Search Results - "Cerasa, Laura Serafina"
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Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats
Published in Toxicology (Amsterdam) (07-01-2013)“…Highlights ► Neonatal exposure to permethrin induces cognitive deficits in pre-senescent rats. ► Spatial working memory was tested in a T-maze-rewarded…”
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2
L-Dopa prodrugs: an overview of trends for improving Parkinson's disease treatment
Published in Current pharmaceutical design (01-11-2011)“…L-Dopa is the mainstay of Parkinson's disease therapy; this drug is usually administered orally, but it is extensively metabolized in the gastrointestinal…”
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3
Modulation of monoaminergic transporters by choline-containing phospholipids in rat brain
Published in CNS & neurological disorders drug targets (01-02-2013)“…Choline-containing phospholipids were proposed as cognition enhancing agents, but evidence on their activity is controversial. CDP-choline…”
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4
Carvacrol codrugs: a new approach in the antimicrobial plan
Published in PloS one (10-04-2015)“…The increasing prevalence of antibiotic-resistant bacterial infections led to identify alternative strategies for a novel therapeutic approach. In this study,…”
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5
Characterization of alkanoyl-10- O-minocyclines in micellar dispersions as potential agents for treatment of human neurodegenerative disorders
Published in European journal of pharmaceutical sciences (03-07-2008)“…Minocycline is a widely used antibacterial agent. Moreover, it is also demonstrated to be effective in several neurodegenerative disorders, due to its…”
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6
Codrugs Linking l-Dopa and Sulfur-Containing Antioxidants: New Pharmacological Tools against Parkinson’s Disease
Published in Journal of medicinal chemistry (22-01-2009)“…A series of multifunctional codrugs (1−6) were synthesized to overcome the pro-oxidant effect associated with l-dopa (LD) therapy. Target compounds release LD…”
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7
Antiparkinson prodrugs
Published in Molecules (16-01-2008)“…Parkinson's disease (PD) is a progressive, neurodegenerative disorder which involves the loss of dopaminergic neurons of the substantia nigra pars compacta…”
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Journal Article Book Review -
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Effect of choline-containing phospholipids on brain cholinergic transporters in the rat
Published in Journal of the neurological sciences (15-03-2011)“…Abstract The influence of one week treatment with the choline-containing phospholipids cytidine-5′-diphosphocholine (CDP-choline) and choline alphoscerate…”
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9
New drug delivery strategies for improved Parkinson's disease therapy
Published in Expert opinion on drug delivery (01-04-2009)“…Increasing interest has been addressed toward the introduction of new therapeutic approaches to obtaining continuous dopaminergic stimulation (CDS). The goal…”
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Effect of 17β-estradiol on striatal dopaminergic transmission induced by permethrin in early childhood rats
Published in Chemosphere (Oxford) (01-10-2014)“…•Early life permethrin treated leads to dopaminergic alterations.•Decrease of dopamine was observed in rats co-administered with PERM+17β-estradiol.•Permethrin…”
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11
Development of glycine-α-methyl-proline-containing tripeptides with neuroprotective properties
Published in European journal of medicinal chemistry (27-01-2016)“…Herein is described the synthesis of novel glycine-α-methyl-proline-containing tripeptides (GPMeX tripeptides namely GPMeR, GPMeK, and GPMeH) with the aim of…”
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12
(R)-α-Lipoyl-Glycyl-L-Prolyl-L-Glutamyl Dimethyl Ester Codrug as a Multifunctional Agent with Potential Neuroprotective Activities
Published in ChemMedChem (01-11-2012)“…The (R)‐α‐lipoyl‐glycyl‐L‐prolyl‐L‐glutamyl dimethyl ester codrug (LA‐GPE, 1) was synthesized as a new multifunctional drug candidate with antioxidant and…”
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13
Designing prodrugs for the treatment of Parkinson's disease
Published in Expert opinion on drug discovery (01-05-2012)“…Current Parkinson's disease (PD) therapy is essentially symptomatic, and l-Dopa (LD), is the treatment of choice in more advanced stages of the disease…”
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14
(R)-[alpha]-Lipoyl-Glycyl-L-Prolyl-L-Glutamyl Dimethyl Ester Codrug as a Multifunctional Agent with Potential Neuroprotective Activities
Published in ChemMedChem (01-11-2012)“…The (R)-[alpha]-lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug (LA-GPE, 1) was synthesized as a new multifunctional drug candidate with antioxidant…”
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15
New L-Dopa Codrugs as Potential Antiparkinson Agents
Published in Archiv der Pharmazie (Weinheim) (01-07-2008)“…This paper reports the synthesis and preliminary evaluation of new L‐dopa (LD) conjugates (1 and 2) obtained by joining LD with two different natural…”
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16
Carvacrol Codrugs: A New Approach in the Antimicrobial Plan: e0120937
Published in PloS one (01-04-2015)“…Objective The increasing prevalence of antibiotic-resistant bacterial infections led to identify alternative strategies for a novel therapeutic approach. In…”
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