Search Results - "Ceri, H"

Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS by Gibbs, Katherine L., Kalmar, Bernadett, Rhymes, Elena R., Fellows, Alexander D., Ahmed, Mahmood, Whiting, Paul, Davies, Ceri H., Greensmith, Linda, Schiavo, Giampietro

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by the degeneration of upper and lower motor neurons. Defects in axonal…”
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Orexin 2 receptor–selective agonist danavorexton improves narcolepsy phenotype in a mouse model and in human patients by Evans, Rebecca, Kimura, Haruhide, Alexander, Robert, Davies, Ceri H., Faessel, Hélène, Hartman, Deborah S., Ishikawa, Takashi, Ratti, Emiliangelo, Shimizu, Kohei, Suzuki, Motohisa, Tanaka, Shinichiro, Yukitake, Hiroshi, Dauvilliers, Yves, Mignot, Emmanuel

“…Narcolepsy type 1 (NT1) is a sleep disorder caused by a loss of orexinergic neurons. Narcolepsy type 2 (NT2) is heterogeneous; affected individuals typically…”
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Neurological updates: neurological complications of CAR-T therapy by Tallantyre, Emma C., Evans, Nia A., Parry-Jones, Jack, Morgan, Matt P. G., Jones, Ceri H., Ingram, Wendy

“…Chimeric antigen receptor (CAR)-expressing T cells now offer an effective treatment option for people with previously refractory B cell malignancies and are…”
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Anti-adhesion activity of two biosurfactants produced by Bacillus spp. prevents biofilm formation of human bacterial pathogens by Rivardo, F, Turner, R. J, Allegrone, G, Ceri, H, Martinotti, M. G

“…In this work, two biosurfactant-producing strains, Bacillus subtilis and Bacillus licheniformis, have been characterized. Both strains were able to grow at…”
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Evaluating Presence-Absence Models in Ecology: The Need to Account for Prevalence by Manel, Stéphanie, Williams, H. Ceri, Ormerod, S. J.

“…1. Models for predicting the distribution of organisms from environmental data are widespread in ecology and conservation biology. Their performance is…”
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The role of astrocytes in seizure generation: insights from a novel in vitro seizure model based on mitochondrial dysfunction by Chan, Felix, Lax, Nichola Z, Voss, Caroline Marie, Aldana, Blanca Irene, Whyte, Shuna, Jenkins, Alistair, Nicholson, Claire, Nichols, Sophie, Tilley, Elizabeth, Powell, Zoe, Waagepetersen, Helle S, Davies, Ceri H, Turnbull, Doug M, Cunningham, Mark O

“…Many patients with mitochondrial disease have neurological symptoms, including drug-refractory epilepsy. Chan et al. develop an in vitro model of mitochondrial…”
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Strategies to Address Challenges in Neuroscience Drug Discovery and Development by O'Donnell, Patricio, Rosen, Laura, Alexander, Robert, Murthy, Venkatesha, Davies, Ceri H, Ratti, Emiliangelo

“…The paucity of novel drugs for neuropsychiatric indications contrasts with the remarkable recent advances in neuroscience research. We have identified 5…”
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A homozygous loss‐of‐function mutation in PDE2A associated to early‐onset hereditary chorea by Salpietro, Vincenzo, Perez‐Dueñas, Belen, Nakashima, Kosuke, Antonio‐Arce, Victoria, Manole, Andreea, Efthymiou, Stephanie, Vandrovcova, Jana, Bettencourt, Conceicao, Mencacci, Niccolò E., Klein, Christine, Kelly, Michy P., Davies, Ceri H., Kimura, Haruhide, Macaya, Alfons, Houlden, Henry

“…ABSTRACT Background: We investigated a family that presented with an infantile‐onset chorea‐predominant movement disorder, negative for NKX2‐1, ADCY5, and…”
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Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor by Hirano, Kazufumi, Chen, Woei Shin, Chueng, Adeline L W, Dunne, Angela A, Seredenina, Tamara, Filippova, Aleksandra, Ramachandran, Sumitra, Bridges, Angela, Chaudry, Laiq, Pettman, Gary, Allan, Craig, Duncan, Sarah, Lee, Kiew Ching, Lim, Jean, Ma, May Thu, Ong, Agnes B, Ye, Nicole Y, Nasir, Shabina, Mulyanidewi, Sri, Aw, Chiu Cheong, Oon, Pamela P, Liao, Shihua, Li, Dizheng, Johns, Douglas G, Miller, Neil D, Davies, Ceri H, Browne, Edward R, Matsuoka, Yasuji, Chen, Deborah W, Jaquet, Vincent, Rutter, A Richard

“…The NADPH oxidase (NOX) family of enzymes catalyzes the formation of reactive oxygen species (ROS). NOX enzymes not only have a key role in a variety of…”
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Luvadaxistat: A Novel Potent and Selective d-Amino Acid Oxidase Inhibitor Improves Cognitive and Social Deficits in Rodent Models for Schizophrenia by Fradley, Rosa, Goetghebeur, Pascal, Miller, David, Burley, Russell, Almond, Sarah, Gruart i Massó, Agnès, Delgado García, José M., Zhu, Bin, Howley, Eimear, Neill, Jo C., Grayson, Ben, Gaskin, Philip, Carlton, Mark, Gray, Ian, Serrats, Jordi, Davies, Ceri H.

