Search Results - "Cercus, Jacques"

Synthesis of new N-aryl oxindoles as intermediates for pharmacologically active compounds by Acemoglu, Murat, Allmendinger, Thomas, Calienni, John, Cercus, Jacques, Loiseleur, Olivier, Sedelmeier, Gottfried H., Xu, David

“…Various new N-aryl oxindoles were synthesized as intermediates for the preparation of pharmacologically active 2-( N-arylamino)-phenylacetic acids. Two novel…”
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The development of a practical synthesis of the potent and selective somatostatin sst3 receptor antagonist [4-(3,4-difluoro-phenyl)-piperazine-1-yl]-{(4S,4aS,8aR)-2[(S)-3-(6-methoxy-pyridin-3-yl)-2-methyl-propyl]-decahydroisoquinoline-4-yl}-methanone (NVP-ACQ090) by Bänziger, Markus, Cercus, Jacques, Hirt, Hans, Laumen, Kurt, Malan, Christophe, Spindler, Felix, Struber, Fritz, Troxler, Thomas

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A Formal Synthesis of (+)-Discodermolide by Loiseleur, Olivier, Koch, Guido, Cercus, Jacques, Schürch, Friedrich

“…Herein, we report the formal synthesis of (+)-discodermolide (1), a promising anticancer agent of sponge origin, in 24 linear steps, with 35 steps in total…”
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Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 4:  Preparation of Fragment C7 - 24 by Mickel, Stuart J, Sedelmeier, Gottfried H, Niederer, Daniel, Schuerch, Friedrich, Seger, Manuela, Schreiner, Klaus, Daeffler, Robert, Osmani, Adnan, Bixel, Dominique, Loiseleur, Olivier, Cercus, Jacques, Stettler, Hans, Schaer, Karl, Gamboni, Remo, Bach, Andrew, Chen, Guang-Pei, Chen, Weichun, Geng, Peng, Lee, George T, Loeser, Eric, McKenna, Joseph, Kinder, Frederick R, Konigsberger, Kurt, Prasad, Kapa, Ramsey, Timothy M, Reel, Noela, Repič, Oljan, Rogers, Larry, Shieh, Wen-Chung, Wang, Run-Ming, Waykole, Liladhar, Xue, Song, Florence, Gordon, Paterson, Ian

“…Coupling of C9 - 14 (4) and C15 - 21 (5a) fragments to produce the cis-trisubstituted olefin was achieved using Suzuki-type coupling conditions employed by…”
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The development of a practical synthesis of the potent and selective somatostatin sst 3 receptor antagonist [4-(3,4-difluoro-phenyl)-piperazine-1-yl]-{(4 S,4a S,8a R)-2[( S)-3-(6-methoxy-pyridin-3-yl)-2-methyl-propyl]-decahydroisoquinoline-4-yl}-methanone (NVP-ACQ090) by Bänziger, Markus, Cercus, Jacques, Hirt, Hans, Laumen, Kurt, Malan, Christophe, Spindler, Felix, Struber, Fritz, Troxler, Thomas

“…The decahydroisoquinoline derivative NVP-ACQ090 is a potent and selective antagonist at the somatostatin sst 3 receptor. The original research synthesis of…”
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Practical and Large-Scale Synthesis of r ac-(3S,4aR,10aR)- 6-Methoxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-3-carboxylic Acid Methyl Ester by Bänziger, Markus, Cercus, Jacques, Stampfer, Wolfgang, Sunay, Ustun

“…3- Substituted octahydrobenzo[g]quinolines are important intermediates for pharmaceutically active compounds. A short, efficient synthesis, which is feasible…”
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Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 4:  Preparation of Fragment C 7 - 24 by Mickel, Stuart J., Sedelmeier, Gottfried H., Niederer, Daniel, Schuerch, Friedrich, Seger, Manuela, Schreiner, Klaus, Daeffler, Robert, Osmani, Adnan, Bixel, Dominique, Loiseleur, Olivier, Cercus, Jacques, Stettler, Hans, Schaer, Karl, Gamboni, Remo, Bach, Andrew, Chen, Guang-Pei, Chen, Weichun, Geng, Peng, Lee, George T., Loeser, Eric, McKenna, Joseph, Kinder, Frederick R., Konigsberger, Kurt, Prasad, Kapa, Ramsey, Timothy M., Reel, Noela, Repič, Oljan, Rogers, Larry, Shieh, Wen-Chung, Wang, Run-Ming, Waykole, Liladhar, Xue, Song, Florence, Gordon, Paterson, Ian

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Beispiel für die Evolution der Synthese eines Entwicklungs-produktes: Herstellung des als 5 HT2C/2B-Receptor-Antagonisten wirksamen Indolo-naphthyridin-Derivates SDZ SER-082 in enantiomerenreiner Form by Herbert Mühle, Joachim Nozulak, Jacques Cercus, Ernst Küsters, Ulrich Beutler, Gerhard Penn, Werner Zaugg

“…cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]naphthyridine (rac-4) (SDZ SER-082) is a selective and potent 5-HT2C/2B receptor antagonist,…”
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Beispiel für die Evolution der Synthese eines Entwicklungs-produktes: Herstellung des als 5 HT2C/2B-Receptor-Antagonisten wirksamen Indolo-naphthyridin-Derivates SDZ SER-082 in enantiomerenreiner Form by Herbert Mühle, Joachim Nozulak, Jacques Cercus, Ernst Küsters, Ulrich Beutler, Gerhard Penn, Werner Zaugg

“…cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]naphthyridine (rac-4) (SDZ SER-082) is a selective and potent 5-HT2C/2B receptor antagonist,…”
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