Search Results - "Cenni, Bruno"

Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase by Angst, Daniela, Gessier, François, Janser, Philipp, Vulpetti, Anna, Wälchli, Rudolf, Beerli, Christian, Littlewood-Evans, Amanda, Dawson, Janet, Nuesslein-Hildesheim, Barbara, Wieczorek, Grazyna, Gutmann, Sascha, Scheufler, Clemens, Hinniger, Alexandra, Zimmerlin, Alfred, Funhoff, Enrico G, Pulz, Robert, Cenni, Bruno

“…Bruton’s tyrosine kinase (BTK), a cytoplasmic tyrosine kinase, plays a central role in immunity and is considered an attractive target for treating autoimmune…”
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Remibrutinib (LOU064): A selective potent oral BTK inhibitor with promising clinical safety and pharmacodynamics in a randomized phase I trial by Kaul, Martin, End, Peter, Cabanski, Maciej, Schuhler, Carole, Jakab, Annamaria, Kistowska, Magdalena, Kinhikar, Arvind, Maiolica, Alessio, Sinn, Angela, Fuhr, Rainard, Cenni, Bruno

“…Safe and effective new oral therapies for autoimmune, allergic, and inflammatory conditions remain a significant therapeutic need. Here, we investigate the…”
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Remibrutinib (LOU064) inhibits neuroinflammation driven by B cells and myeloid cells in preclinical models of multiple sclerosis by Nuesslein-Hildesheim, Barbara, Ferrero, Enrico, Schmid, Cindy, Huck, Catherine, Smith, Paul, Tisserand, Sarah, Rubert, Joelle, Bornancin, Frederic, Eichlisberger, Denis, Cenni, Bruno

“…Abstract Background Bruton’s tyrosine kinase (BTK) is a key signaling node in B cell receptor (BCR) and Fc receptor (FcR) signaling. BTK inhibitors (BTKi) are…”
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Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling by Holopainen, Tanja, Räsänen, Markus, Anisimov, Andrey, Tuomainen, Tomi, Zheng, Wei, Tvorogov, Denis, Hulmi, Juha J., Andersson, Leif C., Cenni, Bruno, Tavi, Pasi, Mervaala, Eero, Kivelä, Riikka, Alitalo, Kari

“…Cardiac hypertrophy accompanies many forms of heart disease, including ischemic disease, hypertension, heart failure, and valvular disease, and it is a strong…”
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Remibrutinib inhibits hives effector cells stimulated by serum from chronic urticaria patients independently of FcεR1 expression level and omalizumab clinical response by Gimeno, Ramón, Ribas‐Llauradó, Clara, Pesque, David, Andrades, Evelyn, Cenni, Bruno, Ambros, Barbara, Pujol, Ramon, Giménez‐Arnau, Ana M.

“…Background Despite advances in the treatment of chronic urticaria, in a significant percentage of the patients symptoms are not fully controlled with…”
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The Lysosomal Transmembrane Protein 9B Regulates the Activity of Inflammatory Signaling Pathways by Dodeller, Francis, Gottar, Marie, Huesken, Dieter, Iourgenko, Vadim, Cenni, Bruno

“…The intracellular signaling pathway by which tumor necrosis factor (TNF) induces its pleiotropic actions is well characterized and includes unique components…”
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Remibrutinib, a Novel Bruton’s Tyrosine Kinase Inhibitor, Exhibits Improved Target Selectivity and Potency In Vitro (P8-3.003) by Kieseier, Bernd, Cenni, Bruno, Pulz, Robert, Angst, Daniela, Eichlisberger, Denis, Ziehn, Marina

“…Abstract only…”
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Remibrutinib Inhibits Neuroinflammation Driven by B Cells and Myeloid Cells in Preclinical Models of Multiple Sclerosis (P2-3.013) by Kieseier, Bernd, Cenni, Bruno, Nuesslein-Hildesheim, Barbara, Ferrero, Enrico, Huck, Catherine, Eichlisberger, Denis, Ziehn, Marina

“…Abstract only…”
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Meta-analysis for Neurofilament Light Chain as a Biomarker in Mouse Experimental Autoimmune Encephalomyelitis Studies (S17.008) by Kieseier, Bernd, Tisserand, Sarah, Ramseier, Pamela, Uffelmann, Tatjana, Locatelli, Giuseppe, Cenni, Bruno, Nuesslein-Hildesheim, Barbara, Bigaud, Marc

“…Abstract only…”
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BMX and Its Role in Inflammation, Cardiovascular Disease, and Cancer by Cenni, Bruno, Gutmann, Sascha, Gottar-Guillier, Marie

“…Bone marrow kinase on chromosome X (BMX) is a cytosolic tyrosine kinase and a member of the TEC kinase family. BMX is expressed in hematopoietic cells of the…”
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Efficacy and safety of remibrutinib, a selective potent oral BTK inhibitor, in Sjögren's syndrome: results from a randomised, double-blind, placebo-controlled phase 2 trial by Dörner, Thomas, Kaul, Martin, Szántó, Antónia, Tseng, Jui-Cheng, Papas, Athena S, Pylvaenaeinen, Ilona, Hanser, Malika, Abdallah, Nasri, Grioni, Andrea, Santos Da Costa, Aida, Ferrero, Enrico, Gergely, Peter, Hillenbrand, Rainer, Avrameas, Alexandre, Cenni, Bruno, Siegel, Richard M

