Search Results - "Centonze, Diego"

Special Issue Title: The neuroimmune crosstalk in mood disturbances of neurological and psychiatric diseases by Mandolesi, Georgia, Musella, Alessandra, Centonze, Diego

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Specific dietary interventions to tackle obesity should be a routine part of recommended MS care – Yes by Stampanoni Bassi, Mario, Centonze, Diego

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Beyond rehabilitation in MS: Insights from non-invasive brain stimulation by Leocani, Letizia, Chieffo, Raffaella, Gentile, Antonietta, Centonze, Diego

“…Although the number of disease-modifying treatments for people with multiple sclerosis (pwMS) has meaningfully increased in the past years, targeting repair or…”
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ccf-mtDNA as a Potential Link Between the Brain and Immune System in Neuro-Immunological Disorders by Gambardella, Stefano, Limanaqi, Fiona, Ferese, Rosangela, Biagioni, Francesca, Campopiano, Rosa, Centonze, Diego, Fornai, Francesco

“…Fragments of mitochondrial DNA (mtDNA) are released outside the cell and they appear to persist in extracellular fluids as circulating, cell-free, mtDNA…”
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Synaptopathy connects inflammation and neurodegeneration in multiple sclerosis by Mandolesi, Georgia, Gentile, Antonietta, Musella, Alessandra, Fresegna, Diego, De Vito, Francesca, Bullitta, Silvia, Sepman, Helena, Marfia, Girolama A., Centonze, Diego

“…Key Points Progressive synaptic loss and dysfunction—also known as synaptopathy—occur early in multiple sclerosis (MS), and in experimental autoimmune…”
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Disease-modifying therapies and SARS-CoV-2 vaccination in multiple sclerosis: an expert consensus by Centonze, Diego, Rocca, Maria A., Gasperini, Claudio, Kappos, Ludwig, Hartung, Hans-Peter, Magyari, Melinda, Oreja-Guevara, Celia, Trojano, Maria, Wiendl, Heinz, Filippi, Massimo

“…Coronavirus disease (COVID-19) appeared in December 2019 in the Chinese city of Wuhan and has quickly become a global pandemic. The disease is caused by the…”
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Obesity worsens central inflammation and disability in multiple sclerosis by Stampanoni Bassi, Mario, Iezzi, Ennio, Buttari, Fabio, Gilio, Luana, Simonelli, Ilaria, Carbone, Fortunata, Micillo, Teresa, De Rosa, Veronica, Sica, Francesco, Furlan, Roberto, Finardi, Annamaria, Fantozzi, Roberta, Storto, Marianna, Bellantonio, Paolo, Pirollo, Pamela, Di Lemme, Sonia, Musella, Alessandra, Mandolesi, Georgia, Centonze, Diego, Matarese, Giuseppe

“…Background: Previous studies evidenced a link between metabolic dysregulation, inflammation, and neurodegeneration in multiple sclerosis (MS). Objectives: To…”
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Tumor Necrosis Factor and Interleukin-1β Modulate Synaptic Plasticity during Neuroinflammation by Mandolesi, Georgia, Centonze, Diego, Gentile, Antonietta, Stampanoni Bassi, Mario, Guadalupi, Livia, Vanni, Valentina, Bullitta, Silvia, Fresegna, Diego, De Vito, Francesca, Musella, Alessandra, Rizzo, Francesca Romana, Buttari, Fabio

“…Cytokines are constitutively released in the healthy brain by resident myeloid cells to keep proper synaptic plasticity, either in the form of Hebbian synaptic…”
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Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease by Filomeni, Giuseppe, Graziani, Ilaria, De Zio, Daniela, Dini, Luciana, Centonze, Diego, Rotilio, Giuseppe, Ciriolo, Maria R

“…Abstract This study aims to elucidate the processes underlying neuroprotection of kaempferol in models of rotenone-induced acute toxicity. We demonstrate that…”
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Varicella zoster virus and influenza vaccine antibody titres in patients from MAGNIFY-MS who were treated with cladribine tablets for highly active relapsing multiple sclerosis by Schmierer, Klaus, Wiendl, Heinz, Oreja-Guevara, Celia, Centonze, Diego, Chudecka, Anita, Roy, Sanjeev, Boschert, Ursula

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Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS by Parodi, Benedetta, Rossi, Silvia, Morando, Sara, Cordano, Christian, Bragoni, Alberto, Motta, Caterina, Usai, Cesare, Wipke, Brian T., Scannevin, Robert H., Mancardi, Giovanni L., Centonze, Diego, Kerlero de Rosbo, Nicole, Uccelli, Antonio

“…Dimethyl fumarate (DMF), recently approved as an oral immunomodulatory treatment for relapsing-remitting multiple sclerosis (MS), metabolizes to monomethyl…”
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Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression by Borsellino, Giovanna, Kleinewietfeld, Markus, Di Mitri, Diletta, Sternjak, Alexander, Diamantini, Adamo, Giometto, Raffaella, Höpner, Sabine, Centonze, Diego, Bernardi, Giorgio, Dell'Acqua, Maria Luisa, Rossini, Paolo Maria, Battistini, Luca, Rötzschke, Olaf, Falk, Kirsten

