Search Results - "Cenci, M A"

Current options and future possibilities for the treatment of dyskinesia and motor fluctuations in Parkinson's disease by Cenci, M A, Ohlin, K E, Odin, P

“…Dyskinesia and motor fluctuations affect up to 90% of patients with Parkinson's disease (PD) within ten years of L-DOPA pharmacotherapy, and represent a major…”
Get more information

Role of striatal l‐DOPA in the production of dyskinesia in 6‐hydroxydopamine lesioned rats by Carta, Manolo, Lindgren, Hanna S., Lundblad, Martin, Stancampiano, Roberto, Fadda, Fabio, Cenci, M. A.

“…We explored possible differences in the peripheral and central pharmacokinetics of l‐DOPA as a basis for individual variation in the liability to dyskinesia…”
Get full text

Pharmacological validation of a mouse model of l-DOPA-induced dyskinesia by Lundblad, M., Usiello, A., Carta, M., Håkansson, K., Fisone, G., Cenci, M.A.

“…Dyskinesia (abnormal involuntary movements) is a common complication of l-DOPA pharmacotherapy in Parkinson's disease, and is thought to depend on abnormal…”
Get full text

Cellular and behavioural effects of the adenosine A2a receptor antagonist KW‐6002 in a rat model of l‐DOPA‐induced dyskinesia by Lundblad, M., Vaudano, E., Cenci, M. A.

“…We have examined the ability of KW‐6002, an adenosine A2a antagonist, to modulate the dyskinetic effects of l‐DOPA in 6‐hydroxydopamine‐lesioned rats. In…”
Get full text

Advances in understanding l -DOPA-induced dyskinesia by Cenci, MA, Lindgren, HS

“…The crucial role of dopamine (DA) in movement control is illustrated by the spectrum of motor disorders caused by either a deficiency or a hyperactivity of…”
Get full text

A model of l-DOPA-induced dyskinesia in 6-hydroxydopamine lesioned mice: relation to motor and cellular parameters of nigrostriatal function by Lundblad, M., Picconi, B., Lindgren, H., Cenci, M.A.

“…l-DOPA-induced dyskinesia is a major complication of l-DOPA pharmacotherapy in Parkinson's disease, and is thought to depend on abnormal cell signaling in the…”
Get full text

Priming for L-DOPA-induced abnormal involuntary movements increases the severity of amphetamine-induced dyskinesia in grafted rats by Lane, E.L., Vercammen, L., Cenci, M.A., Brundin, P.

“…In some patients, graft-induced dyskinesia develops following intrastriatal transplantation of embryonic neural tissue for the treatment of Parkinson's…”
Get full text

Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus: evidence in Parkinson's disease patients by Burguillos, M A, Hajji, N, Englund, E, Persson, A, Cenci, A M, Machado, A, Cano, J, Joseph, B, Venero, J L

“…We show that intranigral lipopolysaccharide (LPS) injection, which provokes specific degeneration of DA neurons, induced caspase-3 activation in the rat…”
Get full text

L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA by Cenci, M. A., Lee, C. S., Björklund, A.

“…Rats sustaining unilateral near‐complete 6‐hydroxydopamine lesions of the mesostriatal dopamine pathway received daily injections of 3,4…”
Get full text

Striatal fosB expression is causally linked with l-DOPA-induced abnormal involuntary movements and the associated upregulation of striatal prodynorphin mRNA in a rat model of Parkinson's disease by Andersson, M, Hilbertson, A, Cenci, M A

“…Rats with unilateral dopamine-denervating lesions sustained a 3-week treatment with a daily l-DOPA dose that is in the therapeutic range for Parkinson's…”
Get full text

A Genetic Mouse Model of Parkinson’s Disease Shows Involuntary Movements and Increased Postsynaptic Sensitivity to Apomorphine by Brehm, N., Bez, F., Carlsson, T., Kern, B., Gispert, S., Auburger, G., Cenci, M. A.

“…Alpha-synuclein (SNCA) protein aggregation plays a causal role in Parkinson’s disease (PD). The SNCA protein modulates neurotransmission via the SNAP receptor…”
Get full text

Platelet Parameters in Healthy and Pathological Pregnancy by Maconi, Mariacaterina, Cardaropoli, Simona, Cenci, A.M.

“…Changes in platelet count (PLT) are very important during pregnancy. Many platelet disorders occur during pregnancy and a reduction in PLT is the most common…”
Get full text

Transcription factors involved in the pathogenesis of L-DOPA-induced dyskinesia in a rat model of Parkinson's disease by Cenci, M A

“…L-DOPA-induced dyskinesia (abnormal involuntary movements) is one of the most debilitating complications of chronic L-DOPA pharmacotherapy in Parkinson's…”
Get full text

L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA by Cenci, M. A., Lee, C. S., Bjorklund, A.

“…Rats sustaining unilateral near-complete 6-hydroxydopamine lesions of the mesostriatal dopamine pathway received daily injections of 3,4…”
Get full text

Changes in the regional and compartmental distribution of FosB- and JunB-like immunoreactivity induced in the dopamine-denervated rat striatum by acute or chronic L-DOPA treatment by Cenci, M.A., Tranberg, A., Andersson, M., Hilbertson, A.

“…This study was carried out in order to examine the effects of acute or chronic L-DOPA treatment on striatally expressed FosB- and JunB-like proteins in a rat…”
Get full text

The impact of graft size on the development of dyskinesia following intrastriatal grafting of embryonic dopamine neurons in the rat by Lane, E.L., Winkler, C., Brundin, P., Cenci, M.A.

“…Intrastriatal transplants of embryonic ventral mesencephalon can cause dyskinesia in patients with Parkinson's disease (PD). We assessed the impact of…”
Get full text

Embryonic ventral mesencephalic grafts improve levodopa-induced dyskinesia in a rat model of Parkinson's disease by Lee, Chong S., Cenci, M. Angela, Schulzer, Michael, Björklund, Anders

“…We investigated the role of dopamine neurons in the manifestation of levodopa-induced dyskinesia in a rat model of Parkinson's disease. Daily treatment with a…”
Get full text

Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease by Lane, E.L, Soulet, D, Vercammen, L, Cenci, M.A, Brundin, P

“…Abstract The observation that neural grafts can induce dyskinesias has severely hindered the development of a transplantation therapy for Parkinson's disease…”
Get full text

Persistent changes in striatal gene expression induced by long-term l-DOPA treatment in a rat model of Parkinson's disease by Westin, J. E., Andersson, M., Lundblad, M., Cenci, M. A.

“…Current knowledge of the molecular changes induced by dopamine denervation and subsequent treatment with l‐DOPA is based on studies performed on relatively…”
Get full text

Evaluation of a new formulation of Bacillus thuringiensis israelensis by Lopes, J, Arantes, O M N, Cenci, M A

“…The aim of this study was to determine the potency (ITU) and efficacy of a liquid formulation of Bacillus thuringiensis israelensis developed by the State…”
Get full text