Search Results - "Cena, V"

Neutral high-generation phosphorus dendrimers inhibit macrophage-mediated inflammatory response in vitro and in vivo by Posadas, I., Romero-Castillo, L., Brahmi, N. El, Manzanares, D., Mignani, S., Majoral, J.-P., Ceña, V.

“…Inflammation is part of the physiological response of the organism to infectious diseases caused by organisms such as bacteria, viruses, fungi, or parasites…”
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Role of generation, architecture, pH and ionic strength on successful siRNA delivery and transfection by hybrid PPV-PAMAM dendrimers by Pavan, G M, Monteagudo, S, Guerra, J, Carrión, B, Ocaña, V, Rodríguez-Lopez, J, Danani, A, Pérez-Martínez, F C, Ceña, V

“…Small interfering RNA (siRNA) constitutes an excellent way of knocking down genes. However, it requires the use of delivery systems to reach the target cells,…”
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Dendrimers as vectors for genetic material delivery to the nervous system by Pérez-Martínez, F C, Ocaña, A V, Pérez-Carrión, M D, Ceña, V

“…Transfection of genetic material into primary neuronal cultures remains a challenge because of the intrinsic difficulty in transfecting this type of cell. This…”
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Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: Involvement of phospholipaseCγ activity and glutamate receptor expression by Giralt, A, Rodrigo, T, Martín, E.D, Gonzalez, J.R, Milà, M, Ceña, V, Dierssen, M, Canals, J.M, Alberch, J

“…Abstract The involvement of brain-derived neurotrophic factor (BDNF) in cognitive processes and the decrease in its expression in Huntington's disease suggest…”
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Acetaminophen potentiates staurosporine‐induced death in a human neuroblastoma cell line by Posadas, I, Vellecco, V, Santos, P, Prieto‐Lloret, J, Ceña, V

“…Background and purpose: Neuroblastoma is the most common solid tumour in infants characterized by a high resistance to apoptosis. Recently, the cyclo‐oxygenase…”
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Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome by Altafaj, X, Ortiz-Abalia, J, Fernández, M, Potier, M.C, Laffaire, J, Andreu, N, Dierssen, M, González-García, C, Ceña, V, Martí, E, Fillat, C

“…Abstract Transgenic mice overexpressing Dyrk1A (TgDyrk1A), a Down syndrome (DS) candidate gene, exhibit motor and cognitive alterations similar to those…”
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Sequential Treatment of SH‐SY5Y Cells with Retinoic Acid and Brain‐Derived Neurotrophic Factor Gives Rise to Fully Differentiated, Neurotrophic Factor‐Dependent, Human Neuron‐Like Cells by Encinas, Mario, Iglesias, Montse, Liu, Yuhui, Wang, Hongyin, Muhaisen, Ashraf, Ceña, Valentin, Gallego, Carme, Comella, Joan X.

“…: A rapid and simple procedure is presented to obtain nearly pure populations of human neuron‐like cells from the SH‐SY5Y neuroblastoma cell line. Sequential…”
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Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria by Mollinedo, F, Fernández, M, Hornillos, V, Delgado, J, Amat-Guerri, F, Acuña, A U, Nieto-Miguel, T, Villa-Pulgarín, J A, González-García, C, Ceña, V, Gajate, C

“…Lipid rafts and mitochondria are promising targets in cancer therapy. The synthetic antitumor alkyl-lysophospholipid analog edelfosine (1- O -octadecyl-2- O…”
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Involvement of mitochondrial potential and calcium buffering capacity in minocycline cytoprotective actions by Fernandez-Gomez, F.J., Galindo, M.F., Gomez-Lazaro, M., González-García, C., Ceña, V., Aguirre, N., Jordán, J.