“…In the immune system, extracellular ATP functions as a “natural adjuvant” that exhibits multiple proinflammatory effects. It is released by damaged cells as an…”
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Theoretical and Therapeutic Implications of the Spasticity-Plus Syndrome Model in Multiple Sclerosis by Bruno, Antonio, Dolcetti, Ettore, Centonze, Diego

“…In patients with multiple sclerosis (MS), a typical pattern of muscle tone alteration, known as spasticity, is frequently observed in combination with other…”
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Oral D-Aspartate enhances synaptic plasticity reserve in progressive multiple sclerosis by Nicoletti, Carolina G, Monteleone, Fabrizia, Marfia, Girolama A, Usiello, Alessandro, Buttari, Fabio, Centonze, Diego, Mori, Francesco

“…Background: Synaptic plasticity reserve correlates with clinical recovery after a relapse in relapsing–remitting forms of multiple sclerosis (MS) and is…”
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Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction by Kooij, Gijs, Troletti, Claudio Derada, Leuti, Alessandro, Norris, Paul C, Riley, Ian, Albanese, Maria, Ruggieri, Serena, Libreros, Stephania, van der Pol, Susanne M A, van Het Hof, Bert, Schell, Yoëlle, Guerrera, Gisella, Buttari, Fabio, Mercuri, Nicola Biagio, Centonze, Diego, Gasperini, Claudio, Battistini, Luca, de Vries, Helga E, Serhan, Charles N, Chiurchiù, Valerio

“…Chronic inflammation is a key pathological hallmark of multiple sclerosis (MS) and suggests that resolution of inflammation, orchestrated by specialized…”
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Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential by Procaccini, Claudio, Garavelli, Silvia, Carbone, Fortunata, Di Silvestre, Dario, La Rocca, Claudia, Greco, Dario, Colamatteo, Alessandra, Lepore, Maria Teresa, Russo, Claudia, De Rosa, Giusy, Faicchia, Deriggio, Prattichizzo, Francesco, Grossi, Sarah, Campomenosi, Paola, Buttari, Fabio, Mauri, Pierluigi, Uccelli, Antonio, Salvetti, Marco, Brescia Morra, Vincenzo, Vella, Danila, Galgani, Mario, Mottola, Maria, Zuccarelli, Bruno, Lanzillo, Roberta, Maniscalco, Giorgia Teresa, Centonze, Diego, de Candia, Paola, Matarese, Giuseppe

“…Human CD4+CD25hiFOXP3+ regulatory T (Treg) cells are key players in the control of immunological self-tolerance and homeostasis. Here, we report that signals…”
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Physical exercise and synaptic protection in human and pre-clinical models of multiple sclerosis by Azzolini, Federica, Dolcetti, Ettore, Bruno, Antonio, Rovella, Valentina, Centonze, Diego, Buttari, Fabio

“…In multiple sclerosis, only immunomodulatory and immunosuppressive drugs are recognized as disease-modifying therapies. However, in recent years, several data…”
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The MoxFo initiative—Mechanisms of action: Biomarkers in multiple sclerosis exercise studies by Rosenkranz, Sina C, Ploughman, Michelle, Hvid, Lars G, Zimmer, P., Erickson, K., Stellmann, Jan-Patrick, Centonze, Diego, Friese, Manuel A

“…Background: As exercise exerts neurobiological and immunomodulatory effects, it might also act as a disease-modifying intervention in MS. However, a clear…”
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Homeostasis of serine enantiomers is disrupted in the post-mortem caudate putamen and cerebrospinal fluid of living Parkinson's disease patients by Di Maio, Anna, Nuzzo, Tommaso, Gilio, Luana, Serra, Marcello, Buttari, Fabio, Errico, Francesco, De Rosa, Arianna, Bassi, Mario Stampanoni, Morelli, Micaela, Sasabe, Jumpei, Sulzer, David, Carta, Manolo, Centonze, Diego, Usiello, Alessandro

“…L-serine generated in astrocytes plays a pivotal role in modulating essential neurometabolic processes, while its enantiomer, D-serine, specifically regulates…”
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Emerging Role of Extracellular Vesicles in the Pathophysiology of Multiple Sclerosis by Dolcetti, Ettore, Bruno, Antonio, Guadalupi, Livia, Rizzo, Francesca Romana, Musella, Alessandra, Gentile, Antonietta, De Vito, Francesca, Caioli, Silvia, Bullitta, Silvia, Fresegna, Diego, Vanni, Valentina, Balletta, Sara, Sanna, Krizia, Buttari, Fabio, Stampanoni Bassi, Mario, Centonze, Diego, Mandolesi, Georgia

“…Extracellular vesicles (EVs) represent a new reality for many physiological and pathological functions as an alternative mode of intercellular communication…”
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