Search Results - "Cenni, Vittoria"

The Cutting Edge: The Role of mTOR Signaling in Laminopathies by Chiarini, Francesca, Evangelisti, Camilla, Cenni, Vittoria, Fazio, Antonietta, Paganelli, Francesca, Martelli, Alberto M, Lattanzi, Giovanna

“…The mechanistic target of rapamycin (mTOR) is a ubiquitous serine/threonine kinase that regulates anabolic and catabolic processes, in response to…”
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The Ni(II)-Binding Activity of the Intrinsically Disordered Region of Human NDRG1, a Protein Involved in Cancer Development by Beniamino, Ylenia, Cenni, Vittoria, Piccioli, Mario, Ciurli, Stefano, Zambelli, Barbara

“…Nickel exposure is associated with tumors of the respiratory tract such as lung and nasal cancers, acting through still-uncharacterized mechanisms…”
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Combined Treatment with PI3K Inhibitors BYL-719 and CAL-101 Is a Promising Antiproliferative Strategy in Human Rhabdomyosarcoma Cells by Piazzi, Manuela, Bavelloni, Alberto, Cenni, Vittoria, Salucci, Sara, Bartoletti Stella, Anna, Tomassini, Enrica, Scotlandi, Katia, Blalock, William L, Faenza, Irene

“…Rhabdomyosarcoma (RMS) is a highly malignant and metastatic pediatric cancer arising from skeletal muscle myogenic progenitors. Recent studies have shown an…”
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PCAF Involvement in Lamin A/C-HDAC2 Interplay during the Early Phase of Muscle Differentiation by Santi, Spartaco, Cenni, Vittoria, Capanni, Cristina, Lattanzi, Giovanna, Mattioli, Elisabetta

“…Lamin A/C has been implicated in the epigenetic regulation of muscle gene expression through dynamic interaction with chromatin domains and epigenetic enzymes…”
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Revisiting the Role of GSK3, A Modulator of Innate Immunity, in Idiopathic Inclusion Body Myositis by Piazzi, Manuela, Bavelloni, Alberto, Cenni, Vittoria, Faenza, Irene, Blalock, William L

“…Idiopathic or sporadic inclusion body myositis (IBM) is the leading age-related (onset >50 years of age) autoimmune muscular pathology, resulting in…”
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Emery-Dreifuss Muscular Dystrophy-Associated Mutant Forms of Lamin A Recruit the Stress Responsive Protein Ankrd2 into the Nucleus, Affecting the Cellular Response to Oxidative Stress by Angori, Silvia, Capanni, Cristina, Faulkner, Georgine, Bean, Camilla, Boriani, Giuseppe, Lattanzi, Giovanna, Cenni, Vittoria

“…Background: Ankrd2 is a stress responsive protein mainly expressed in muscle cells. Upon the application of oxidative stress, Ankrd2 translocates into the…”
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Myoblast-Derived Galectin 3 Impairs the Early Phases of Osteogenesis Affecting Notch and Akt Activity by Amore, Emanuela, Cenni, Vittoria, Piazzi, Manuela, Signore, Michele, Orlandi, Giulia, Neri, Simona, Biressi, Stefano, Barone, Rosario, Di Felice, Valentina, Follo, Matilde Y, Bertacchini, Jessika, Palumbo, Carla

“…Galectin-3 (Gal-3) is a pleiotropic lectin produced by most cell types, which regulates multiple cellular processes in various tissues. In bone, depending on…”
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Desmin and Plectin Recruitment to the Nucleus and Nuclei Orientation Are Lost in Emery-Dreifuss Muscular Dystrophy Myoblasts Subjected to Mechanical Stimulation by Cenni, Vittoria, Evangelisti, Camilla, Santi, Spartaco, Sabatelli, Patrizia, Neri, Simona, Cavallo, Marco, Lattanzi, Giovanna, Mattioli, Elisabetta

“…In muscle cells subjected to mechanical stimulation, LINC complex and cytoskeletal proteins are basic to preserve cellular architecture and maintain nuclei…”
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Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin-BAF Interaction and BAF Nuclear Localization by Cenni, Vittoria, Squarzoni, Stefano, Loi, Manuela, Mattioli, Elisabetta, Lattanzi, Giovanna, Capanni, Cristina

“…Reactive Oxygen Species (ROS) are reactive molecules required for the maintenance of physiological functions. Oxidative stress arises when ROS production…”
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Collagen VI Deficiency Impairs Tendon Fibroblasts Mechanoresponse in Ullrich Congenital Muscular Dystrophy by Cenni, Vittoria, Sabatelli, Patrizia, Di Martino, Alberto, Merlini, Luciano, Antoniel, Manuela, Squarzoni, Stefano, Neri, Simona, Santi, Spartaco, Metti, Samuele, Bonaldo, Paolo, Faldini, Cesare

