Search Results - "Centore, Richard C"

Mammalian SWI/SNF Chromatin Remodeling Complexes: Emerging Mechanisms and Therapeutic Strategies by Centore, Richard C., Sandoval, Gabriel J., Soares, Luis Miguel Mendes, Kadoch, Cigall, Chan, Ho Man

“…Small molecule-based targeting of chromatin regulatory factors has emerged as a promising therapeutic strategy in recent years. The development and ongoing…”
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Spartan/C1orf124, a Reader of PCNA Ubiquitylation and a Regulator of UV-Induced DNA Damage Response by Centore, Richard C., Yazinski, Stephanie A., Tse, Alice, Zou, Lee

“…PCNA is a key component of DNA replication and repair machineries. DNA damage-induced PCNA ubiquitylation serves as a molecular mark to orchestrate…”
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TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA by Zou, Lee, Flynn, Rachel Litman, Centore, Richard C, O'Sullivan, Roderick J, Rai, Rekha, Tse, Alice, Songyang, Zhou, Chang, Sandy, Karlseder, Jan

“…Maintenance of telomeres requires both DNA replication and telomere 'capping' by shelterin. These two processes use two single-stranded DNA (ssDNA)-binding…”
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Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma by Conery, Andrew R, Centore, Richard C, Neiss, Adrianne, Keller, Patricia J, Joshi, Shivangi, Spillane, Kerry L, Sandy, Peter, Hatton, Charlie, Pardo, Eneida, Zawadzke, Laura, Bommi-Reddy, Archana, Gascoigne, Karen E, Bryant, Barbara M, Mertz, Jennifer A, Sims, Robert J

“…Pharmacological inhibition of chromatin co-regulatory factors represents a clinically validated strategy to modulate oncogenic signaling through selective…”
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UvrD Limits the Number and Intensities of RecA-Green Fluorescent Protein Structures in Escherichia coli K-12 by CENTORE, Richard C, SANDLER, Steven J

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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XthA (Exonuclease III) regulates loading of RecA onto DNA substrates in log phase Escherichia coli cells by Centore, Richard C, Lestini, Roxane, Sandler, Steven J

“…Exonucleases can modify DNA substrates created during DNA replication, recombination and repair. In Escherichia coli, the effects of several 3'-5' exonucleases…”
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UvrD303, a Hyperhelicase Mutant That Antagonizes RecA-Dependent SOS Expression by a Mechanism That Depends on Its C Terminus by CENTORE, Richard C, LEESON, Michael C, SANDIER, Steven J

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Differential requirements of two recA mutants for constitutive SOS expression in Escherichia coli K-12 by Long, Jarukit Edward, Renzette, Nicholas, Centore, Richard C, Sandler, Steven J

“…Repairing DNA damage begins with its detection and is often followed by elicitation of a cellular response. In E. coli, RecA polymerizes on ssDNA produced…”
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Direct Role for Proliferating Cell Nuclear Antigen in Substrate Recognition by the E3 Ubiquitin Ligase CRL4Cdt2 by Havens, Courtney G., Shobnam, Nadia, Guarino, Estrella, Centore, Richard C., Zou, Lee, Kearsey, Stephen E., Walter, Johannes C.

“…The E3 ubiquitin ligase Cullin-ring ligase 4-Cdt2 (CRL4Cdt2) is emerging as an important cell cycle regulator that targets numerous proteins for destruction in…”
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CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase by Centore, Richard C, Havens, Courtney G, Manning, Amity L, Li, Ju-Mei, Flynn, Rachel Litman, Tse, Alice, Jin, Jianping, Dyson, Nicholas J, Walter, Johannes C, Zou, Lee

“…The proper coordination between DNA replication and mitosis during cell-cycle progression is crucial for genomic stability. During G2 and mitosis, Set8…”
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Preclinical Anticancer Efficacy of BET Bromodomain Inhibitors Is Determined by the Apoptotic Response by Conery, Andrew R, Centore, Richard C, Spillane, Kerry L, Follmer, Nicole E, Bommi-Reddy, Archana, Hatton, Charlie, Bryant, Barbara M, Greninger, Patricia, Amzallag, Arnaud, Benes, Cyril H, Mertz, Jennifer A, Sims, 3rd, Robert J

“…Small-molecule inhibitors of the bromodomain and extraterminal (BET) family of proteins are being tested in clinical trials for a variety of cancers, but…”
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Correction: Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma by Conery, Andrew R, Centore, Richard C, Neiss, Adrianne, Keller, Patricia J, Joshi, Shivangi, Spillane, Kerry L, Sandy, Peter, Hatton, Charlie, Pardo, Eneida, Zawadzke, Laura, Bommi-Reddy, Archana, Gascoigne, Karen E, Bryant, Barbara M, Mertz, Jennifer A, Sims, Robert J

“…Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma. eLife 5:e10483…”
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Abstract B21: Identifying mechanisms of resistance to BET bromodomain inhibition by Centore, Richard C., Hatton, Charlie, Bryant, Barbara, Sims, Robert J.