“…N-methyl- d -aspartate (NMDA) receptor hypofunctionality is a well-studied hypothesis for schizophrenia pathophysiology, and daily dosing of the NMDA receptor…”
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Telomere dysfunction and its role in haematological cancer by Jones, Ceri H., Pepper, Chris, Baird, Duncan M.

“…Summary Observations in human tumours, as well as mouse models, have indicated that telomere dysfunction may be a key event driving genomic instability and…”
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The potent M1 receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction by Nathan, Pradeep J., Watson, Jeannette, Lund, Jesper, Davies, Ceri H., Peters, Gary, Dodds, Chris M., Swirski, Bridget, Lawrence, Philip, Bentley, Graham D., O'Neill, Barry V., Robertson, Jon, Watson, Stephen, Jones, Gareth A., Maruff, Paul, Croft, Rodney J., Laruelle, Marc, Bullmore, Edward T.

“…Episodic memory deficits are a core feature of neurodegenerative disorders. Muscarinic M1 receptors play a critical role in modulating learning and memory and…”
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De Novo Mutations in PDE10A Cause Childhood-Onset Chorea with Bilateral Striatal Lesions by Mencacci, Niccolò E., Kamsteeg, Erik-Jan, Nakashima, Kosuke, R’Bibo, Lea, Lynch, David S., Balint, Bettina, Willemsen, Michèl A.A.P., Adams, Matthew E., Wiethoff, Sarah, Suzuki, Kazunori, Davies, Ceri H., Ng, Joanne, Meyer, Esther, Veneziano, Liana, Giunti, Paola, Hughes, Deborah, Raymond, F. Lucy, Carecchio, Miryam, Zorzi, Giovanna, Nardocci, Nardo, Barzaghi, Chiara, Garavaglia, Barbara, Salpietro, Vincenzo, Hardy, John, Pittman, Alan M., Houlden, Henry, Kurian, Manju A., Kimura, Haruhide, Vissers, Lisenka E.L.M., Wood, Nicholas W., Bhatia, Kailash P.

“…Chorea is a hyperkinetic movement disorder resulting from dysfunction of striatal medium spiny neurons (MSNs), which form the main output projections from the…”
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Correction to: Luvadaxistat: A Novel Potent and Selective d-Amino Acid Oxidase Inhibitor Improves Cognitive and Social Deficits in Rodent Models for Schizophrenia by Fradley, Rosa, Goetghebeur, Pascal, Miller, David, Burley, Russell, Almond, Sarah, Gruart i Massó, Agnès, Delgado García, José M., Zhu, Bin, Howley, Eimear, Neill, Jo C., Grayson, Ben, Gaskin, Philip, Carlton, Mark, Gray, Ian, Serrats, Jordi, Davies, Ceri H.

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Emerging strategies to treat the brain, behind its barrier by Little, Wheaton T., Davies, Ceri H.

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A neocortical delta rhythm facilitates reciprocal interlaminar interactions via nested theta rhythms by Carracedo, Lucy M, Kjeldsen, Henrik, Cunnington, Leonie, Jenkins, Alastair, Schofield, Ian, Cunningham, Mark O, Davies, Ceri H, Traub, Roger D, Whittington, Miles A

“…Delta oscillations (1-4 Hz) associate with deep sleep and are implicated in memory consolidation and replay of cortical responses elicited during wake states…”
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Scalable Measurements of Intrinsic Excitability in Human iPS Cell-Derived Excitatory Neurons Using All-Optical Electrophysiology by Williams, Luis A., Joshi, Vaibhav, Murphy, Michael, Ferrante, John, Werley, Christopher A., Brookings, Theodore, McManus, Owen, Grosse, Johannes, Davies, Ceri H., Dempsey, Graham T.

“…Induced pluripotent stem (iPS) cells offer the exciting opportunity for modeling neurological disorders in vitro in the context of a human genetic background…”
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The Calgary Biofilm Device: New Technology for Rapid Determination of Antibiotic Susceptibilities of Bacterial Biofilms by CERI, H, OLSON, M. E, STREMICK, C, READ, R. R, MORCK, D, BURET, A

“…Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Neuronal oscillations: A physiological correlate for targeting mitochondrial dysfunction in neurodegenerative diseases? by Chan, Felix, Lax, Nichola Z., Davies, Ceri H., Turnbull, Douglass M., Cunningham, Mark O.

“…Increasingly in the realm of neurological disorders, particularly those involving neurodegeneration, mitochondrial dysfunction is emerging at the core of their…”
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Cholinergic modulation of hippocampal cells and circuits by Cobb, Stuart R., Davies, Ceri H.

“…Septo-hippocampal cholinergic fibres ramify extensively throughout the hippocampal formation to release acetylcholine upon a diverse range of muscarinic and…”
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