Search Results - "Cerchio, Robert"

Nonhomologous end-joining repair is likely involved in the repair of double-stranded DNA breaks induced by riluzole in melanoma cells by Cerchio, Robert, Marinaro, Christina, Foo, Tzeh Keong, Xia, Bing, Chen, Suzie

“…Our group described the oncogenic potential of a normal neuronal receptor, metabotropic glutamate receptor 1 (GRM1/mGluR1, gene/protein), when aberrantly…”
Get full text

Activation of Grm1 expression by mutated BRaf (V600E) in vitro and in vivo by Chen, Ho-Chung, Sierra, Jairo, Yu, Lumeng Jenny, Cerchio, Jr, Robert, Wall, Brian A, Goydos, James, Chen, Suzie

“…Our laboratory previously showed that ectopic expression of Grm1 is sufficient to induce spontaneous melanoma formation with 100% penetrance in transgenic…”
Get full text

A phase I trial of riluzole and sorafenib in patients with advanced solid tumors: CTEP #8850 by Spencer, Kristen R, Portal, Daniella E, Aisner, Joseph, Stein, Mark N, Malhotra, Jyoti, Shih, Weichung, Chan, Nancy, Silk, Ann W, Ganesan, Shridar, Goodin, Susan, Gounder, Murugesan, Lin, Hongxia, Li, Jiadong, Cerchio, Robert, Marinaro, Christina, Chen, Suzie, Mehnert, Janice M

“…Overexpression of metabotropic glutamate receptor 1 (GRM1) has been implicated in the pathogenesis of multiple cancers. Riluzole, an inhibitor of glutamate…”
Get full text

Riluzole Induces DNA Double Strand Breaks in MGLUR1 Expressing Human Melanoma Cells by Cerchio, Robert M

“…Melanoma is the most aggressive form of skin cancer; in 2018 about 90,000 new cases and 9,000 deaths are expected in the United States. Our group described the…”
Get full text