“…Minocycline, a semisynthetic derivative of tetracycline, displays beneficial activity in neuroprotective in models including, Parkinson disease, spinal cord…”
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Nanoparticle-mediated therapeutic compounds delivery to glioblastoma by Gallego, L, Ceña, V

“…Glioblastoma multiforme is the most common and the most aggressive primary brain tumor, with a median survival of 14 months. This dismal prognostic has turned…”
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Group-I metabotropic glutamate receptors: hypotheses to explain their dual role in neurotoxicity and neuroprotection by Nicoletti, F, Bruno, V, Catania, M.V, Battaglia, G, Copani, A, Barbagallo, G, Ceña, V, Sanchez-Prieto, J, Spano, P.F, Pizzi, M

“…The role of group-I metabotropic glutamate receptors (mGlu1 and 5) in neurodegeneration is still controversial. While antagonists of these receptors are…”
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Role and regulation of p53 in depolarization-induced neuronal death by Jordán, J, Galindo, M.F, González-García, C, Ceña, V

“…The tumor suppressor gene p53 is a potent transcriptional regulator for genes involved in many cellular activities including cell cycle arrest and apoptosis…”
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Adrenal medulla calcium channel population is not conserved in bovine chromaffin cells in culture by Benavides, A., Calvo, S., Tornero, D., González-GarcÍa, C., Ceña, V.

“…During the stress response adrenal medullary chromaffin cells release catecholamines to the bloodstream. Voltage-activated calcium channels present in the cell…”
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Exploring the in vivo toxicity of nanoparticles by Romero-Castillo, L, Posadas, I, Ceña, V

“…Toxicological tests of a xenobiotic play a key role to determine the safety of the new compound before it reaches the market. In this review article, we…”
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Veratridine induces apoptotic death in bovine chromaffin cells through superoxide production by Jordán, Joaquín, Galindo, María F, Calvo, Soledad, González‐García, Carmen, Ceña, Valentín

“…The molecular mechanisms involved in veratridine‐induced chromaffin cell death have been explored. We have found that exposure to veratridine (30 μM, 1 h)…”
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Naloxone inhibits nicotine-induced receptor current and catecholamine secretion in bovine chromaffin cells by Tomé, Angelo R., Izaguirre, Victor, Rosário, Luı́s M., Ceña, Valentı́n, González-Garcı́a, Carmen

“…Nicotine-induced catecholamine (CA) secretion and inward ionic currents were inhibited by the opioid antagonist naloxone in cultured bovine chromaffin cells…”
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The radiologist's role in managing paediatric liver transplantation: personal experience with 40 patients by Sacchetto, P, Veltri, A, Cena, V, Gisolo, F, Gennari, F, Salizzoni, M, Righi, D, Gandini, G

“…The aim of our study was to evaluate the radiologist's role in managing paediatric orthotopic liver transplantation (OLT) through a retrospective review of our…”
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D1 but not D5 Dopamine Receptors Are Critical for LTP, Spatial Learning, and LTP-Induced arc and zif268 Expression in the Hippocampus by Granado, Noelia, Ortiz, Oskar, Suárez, Luz M., Martín, Eduardo D., Ceña, Valentín, Solís, José M., Moratalla, Rosario

“…Recent evidence suggests that glutamatergic and dopaminergic afferents must be activated to induce persistent long-term potentiation (LTP) in the hippocampus…”
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Acetaminophen induces apoptosis in rat cortical neurons by Posadas, Inmaculada, Santos, Pablo, Blanco, Almudena, Muñoz-Fernández, Maríangeles, Ceña, Valentín

“…Acetaminophen (AAP) is widely prescribed for treatment of mild pain and fever in western countries. It is generally considered a safe drug and the most…”
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Extracellular calcium has distinct effects on fast and slow components of the depolarization-induced secretory response from chromaffin cells by Granja, R, Izaguirre, V, Calvo, S, González-García, C, Ceña, V

“…An increase in extracellular Ca2+ concentration from 0.25 to 10 mM enhanced secretion of norepinephrine and epinephrine induced by a high extracellular K+…”
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