“…Abstract BET (bromodomain and extra terminal domain) family members are key transcriptional regulators that play an important role driving oncogene expression…”
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Abstract 1224: Discovery of novel BAF inhibitors for the treatment of transcription factor-driven cancers by Centore, Richard C., Soares, Luis M., Vaswani, Rishi G., Ichikawa, Kana, Li, Zhifang, Fan, Hong, Setser, Jeremy, Lahr, David L., Zawadzke, Laura, Chen, Xueying, Barnash, Kimberly D., Muwanguzi, Jordana, Anthony, Neville, Sandoval, Gabriel J., Feldman, Katharine, Adam, Ammar, Huang, David, Schiller, Shawn, Wilson, Kevin, Voigt, Johannes, Hentemann, Martin, Millan, David S., Chan, Ho Man, Bellon, Steven F., Decicco, Carl P., Xu, Lan

“…Abstract The BRG/Brahma-associated factors (BAF) family of chromatin remodeling complexes (also referred to as the mSWI/SNF complex) regulates the chromatin…”
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Abstract 4891: Discovery of novel biomolecular condensate drug targets in oncology using in silico predictive tools by Saar, Kadi L., Rebmann, Marius, Kanchwala, Mohammed, Qamar, Seema, Radhakrishnan, Prathima, Cornish, Jasmine, Doh, Julia, Cattin, Jerome, Rotem, Assaf, Ghandi, Mahmoud, Seeber, Andrew, Centore, Richard C., Teichmann, Sarah A., Knowles, Tuomas, Arora, Shilpi

“…Abstract Biomolecular condensates play a crucial role in maintaining cellular homeostasis by regulating various cellular processes, such as signaling, gene…”
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Abstract 4749: Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma by Keller, Patricia J., Conery, Andrew R., Centore, Richard C., Bommi-Reddy, Archana, Gascoigne, Karen E., Bryant, Barbara M., Mertz, Jennifer A., Sims, Robert J.

“…Abstract Pharmacological inhibition of chromatin co-regulatory factors represents a clinically validated strategy to modulate oncogenic signaling through…”
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Abstract 4749: Bromodomain inhibition of the transcriptional coactivators CBPEP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma by Keller, Patricia J, Conery, Andrew R, Centore, Richard C, Bommi-Reddy, Archana, Gascoigne, Karen E, Bryant, Barbara M, Mertz, Jennifer A, Sims, Robert J

“…Pharmacological inhibition of chromatin co-regulatory factors represents a clinically validated strategy to modulate oncogenic signaling through selective…”
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Abstract 1657: Microfluidics-based screening platform identifies a novel therapeutic approach to targeting EML4-ALK driven cancers by Centore, Richard C., Watson, Matthew, Doh, Julia, Cattin, Jerome, Sgambato, Cinzia, Alex, Amal, Sawant, Janhavi, Radhakrishnan, Prathima, Cornish, Jasmine, Howarth, Alex, Bharatham, Nagakumar, Arter, William E., Qamar, Seema, Saar, Kadi L., Williamson, Douglas, Seeber, Andrew, Groenewegen, Neils, Czekalska, Magdalena, Kartanas, Tadas, Ermann, Niklas, Taher, Ahmed, Knowles, Tuomas, Arora, Shilpi

“…Abstract To achieve proliferative dysregulation, a hallmark of cancer, tumor cells utilize a variety of mechanisms to maintain constitutive oncogenic signaling…”
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Abstract 3231: Pharmacological inhibition of the m6A RNA reader, YTHDC1, as a novel approach to targeting biomolecular condensates in cancer by Centore, Richard C., Charles, Mark, Arora, Mansi, Chen, Yiwen, Watson, Matthew, Kelley, Charlotte, Czekalska, Magdalena, Rebmann, Marius, Ghandi, Mahmoud, Cattin, Jerome, Bharatham, Nagakumar, Radhakrishnan, Prathima, Howarth, Alex, Rudlaff, Gale, Arter, William E., Qamar, Seema, Saar, Kadi, Williamson, Douglas, Seeber, Andrew, Knowles, Tuomas, Arora, Shilpi

“…Abstract Epigenetic dysregulation is a hallmark of cancer, and tumors have evolved complex mechanisms to fine-tune oncogenic gene expression. In acute myeloid…”
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Abstract B19: Targeting dependencies within apoptotic pathways through inhibition of BET bromodomains by Conery, Andrew R., Centore, Richard C., Spillane, Kerry L., Follmer, Nicole E., Bommi-Reddy, Archana, Hatton, Charlie, Bryant, Barbara M., Greninger, Patricia, Amzallag, Arnaud, Benes, Cyril H., Mertz, Jennifer A., Sims, Robert J.

“…Abstract Cancer is driven in large part by dysregulated transcriptional programs that allow for the acquisition of the many ‘Hallmarks of Cancer.' Multiple…”
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