress by Lehman, Stacey L, Cerniglia, George J, Johannes, Gregg J, Ye, Jiangbin, Ryeom, Sandra, Koumenis, Constantinos

“…Multiple transcripts encode for the cell cycle inhibitor p21(Cip1). These transcripts produce identical proteins but differ in their 5' untranslated regions…”
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Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002 by Gupta, Anjali K, Cerniglia, George J, Mick, Rosemarie, Ahmed, Mona S, Bakanauskas, Vincent J, Muschel, Ruth J, McKenna, W Gillies

“…Multiple genetic alterations such as in Ras or EGFR can result in sustained signaling through PI3K. Our previous experiments have shown that resistance to…”
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Local recurrence in head and neck cancer: Relationship to radiation resistance and signal transduction by GUPTA, Anjali K, MCKENNA, W. Gillies, BERNHARD, Eric J, WEBER, Randal S, MUSCHEL, Ruth J, WEBER, Charles N, FELDMAN, Michael D, GOLDSMITH, Jeffrey D, MICK, Rosemarie, MACHTAY, Mitchell, ROSENTHAL, David I, BAKANAUSKAS, Vincent J, CERNIGLIA, George J

“…Locoregional recurrence is the dominant form of treatment failure in head and neck (H&N) cancer. The epidermal growth factor receptor (EGFR) is frequently…”
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Validation and toxicity of PI3K/Akt pathway inhibition by HIV protease inhibitors in humans by P. Plastaras, John, Vapiwala, Neha, S. Ahmed, Mona, Gudonis, Deborah, J. Cerniglia, George, D. Feldman, Michael, Frank, Ian, K. Gupta, Anjali

“…PurposeActivation of the phosphatidylinositol 3-kinase/Akt pathway in tumors leads to radiation resistance, and inhibition of this pathway radiosensitizes…”
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RhoB Is Required to Mediate Apoptosis in Neoplastically Transformed Cells after DNA Damage by Liu, Ai-xue, Cerniglia, George J., Bernhard, Eric J., Prendergast, George C.

“…The effect of neoplastic transformation on the response to genotoxic stress is of significant clinical interest. In this study, we offer genetic evidence that…”
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Inhibition of Centrosome Separation after DNA Damage: A Role for Nek2 by Fletcher, Lynda, Cerniglia, George J., Nigg, Erich A., Yen, Tim J., Muschel, Ruth J.

“…Fletcher, L., Cerniglia, G. J., Nigg, E. A., Yen, T. J. and Muschel, R. J. Inhibition of Centrosome Separation after DNA Damage: A Role for Nek2. Radiat. Res…”
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HIV Protease Inhibitors Decrease VEGF/HIF-1α Expression and Angiogenesis in Glioblastoma Cells by Pore, Nabendu, Gupta, Anjali K., Cerniglia, George J., Maity, Amit

“…Glioblastomas are malignant brain tumors that are rarely curable, even with aggressive therapy (surgery, chemotherapy, radiation). Glioblastomas frequently…”
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Live cell imaging reveals distinct roles in cell cycle regulation for Nek2A and Nek2B by Fletcher, Lynda, Cerniglia, George J., Yen, Tim J., Muschel, Ruth J.

“…Two splice variants of Nek2 kinase, a member of the NIMA-related family, have been identified as Nek2A and Nek2B. Nek2A regulates centrosome disjunction,…”
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