“…To evaluate the safety and efficacy of remibrutinib in patients with moderate-to-severe Sjögren's syndrome (SjS) in a phase 2 randomised, double-blind trial…”
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Remibrutinib, a Novel Bruton Tyrosine Kinase Inhibitor, Exhibits Improved Target Selectivity and Potency in Vitro by Pulz, Robert, Angst, Daniela, Eichlisberger, Denis, Hayek, Gisele El, Cenni, Bruno

“…Several Bruton's tyrosine kinase inhibitors (BTKis) are in clinical development for multiple sclerosis (MS). In human blood, in vitro binding of covalent…”
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Safety of Remibrutinib Across Immune-mediated Diseases Supports Development in Multiple Sclerosis (P8-6.015) by Kieseier, Bernd, Montalban, Xavier, Williams, Mitzi, Airas, Laura, Saini, Sarbjit, Hide, Michihiro, Sussman, Gordon, Nakahara, Jin, Bermel, Robert, Doerner, Thomas, Loop, Brett, DeLasHeras, Virginia, Willi, Roman, Haemmerle, Sibylle, Zharkov, Artem, Barbier, Nathalie, Azmon, Amin, Siegel, Richard, Cenni, Bruno, Wiendl, Heinz, Maurer, Marcus, Gimenez-Arnau, Ana, Chitnis, Tanuja

“…Abstract only…”
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Estradiol Decreases IGF-1 and IGF-1 Receptor Expression in Rat Aortic Smooth Muscle Cells by Scheidegger, Kathrin J., Cenni, Bruno, Picard, Didier, Delafontaine, Patrick

“…Insulin-like growth factor (IGF-1) is a potent mitogen for vascular smooth muscle cells. Both IGF-1 and its receptor have been shown to be highly expressed in…”
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Remibrutinib: A Novel BTKi in Development for MS With a Favorable Safety Profile in Various Autoimmune Disorders (P7-3.015) by Williams, Mitzi, Airas, Laura, Chitnis, Tanuja, Saini, Sarbjit, Hide, Michihiro, Sussman, Gordon, Nakahara, Jin, Bermel, Robert, Dörner, Thomas, Loop, Brett, Ziehn, Marina, Willi, Roman, Kieseier, Bernd C., Nikolaev, Ivan, Haemmerle, Sibylle, Zharkov, Artem, Siegel, Richard, Cenni, Bruno, Wiendl, Heinz, Maurer, Marcus, Giménez-Arnau, Ana, Montalban, Xavier

“…Abstract only…”
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CARM1 mediates the ligand-independent and tamoxifen-resistant activation of the estrogen receptor alpha by cAMP by Carascossa, Sophie, Dudek, Peter, Cenni, Bruno, Briand, Pierre-André, Picard, Didier

“…The estrogen receptor alpha (ERalpha) is activated as a transcription factor by both estrogen and a large variety of other extracellular signals. The…”
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Design of Potent and Selective Covalent Inhibitors of Bruton’s Tyrosine Kinase Targeting an Inactive Conformation by Pulz, Robert, Angst, Daniela, Dawson, Janet, Gessier, Francois, Gutmann, Sascha, Hersperger, Rene, Hinniger, Alexandra, Janser, Philipp, Koch, Guido, Revesz, Laszlo, Vulpetti, Anna, Waelchli, Rudolf, Zimmerlin, Alfred, Cenni, Bruno

“…Bruton’s tyrosine kinase (BTK) is a member of the TEC kinase family and is selectively expressed in a subset of immune cells. It is a key regulator of antigen…”
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Evaluation of protease‐activated receptor 2 in murine models of arthritis by Busso, Nathalie, Frasnelli, Matthias, Feifel, Roland, Cenni, Bruno, Steinhoff, Martin, Hamilton, Justin, So, Alexander

“…Objective Protease‐activated receptor 2 (PAR‐2) activation has been linked to pro‐ and antiinflammatory cellular responses. We undertook this study to explore…”
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The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase-independent manner by Gottar-Guillier, Marie, Dodeller, Francis, Huesken, Dieter, Iourgenko, Vadim, Mickanin, Craig, Labow, Mark, Gaveriaux, Samuel, Kinzel, Bernd, Mueller, Matthias, Alitalo, Kari, Littlewood-Evans, Amanda, Cenni, Bruno

“…Inflammatory cytokines like TNF play a central role in autoimmune disorders such as rheumatoid arthritis. We identified the tyrosine kinase bone marrow kinase…”
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The in vitro distribution of halofantrine in human blood and Plasmodium falciparum-parasitised red blood cells by Cenni, B, Betschart, B

“…The in vitro distribution of the antimalarial drug halofantrine was measured in drug-preincubated whole blood after separation of the blood cells from the…”
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