“…The pericellular matrix (PCM) is a specialized extracellular matrix that surrounds cells. Interactions with the PCM enable the cells to sense and respond to…”
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Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H2O2 by Cenni, Vittoria, Bavelloni, Alberto, Beretti, Francesca, Tagliavini, Francesca, Manzoli, Lucia, Lattanzi, Giovanna, Maraldi, Nadir M., Cocco, Lucio, Marmiroli, Sandra

“…A proteomic-based search for novel substrates of Akt was undertaken in C 2 C 12 murine muscle cells. Our data demonstrate that Akt isoform 2 phosphorylates…”
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Tendon Extracellular Matrix Remodeling and Defective Cell Polarization in the Presence of Collagen VI Mutations by Antoniel, Manuela, Traina, Francesco, Merlini, Luciano, Andrenacci, Davide, Tigani, Domenico, Santi, Spartaco, Cenni, Vittoria, Sabatelli, Patrizia, Faldini, Cesare, Squarzoni, Stefano

“…Mutations in collagen VI genes cause two major clinical myopathies, Bethlem myopathy (BM) and Ullrich congenital muscular dystrophy (UCMD), and the rarer…”
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Familial partial lipodystrophy, mandibuloacral dysplasia and restrictive dermopathy feature barrier-to-autointegration factor (BAF) nuclear redistribution by Capanni, Cristina, Squarzoni, Stefano, Cenni, Vittoria, D'Apice, Maria Rosaria, Gambineri, Alessandra, Novelli, Giuseppe, Wehnert, Manfred, Pasquali, Renato, Maraldi, Nadir M., Lattanzi, Giovanna

“…Prelamin A processing impairment is a common feature of a restricted group of rare genetic alterations/disorders associated with a wide range of clinical…”
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Lamin A precursor induces barrier-to-autointegration factor nuclear localization by Capanni, Cristina, Cenni, Vittoria, Haraguchi, Tokuko, Squarzoni, Stefano, Schüchner, Stefan, Ogris, Egon, Novelli, Giuseppe, Maraldi, Nadir, Lattanzi, Giovanna

“…Lamin A, a protein component of the nuclear lamina, is synthesized as a precursor named prelamin A, whose multi-step maturation process involves different…”
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A-type lamins and signaling: The PI 3-kinase/Akt pathway moves forward by Marmiroli, Sandra, Bertacchini, Jessika, Beretti, Francesca, Cenni, Vittoria, Guida, Marianna, De Pol, Anto, Maraldi, Nadir M., Lattanzi, Giovanna

“…Lamin A/C is a nuclear lamina constituent mutated in a number of human inherited disorders collectively referred to as laminopathies. The occurrence and…”
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Lamin A Ser404 Is a Nuclear Target of Akt Phosphorylation in C2C12 Cells by Cenni, Vittoria, Bertacchini, Jessika, Beretti, Francesca, Lattanzi, Giovanna, Bavelloni, Alberto, Riccio, Massimo, Ruzzene, Maria, Marin, Oriano, Arrigoni, Giorgio, Parnaik, Veena, Wehnert, Manfred, Maraldi, Nadir M, de Pol, Anto, Cocco, Lucio, Marmiroli, Sandra

“…Akt/PKB is a central activator of multiple signaling pathways coupled with a large number of stimuli. Although both localization and activity of Akt in the…”
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Prelamin A processing and functional effects in restrictive dermopathy by Columbaro, Marta, Mattioli, Elisabetta, Schena, Elisa, Capanni, Cristina, Cenni, Vittoria, Levy, Nicolas, Navarro, Claire L., Del Coco, Rosalba, Squarzoni, Stefano, Camozzi, Daria, Hutchison, Chris J., Wehnert, Manfred, Lattanzi, Giovanna

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Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria‐related disorders by Evangelisti, Camilla, Cenni, Vittoria, Lattanzi, Giovanna

“…The mammalian target of rapamycin (mTOR) pathway is an highly conserved signal transduction axis involved in many cellular processes, such as cell growth,…”
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Molecular characterization of ANKRD1 in rhabdomyosarcoma cell lines: expression, localization, and proteasomal degradation by Milosevic, Emilija, Novkovic, Mirjana, Cenni, Vittoria, Bavelloni, Alberto, Kojic, Snezana, Jasnic, Jovana

“…Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in children and adolescents. Respecting the age of the patients and the tumor aggressiveness,…”
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Antitumor activity of natural pigment violacein against osteosarcoma and rhabdomyosarcoma cell lines by Milosevic, Emilija, Stanisavljevic, Nemanja, Boskovic, Srdjan, Stamenkovic, Nemanja, Novkovic, Mirjana, Bavelloni, Alberto, Cenni, Vittoria, Kojic, Snezana, Jasnic, Jovana

“…Purpose Sarcomas are rare and heterogenic tumors with unclear etiology. They develop in bone and connective tissue, mainly in pediatric patients. To increase…”
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